Poststroke cognitive impairment (PSCI) is prevalent in stroke patients. The etiology of PSCI remains largely unknown. We previously found that induces gut microbiota dysbiosis which affects brain injury. Hereby, we aimed to investigate whether the contributes pathogenesis PSCI.83 patients were recruited and their function measured by Montreal Cognitive Assessment (MoCA) scores 3 months after onset. peripheral inflammatory factor levels compositions analyzed. Fecal transplantation from mice...

Post-stroke cognitive impairment (PSCI) is a common complication after stroke, but effective therapy limited. Identifying potential risk factors for intervention warranted. We investigated whether serum superoxide dismutase (SOD) levels were related to mild acute ischemic stroke (AIS) by using prospective cohort design.A total of 187 patients diagnosed with AIS (National Institutes Health Stroke Scale ≤ 8) recruited. Serum SOD, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP),...

Background and Purpose Identifying risks of stroke-associated pneumonia (SAP) is important for clinical management. We aimed to evaluate the association between gut microbiome composition SAP in patients with acute ischemic stroke (AIS). Methods A prospective observational study was conducted, 188 AIS were enrolled as training cohort. Fecal serum samples collected at admission. diagnosed by specialized physicians, disease severity scores recorded. subjected 16S rRNA V4 tag sequencing...

Studies have shown that the intestinal microbiome of stroke patients is significantly altered and degree microbiota disturbance correlates with prognosis. Enteral nutrition (EN) can reshape important for dysphagia. We aimed to describe in ischemic cerebral infarction receiving standard EN.First, 17 healthy controls (HCs), 54 oral feeding (ON), 50 EN were matched investigate changes first week after admission dynamic group second week. Second, we investigated relationship between clinical...

The interaction between light's spin and orbital angular momentum under nonparaxial conditions not only facilitates many fundamental sciences but also underpins a variety of applications. Such strong coupling the two separable dimensions normally occurs when light propagates through nanoscale inhomogeneous media or tight focusing. In this regard, subwavelength scrutinizing spatial distribution such attributes is utmost importance. Here, we demonstrate nanointerferometric scheme to map with...

The recent advances in wireless communication technology enable high-speed vehicles to download data from roadside units (RSUs). However, the volume of individual vehicle is rather restricted due high mobility and limited transmission range vehicles, bringing users poor performance. To address this issue, we exploit combination both clustering carry-and-forward schemes paper. Our scheme coordinates cooperation multiple infrastructures, cluster formation same direction forwarding reverse...

Here, we demonstrate a flat nanofocalizer for converging light field into uniform subwavelength spot array based on the fractional Talbot effect by developing direct laser writing technique with 3D fabrication precision. The endows device merits of high compression ratio and modular design capability transforming plane wave arrayed focal spots. By combining synergistic printing technique, introduce buffer layer improving precision structural height in favor accurately manipulating phase...

We propose and numerically investigate a novel ultra-high quality (Q) factor metallic micro-cavity based on concentric double metal-insulator-metal (MIM) rings (CDMR). In this CDMR cavity, because of the angular momentum matching, strong coupling occurs between same order modes inner outer with huge resonance frequency difference. Consequently, energy distribution in presents enormous Especially, for quasi-in-phase modes, is confined ring mainly, which suppresses radiation loss greatly...

Screened bonding (SB), screened antibonding (SA) and charge transfer plasmon (CTP) modes in the conductively connected nanorod heterodimer are studied detail by simulation. All of SB, SA CTP can be observed extinction spectra heterodimer. Also, amplitudes three tuned changing radius cylinder conductive connection. Even amplitude mode to higher than that SB mode, which is difficult achieve an unconnected Furthermore, wavelengths adjusted with a high degree freedom, since wavelength mainly...

Plasmonic structural colors have plenty of advantages over traditional based on colorants. The pulsed laser provides an important method generating plasmonic with high efficiency and low cost. Here, we present color printing Al nanodisc structures through curvature-driven shape transition. We systematically study the mechanism morphologic evolution below thermal melting threshold. A multi-pulse-induced accumulated photothermal effect subsequent surface atom diffusion model are adopted to...

Hypoxia is a characteristic feature of malignancy; however, its effect on metabolism remains unclear. In this study, Hepa1-6 cells were cultured under hypoxic conditions and their metabolites analyzed. Elevated levels L-serine along with increased glycolytic activity are prominent features hypoxia. Transcriptome sequencing revealed the downregulation genes involved in synthesis metabolism, which was confirmed by PCR analysis comparison public databases. Further experimental evidence...

The characteristics of neutrophils play a crucial role in defining the tumor inflammatory environment. However, function tumor-associated (TANs) immunity and their response to immune checkpoint inhibitors (ICIs) remains incompletely understood. By analyzing single-cell RNA sequencing data from over 600,000 cells gastric cancer (GSE163558 GSE183904), colorectal (GSE205506), lung (GSE207422), we identified neutrophil subsets primary that are associated with treatment ICIs. Specifically,...

In order to realize unidirectional optical transmission (UOT), a single-layer metallic grating (SMG) consisting of cambered resonators (CRs) is proposed. Numerical simulation results show that the transmittance contrast ratio SMG can reach about 5000 with high 39%. UOT from diffraction enhancement or suppression in direction. Diffraction manipulated by interference electromagnetic radiation local surface plasmons on CRs. Our structure has sub-100 nm thickness and be used ultracompact devices...

Multi-focusing of light is a crucial capability for photonic devices that can be effectively achieved by precisely modulating the phase delay on incident wavefront. However, integrating functional structures into optical fibers remote focusing remains challenging due to complex device design and limited fabrication approaches. Here, we present metalens array end-face tailored single-mode step-index fiber field closely packed focal spot array. The metalenses are configured based fractional...

In conductively connected nanoparticles, the bonding dimer plasmons (BDP) mode and charge transfer plasmon (CTP) are allowed at different wavelengths. We present a nanocuboidal shaped system with huge coupling surface areas. The red shift of extinction spectra occurs for increasing gap decreasing conductive junction cross sectional area. With change electric field distribution brought by connection, we also get CTP over 250 nm moving connection outward less than 50 nanometers horizontally....

Orbital angular momentum (OAM) beam with helical phase distribution has demonstrated important applications in information optics, optical trapping, and manipulation. In this paper, we designed a planar device which can generate periodic array of focused orbital beams. Based on detour encoding, the calculated by fractional Talbot effect is implemented device. The property square hexagonal structures simulated finite difference time domain (FDTD) respectively. explicit advantages being easy...