A5102019315- Traditional and Medicinal Uses of Annonaceae
- Pancreatic function and diabetes
- Mass Spectrometry Techniques and Applications
- Cancer-related gene regulation
- Glycosylation and Glycoproteins Research
- Natural product bioactivities and synthesis
- Pharmacogenetics and Drug Metabolism
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- RNA modifications and cancer
- Sesquiterpenes and Asteraceae Studies
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
Women's Hospital, School of Medicine, Zhejiang University
2023
Purdue University West Lafayette
2022
University of California, Davis
2020
Guangdong Provincial People's Hospital
2007
More than 75% of ovarian cancer patients are diagnosed at advanced stages and die tumor cell metastasis. This study aimed to identify new epigenetic transcriptomic alterations associated with metastasis.Two sublines low- high-metastasis potentials were derived from the line A2780. Genome-wide DNA methylome transcriptome profiling carried out in these two by Reduced Representation Bisulfite Sequencing RNA-seq technologies. Cell-based assays conducted support clinical findings.There distinct...
Abstract UDP-glucose pyrophosphorylase 2 (UGP2) is a lynchpin metabolic enzyme that rests at the convergence of multiple pathways regulating both glycogen synthesis and glycosylation modifications. Here we elucidated essential role UGP2-mediated in maintenance KRAS-driven cancer using vitro vivo models. A key effector KRAS oncogenic function transcription factor YAP. We identified YAP/TEAD complex as major regulator UGP2 mRNA expression enzymatic activity genomic perturbations, correlative...