A5101678577- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Genomics, phytochemicals, and oxidative stress
- Extraction and Separation Processes
- Fibroblast Growth Factor Research
- Geochemistry and Elemental Analysis
- Nanoplatforms for cancer theranostics
- Curcumin's Biomedical Applications
- Dental Research and COVID-19
- Microencapsulation and Drying Processes
- Immune cells in cancer
- Advanced Drug Delivery Systems
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Protein Hydrolysis and Bioactive Peptides
- Proteins in Food Systems
- Lipid metabolism and biosynthesis
- Phytochemical Studies and Bioactivities
- Toxin Mechanisms and Immunotoxins
Women's Hospital, School of Medicine, Zhejiang University
2019-2025
Yantai University
2025
Jiangsu Normal University
2024
Zhejiang Chinese Medical University
2022-2024
Blood Center of Zhejiang Province
2024
Zhejiang Medicine (China)
2024
Shandong University
2023
Jinshan Hospital of Fudan University
2023
Zhejiang University
2021
Yangtze University
2020
Abstract Background Emerging evidence has shown that circular RNAs (circRNAs) play essential roles in cancer biology and are potential biomarkers targets for therapy. However, the expression function of circRNAs ovarian carcinogenesis its progression remain elusive. Methods RNA sequencing was performed to reveal circRNA profiles cancerous normal tissues. Single-molecule in-situ hybridization used quantify circPLEKHM3 tumor Cell-based in-vitro in-vivo assays were subsequently conducted...
β-Elemene (IUPAC name: (1 S,2 S,4 R)-1-ethenyl-1-methyl-2,4-bis(prop-1-en-2-yl) cyclohexane), is a natural compound found in turmeric root. Studies have demonstrated its diverse biological functions, including anti-tumor properties, which been extensively investigated. However, these not yet reviewed. The aim of this review was to provide comprehensive summary β-elemene research, with respect disease treatment.
Abstract Background CircRNAs are a novel class of evolutionarily conserved noncoding RNA molecules that form covalently closed continuous loop structures without 5′ caps and 3′ poly(A) tails. Accumulating evidence suggests circRNAs play important regulatory roles in cancer promising biomarkers for diagnosis prognosis, as well targets therapy. In this study, we identify explore the role circRNA, circFBXO7, ovarian cancer. Methods rRNA-depleted RNA-sequencing was performed to differentially...
The effective enrichment and recovery of rare earth elements (REEs) from wastewater holds significant practical value for both the sustainable utilization REEs restoration ecological environments. In this study, magnetic zeolite was successfully synthesized by using tailings (RET) as raw material, with addition Fe3O4 to introduce a phase. Th exhibits high crystallinity, excellent thermal stability, substantial specific surface area 483.8 m2/g, rapid adsorption kinetics. maximum capacities...
Abstract Circular RNAs (circRNAs) are a distinctive class of non‐coding with covalent closed‐loop structure, lacking 5′ caps and 3′ poly(A) tails. These molecules prevalent in eukaryotes play key roles cancer. Here, the function new circRNA, circMETTL6, ovarian cancer is identified investigated. The prognostic significance circMETTL6 assessed using RNA situ hybridization. Functional studies involving overexpression performed both vitro vivo. Mechanistic investigations RNA‐seq, pull‐down,...
Abstract Long non-coding RNAs (lncRNAs) play key roles in cancer development and progression. However, the biological function clinical significance of most lncRNAs cervical remain elusive. In this study, we explore mechanism lncRNA surfactant associated 1 (SFTA1P) cancer. We firstly identified SFTA1P by analyzing RNA sequencing data from our previous study The Cancer Genome Atlas (TCGA). then verified expression qRT-PCR. cell proliferation migration capacity was assessed using CCK-8, colony...
Glutamine is critical for tumor progression, and restriction of its availability emerging as a potential therapeutic strategy. The metabolic plasticity cells helps them adapting to glutamine restriction. However, the role cholesterol metabolism in this process relatively unexplored. Here, we reported that deprivation inhibited synthesis hepatocellular carcinoma (HCC). Reactivation enhanced glutamine-deprivation-induced cell death HCC cells, which partially duo augmented NADPH depletion lipid...
Objective: To demonstrate the effectiveness of Huangqin decoction (Huangqin Tang in Chinese, HQT) combined with Radix Actinidiae chinensis (Tengligen TLG) under guidance “dampness–heat theory” preventing and treating colorectal cancer (CRC) dampness–heat accumulation to preliminarily reveal its mechanism. Methods : The mice model CRC was established by intraperitoneal injection AOM consumption 2.5% DSS solution, celecoxib, HQT, TLG, their combination (HQT + were administered at same time....
Abstract In this study, the encapsulation of goose blood hydrolysate (GBH) was performed within nanoliposomes. We investigated physicochemical properties, stability, antioxidant indices, morphology nanoparticles, digestion stability in simulated gastrointestinal fluid, differential scanning calorimetry (DSC) analysis, and Fourier transform infrared (FTIR) spectroscopy. GBH successfully encapsulated into nanoliposomes using reverse‐phase evaporation method. The entrapment efficiency...
To evaluate the effectiveness of a prevention strategy against spread SARS-CoV-2 infection among dental hospital staff over 3-month period.The strategy, which adopted healthcare protective measures, including patient triage and correct usage personal preventive equipment, was evaluated by detection serological testing. Patients who visited Affiliated Stomatology Hospital, Zhejiang University School Medicine, Hangzhou, China, between January 31 March 1 (lockdown period) 2 April 27 (reopening...
More than 75% of ovarian cancer patients are diagnosed at advanced stages and die tumor cell metastasis. This study aimed to identify new epigenetic transcriptomic alterations associated with metastasis.Two sublines low- high-metastasis potentials were derived from the line A2780. Genome-wide DNA methylome transcriptome profiling carried out in these two by Reduced Representation Bisulfite Sequencing RNA-seq technologies. Cell-based assays conducted support clinical findings.There distinct...
Hypoxia is a characteristic feature of malignancy; however, its effect on metabolism remains unclear. In this study, Hepa1-6 cells were cultured under hypoxic conditions and their metabolites analyzed. Elevated levels L-serine along with increased glycolytic activity are prominent features hypoxia. Transcriptome sequencing revealed the downregulation genes involved in synthesis metabolism, which was confirmed by PCR analysis comparison public databases. Further experimental evidence...
BACKGROUND: The role of ELAPOR1 has been evaluated in several cancers but not elucidated colorectal cancer (CRC). OBJECTIVE: To investigate the CRC. METHODS: In present study, correlation between and survival CRC patients TCGA-COAD-READ datasets was predicted, difference expression tumor normal tissues analyzed. measured by immunohistochemistry. Then, ELAPOR1-shRNA plasmids were constructed transfected into SW620 RKO cells. effects assessed CCK-8, colony formation, transwell, wound healing...