A5089260049- RNA modifications and cancer
- Cancer-related gene regulation
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- HVDC Systems and Fault Protection
- RNA and protein synthesis mechanisms
- Genomics and Chromatin Dynamics
- Pluripotent Stem Cells Research
- Epigenetics and DNA Methylation
Umeå University
2018-2024
National Institutes of Health
2024
National Cancer Institute
2024
Institut de Biologie Paris-Seine
2019-2020
Transgene (France)
2019-2020
Laboratoire de Biologie du Développement
2019-2020
Sorbonne Université
2019-2020
Epigénétique et Destin Cellulaire
2017
Sorbonne Paris Cité
2017
Université Paris Cité
2017
Abstract Cancer stem cells (CSCs) are a small but critical cell population for cancer biology since they display inherent resistance to standard therapies and give rise metastases. Despite accruing evidence establishing link between deregulation of epitranscriptome-related players tumorigenic process, the role messenger RNA (mRNA) modifications in regulation CSC properties remains poorly understood. Here, we show that cytoplasmic pool fat mass obesity-associated protein (FTO) impedes...
Abstract Alternative splicing (AS) enables differential inclusion of exons from a given transcript, thereby contributing to the transcriptome and proteome diversity. Aberrant AS patterns play major roles in development different pathologies, including breast cancer. N 6 -methyladenosine (m A), most abundant internal modification eukaryotic mRNA, influences tumor progression metastasis cancer, it has been recently linked regulation. Here, we identify specific signature associated with...
Abstract 2′-O-Methylation (Nm) represents one of the most common RNA modifications. Nm affects structure and function with crucial roles in various RNA-mediated processes ranging from silencing, translation, self versus non-self recognition to viral defense mechanisms. Here, we identify two methyltransferases (Nm-MTases) Drosophila melanogaster (CG7009 CG5220) as functional orthologs yeast TRM7 human FTSJ1. Genetic knockout studies together MALDI-TOF mass spectrometry RiboMethSeq mapping...
Abstract Lysine-specific histone demethylase 1 (LSD1) is a that plays critical role in epigenetic regulation by removing the methyl group from mono- and di-methylated lysine 4 on H3 (H3K4me1/2), acting as repressor of gene expression. Recently, catalytically independent functions LSD1, serving scaffold for assembling chromatin-regulator transcription factor complexes, have been identified. Herein, we show first time LSD1 interacts with chromodomain-helicase-DNA-binding protein 7 (CHD7) mouse...
Abstract 2’-O-methylation (Nm) represents one of the most common RNA modifications. Nm affects structure and function with crucial roles in various RNA-mediated processes ranging from silencing, translation, self versus non-self recognition to viral defense mechanisms. Here, we identify two novel methyltransferases (Nm-MTases) Drosophila melanogaster (CG7009 CG5220) as functional orthologs yeast TRM7 human FTSJ1, respectively. Genetic knockout studies together MALDI-TOF mass spectrometry...
ABSTRACT Alternative splicing (AS) enables differential inclusion of exons from a given transcript, thereby contributing to the transcriptome and proteome diversity. Aberrant AS patterns play major roles in development different pathologies, including breast cancer. N 6 -methyladenosine (m A), most abundant internal modification eukaryotic mRNA, influences tumor progression metastasis cancer, it has been recently linked regulation. Here, we identify specific signature associated with...