A5074557766- Traumatic Brain Injury and Neurovascular Disturbances
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Trauma and Emergency Care Studies
- S100 Proteins and Annexins
- Venous Thromboembolism Diagnosis and Management
- Anesthesia and Neurotoxicity Research
- Gun Ownership and Violence Research
- Acute Ischemic Stroke Management
- Abdominal Trauma and Injuries
- Injury Epidemiology and Prevention
- Pelvic and Acetabular Injuries
- Neonatal and fetal brain pathology
- Radiation Dose and Imaging
- Suicide and Self-Harm Studies
- Atrial Fibrillation Management and Outcomes
- Gastrointestinal Bleeding Diagnosis and Treatment
- Abdominal vascular conditions and treatments
- Organ Donation and Transplantation
- Sepsis Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac Arrest and Resuscitation
- Organ Transplantation Techniques and Outcomes
- Blood transfusion and management
University of Pennsylvania
2015-2024
Temple University
2023-2024
Temple University Hospital
2023-2024
Poudre Valley Hospital
2023
Florida College
2016-2023
Scripps Memorial Hospital
2023
Duke University Hospital
2023
University of Florida
2016-2023
University of Wisconsin–Madison
2023
Yale University
2023
Background: The white blood-cell count and neutrophil differential of the synovial fluid have been reported to high sensitivity specificity in diagnosis periprosthetic infection following total knee arthroplasty. We hypothesized that neutrophils recruited into an infected joint secrete enzymes may be used as markers for infection. In this prospective study, we determined one these enzymes, leukocyte esterase, diagnosing Methods: Between May 2007 April 2010, was obtained preoperatively from...
Synovial fluid white blood cell count is useful for diagnosing periprosthetic infections but the utility of this test in early postoperative period remains unknown as hemarthrosis and inflammation may render standard cutoff values inaccurate.We evaluated diagnostic performance four common laboratory tests, synovial count, differential, C-reactive protein, erythrocyte sedimentation rate to detect infection first 6 weeks after primary TKA.We reviewed 11,964 TKAs identified 146 that had a knee...
One of the most serious complications after major orthopedic surgery is deep wound or periprosthetic joint infection. Various risk factors for infection hip and knee replacement have been reported, including patients' comorbidities surgical technique factors. We investigated whether hyperglycemia diabetes mellitus (DM) are associated with that requires intervention total arthroplasty.We reviewed our computerized database elective primary arthroplasty from 2000 to 2008. Demographic...
The diagnosis of periprosthetic joint infection (PJI) continues to pose a challenge. While many diagnostic criteria have been proposed, gold standard for is lacking. Use multiple within the arthroplasty community raises concerns in patient treatment and comparison research pertaining PJI.We (1) determined variation existing criteria, (2) compared proposed new set that incorporates aspirate cell count analysis, (3) investigated variations between criteria.We retrospectively identified 182...
Background: Recent studies have shown that it is difficult to accurately reduce and assess the reduction of syndesmosis after ankle injury. The most commonly reduced with use clamps compress across tibia fibula. However, intraoperative techniques optimize forceps reductions restore syndesmotic relationships not been systematically studied. purpose present study was evaluate accuracy different rotational vectors clamp placement. Methods: Ten through-the-knee cadaveric specimens were used....
C-reactive protein (CRP) serum assays are a standard element of the diagnostic workup for periprosthetic joint infection (PJI). However, because CRP is marker systemic inflammation, this test not specific to PJI.Our purpose was assess whether synovial fluid and alone could differentiate between infected uninfected revision knee arthroplasties determine which these methods had greatest accuracy.We collected specimens from 66 patients undergoing total arthroplasty. Patients were judged or by...
Optimizing the nature and sequence of diagnostic imaging when managing lower gastrointestinal hemorrhage may reduce subsequent morbidity mortality.To determine if preceding visceral arteriography with computed tomographic angiography (CTA) in acute increases identification localization to CTA was superior nuclear scintigraphy used as a pre-angiogram test.Analysis conducted prospectively acquired data from an interventional radiology database individual electronic medical records academic...
Postoperative infection is a potentially devastating complication after THA and TKA. In the early postoperative period, clinicians often find nonspecific indicators of infection. Although leukocytosis may be sign developing in it also part normal surgical response. QUESTIONS AND PURPOSES: We determined (1) natural history white blood cell values primary TKA, (2) factors associated with leukocytosis, (3) predictive value count for periprosthetic joint infection.Using our institutional...
BACKGROUND Patients with traumatic brain injury (TBI) are at high risk of venous thromboembolism events (VTE). We hypothesized that early chemical VTE prophylaxis initiation (≤24 hours a stable head CT) in severe TBI would reduce without increasing intracranial hemorrhage expansion (ICHE). METHODS A retrospective review adult patients 18 years or older isolated (Abbreviated Injury Scale score, ≥ 3) who were admitted to 24 Level I and II trauma centers from January 1, 2014 December 31 2020...
Tranexamic acid (TXA) given early, but not late, after traumatic brain injury (TBI) appears to improve survival. This may be partly related TXA-driven profibrinolysis and increased leukocyte (LEU)-mediated inflammation when administered late post-injury. We hypothesized that early TXA (1 hour post-TBI), blunts penumbral, blood-brain barrier (BBB) leukocyte-endothelial cell (LEU-EC) interactions microvascular permeability, in vivo compared with administration (24 hours post-TBI).CD1 male mice...
BACKGROUND Traumatic brain injury (TBI) is accompanied by a hyperadrenergic catecholamine state that can cause penumbral neuroinflammation. Prospective human studies demonstrate improved TBI survival with beta blockade (bb), although mechanisms remain unclear. We hypothesized deranged post-TBI blood barrier (BBB) leukocyte mobilization and permeability are bb. METHODS CD1 male mice (n = 64) were randomly assigned to severe TBI—controlled cortical impact: 6 m/s velocity, 1 mm depth, 3...
We observed a substantial increase in the incidence of pulmonary embolism (PE) after total joint arthroplasty (TJA) when multidetector computerized tomography (MDCT) replaced ventilation-perfusion (V/Q) scans as diagnostic modality choice. questioned whether this resulted from detection clinically unimportant PE with more sensitive MDCT and 2007 instituted hypoxia protocol to enhance PE.We determined new increased specificity our workups for suspected important immediate postoperative period...
Fibromyalgia has recently emerged as a diagnosis of exclusion for patients with chronic, widespread pain. We investigated the influence this comorbidity on outcomes total knee arthroplasty (TKA). matched 59 (90 knees) who underwent primary TKA fibromyalgia to control same surgery. Postoperative satisfaction and functional were assessed using Likert scale SF-36 survey, respectively. At 3.4 years' follow-up, less satisfied than patients, had lower preoperative postoperative scores. They...
Brain injury progression after severe traumatic brain (TBI) is associated with worsening cerebral inflammation but it unknown how a concomitant bone fracture (BF) affects this progression. Enoxaparin (ENX) decreases penumbral leukocyte mobilization TBI and improves neurologic recovery. We hypothesized that BF worsens learning/memory recovery weeks ENX recovery.CD1 male mice underwent controlled cortical impact or sham craniotomy without tibial fracture, receiving either daily (0.8 mg/kg)...