A5101965610- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Musculoskeletal pain and rehabilitation
- Myofascial pain diagnosis and treatment
- Vector-borne infectious diseases
- Functional Brain Connectivity Studies
- Insect symbiosis and bacterial influences
- Systemic Lupus Erythematosus Research
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- Coronary Interventions and Diagnostics
- Studies on Chitinases and Chitosanases
- Cleft Lip and Palate Research
- Healthcare Systems and Reforms
- Viral Infections and Outbreaks Research
- Advanced Welding Techniques Analysis
- Glioma Diagnosis and Treatment
- Big Data Technologies and Applications
- Occupational Health and Performance
- Infective Endocarditis Diagnosis and Management
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Gallbladder and Bile Duct Disorders
- Titanium Alloys Microstructure and Properties
- Web Data Mining and Analysis
- Transcranial Magnetic Stimulation Studies
Xuzhou Medical College
2024
The First Affiliated Hospital, Sun Yat-sen University
2021-2024
Sun Yat-sen University
2021-2024
Chinese People's Liberation Army
2020-2024
Beihang University
2024
Institute of Microbiology
2012-2023
Academy of Military Medical Sciences
2023
Beijing Chao-Yang Hospital
2019-2022
Capital Medical University
2019-2022
Second Affiliated Hospital of Dalian Medical University
2010-2021
Heat-lability is a key roadblock that strangles the widespread applications of many biological products. In nature, archaeal and extremophilic organisms utilize amorphous silica as protective biomineral exhibit considerable thermal tolerance. Here we present bioinspired approach to generate thermostable virus by introducing an artificial hydrated exterior on individual virion. Similar thermophiles, silicified viruses can survive longer at high temperature than their wild-type relatives....
Dysbiotic gut microbiota (GM) plays a regulatory role during the pathogenesis of several cardiovascular diseases, including atherosclerosis. GM-derived metabolite phenylacetylglutamine (PAGln) enhances platelet responsiveness and thrombosis potential, thereby inducing major adverse events. However, GM microbial PAGln in in-stent stenosis remains unknown.16S rRNA sequencing was performed on fecal samples 103 coronary artery disease (CAD) patients, 35 individuals with patency (control), 32...
BACKGROUND: Motor control exercise (MCE) effectively alleviates nonspecific chronic low back pain (CLBP), but the neural mechanisms underlying this phenomenon are poorly understood. OBJECTIVE: To study MCE’s in patients with CLBP by resting-state functional magnetic resonance imaging (rs-fMRI). STUDY DESIGN: A prospective, single-blind, randomized, controlled trial. SETTING: Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University. METHODS: 58 were...
Patients with chronic non-specific low back pain (CNSLBP) were found impaired postural control in previous studies. Since the trunk muscle take important efforts on core stability, study aimed to examine relationships of during stance tasks and contractility young adults CNSLBP without. Healthy individuals (n = 25) 30) included. The thickness bilateral transversus abdominis (TrA) lumbar multifidus (MF) was measured rest maximal voluntary contraction, change percentages (TrA%, MF%)...
This study aimed to investigate the effects of progressive postural control exercise (PPCE) vs core stability (CSE) in patients with chronic low back pain (CLBP). A total 34 young-adult participants CLBP were randomly assigned two groups (the PPCE group and CSE group). They received instructions for different training regimens persisting over 8 weeks. Before, after, at 6 months after intervention, evaluated on basis intensity (VAS), degree dysfunction (ODI RMDQ), contractility transversus...
Abstract Objective Chronic low back pain (cLBP) affects nociceptive responses in the cerebellum, which leads to increased perception and sensorimotor control dysfunction. This study aimed investigate altered functional connectivity anterior posterior lobes of cerebellum during cLBP. Design Twenty patients with cLBP 18 healthy participants underwent 3.0 T resting-state magnetic resonance imaging. The bilateral lobule V Crus I were selected as region interest for identifying corresponding...
Chikungunya virus belongs to the genus Alphavirus in family Togaviridae. Here we report complete genome sequence of a chikungunya strain, GD05/2010, isolated 2010 from patient with fever Guangdong, China. The information is important for surveillance this emerging arboviral infection
Background Lumbar paraspinal muscle (LPM) is important in spinal stabilization patients with chronic low back pain (CLBP). However, the electrical properties of LPM CLBP remain unclear. Electrical impedance myography (EIM) a novel and non-invasive technique that provides simple quantitative evaluation LPM. Purpose This study aimed to apply EIM assess between healthy control (HC). Methods Thirty participants (15 participants; 15 controls) were enrolled study. Participants group asked complete...
Genome cyclization is essential for viral RNA (vRNA) replication of the vertebrate-infecting flaviviruses, and yet its regulatory mechanisms are not fully understood. Yellow fever virus (YFV) a notorious pathogenic flavivirus. Here, we demonstrated that group cis-acting elements in YFV balance genome to govern efficient vRNA replication. It was shown downstream 5'-cyclization sequence hairpin (DCS-HP) conserved clade important propagation. By using two different replicon systems, found...
The four serotypes of dengue virus (DENV) represent one the major mosquito-borne pathogens globally; so far no vaccine or specific antiviral is available. During virion maturation, pr protein cleaved from its precursor form prM on surface immature DENV by host protease. Recent findings have demonstrated that not only played critical roles in assembly and but was also involved antibody-dependent enhancement infection. However, B-cell epitopes been well characterized. In this study, a set 11...
In the system of PV grid-connected generation, because dispersion panel, difference sun radiation condition and shadow a part they will cause serious loss energy for parallel panel. order to overcoming raise efficiency system, new maximum power point tracking method called distributed variable step duty ratio perturb is put forward. The MPPT overcomes shortcomings generate electricity quantity descend perturbing speed quickly more suitable this kind generation system. hardware adopts DC/DC...
Japanese encephalitis remains the leading cause of viral in children Asia and is expanding its geographical range to larger areas Australasia. Five genotypes virus (JEV) co-circulate geographically affected areas. In particular, emergence genotype I (GI) JEV has displaced III (GIII) as dominant circulating many Asian regions. However, all approved vaccine products are derived from GIII strains. present study, bioinformatic analysis revealed that GI strains shared two distinct amino acid...
Hyperuricemia-induced cardiac remodeling is at least in part
The yellow fever (YF) live attenuated vaccine strain 17D (termed 17D) has been widely used for the prevention and control of YF disease. However, retains significant neurovirulence viscerotropism in mice, which is probably linked to increased occurrences serious adverse events following vaccination. Thus, development an updated version with improved safety profile high priority. Here, we generated a viable bicistronic virus (YFV) by incorporating internal ribosome entry site (IRES) from...
To evaluate the outcomes following use of folded supraclavicular flap repaired hypopharyngeal combined neck skin defects.
The live attenuated hepatitis A virus vaccine H2 strain was developed by passaging a wild-type H2w isolate in cell cultures. Currently, the mechanism underlying its attenuation phenotype remain largely unknown. In this study, we generated full-length infectious cDNA clone of using in-fusion techniques. recovered (H2ic) from exhibited an efficient replication both hepatoma line Huh7.5.1 and 2BS used for production, similar to parental strain. Additionally, H2ic did not cause disease Ifnar1
To investigate the long-term outcome of patients with acute ST-segment elevation myocardial infarction (STEMI) and a chronic total occlusion (CTO) in non-infarct-related artery (IRA) risk factors for mortality.
Hepatitis A virus (HAV) live-attenuated vaccine H2 strain has been approved for clinical use decades with ideal safety profiles in nonhuman primate models and humans. Recently, type I interferon (IFN) receptor-deficient mice were shown to be susceptible HAV infection. Herein, we sought determine the infection replication dynamics of Ifnar-/- that lack IFN receptor. Following intravenous injection, failed cause obvious symptoms mice, no significant upregulation serum alanine aminotransferase...