A5056581606- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Pregnancy and Medication Impact
- Neonatal and fetal brain pathology
- Delphi Technique in Research
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Eosinophilic Esophagitis
- Preterm Birth and Chorioamnionitis
- Neuroscience of respiration and sleep
- Birth, Development, and Health
The University of Adelaide
2024-2025
University of South Australia
2022-2025
Abstract The mechanisms linking maternal asthma (MA) exposure in utero and subsequent risk of childhood are not fully understood. Pathological airway remodelling, including reticular basement membrane thickening, has been reported infants children who go on to develop later childhood. This suggests altered development before birth as a mechanism underlying increased exposed MA. We hypothesised that MA would reduce diameter increase airway‐associated smooth muscle area thickness neonatal...
Abstract Asthma is the most common respiratory condition during pregnancy and increases risks of adverse perinatal outcomes. symptoms change in ∼60% pregnancies, but whether this due to itself unclear. We tested hypothesis that physiological changes worsen asthma severity an ovine experimental model allergic asthma. Three‐year‐old Merino ewes were randomly allocated either control or groups. was induced through sensitisation repeated airway challenge with house dust mite allergen. compared...
Maternal asthma is associated with increased rates of neonatal lung disease, and fetuses from asthmatic ewes have fewer surfactant-producing cells lower surfactant-protein B gene (SFTPB) expression than controls. Antenatal betamethasone increases surfactant production in preterm babies, we therefore tested this therapy experimental maternal asthma. Ewes were sensitised to house dust mite allergen, an phenotype induced by fortnightly allergen challenges; controls received saline. Pregnant...
Introduction The fetal haemodynamic response to acute episodes of hypoxaemia are well characterised. However, how these responses change when the becomes more chronic in nature such as that associated with growth restriction (FGR), is less understood. Herein, we utilised a combination clinically relevant MRI techniques comprehensively characterize and differentiate occurring during periods hypoxaemia. Methods Prior conception, carunclectomy surgery was performed on non-pregnant ewes induce...