A5072538572- Health Systems, Economic Evaluations, Quality of Life
- Neonatal Respiratory Health Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Bariatric Surgery and Outcomes
- Asthma and respiratory diseases
- Biosimilars and Bioanalytical Methods
- Diet and metabolism studies
- Dementia and Cognitive Impairment Research
- Pain Management and Opioid Use
- Statistical Methods in Clinical Trials
- Blood Pressure and Hypertension Studies
- Head and Neck Cancer Studies
- Palliative Care and End-of-Life Issues
- Hemodynamic Monitoring and Therapy
- Pregnancy and Medication Impact
- Diabetes Treatment and Management
- Heart Failure Treatment and Management
- Coronary Interventions and Diagnostics
- Antibiotics Pharmacokinetics and Efficacy
- Vascular Procedures and Complications
- Oral health in cancer treatment
- Heart rate and cardiovascular health
- Obesity and Health Practices
- Central Venous Catheters and Hemodialysis
- Neuroscience of respiration and sleep
Australian Regenerative Medicine Institute
2013-2025
Monash University
1994-2025
Trinity College Dublin
2024-2025
Federation University
2023
Aintree University Hospital
2020-2021
University of Liverpool
1999-2021
Peninsula College of Medicine and Dentistry
2021
University of Plymouth
2021
NextSense
2021
University of Glasgow
2018-2020
To identify the source (press releases or news) of distortions, exaggerations, changes to main conclusions drawn from research that could potentially influence a reader's health related behaviour.Retrospective quantitative content analysis.Journal articles, press releases, and news, with accompanying simulations.Press (n = 462) on biomedical science issued by 20 leading UK universities in 2011, alongside their associated peer reviewed papers news stories 668).Advice readers change behaviour,...
Scand J Caring Sci; 2012; 26; 12–19 A community‐based exercise programme to improve functional ability in people with Alzheimer’s disease: a randomized controlled trial Rationale: Dementia is common neurodegenerative condition older age associated decline across multiple domains. This impacts not only on the person dementia, but also their informal carers and health aged care systems. With number of dementia rapidly increasing few effective treatments, there now critical need for...
Thirty-one patients with acute cerebral infarction were treated the thrombolytic agent urokinase for either a single or double infusion period, each of ten hours. The effects therapy administered at dosage rates 1,200, 1,500 1,700 CTA units per pound body weight hour followed by serial blood coagulation and other biochemical studies. In used, produced prompt sustained increase, 20-fold to 40-fold, plasma activity relatively minor disturbance system. Nevertheless, hemorrhagic complications...
Background Chronic myeloid leukemia is characterized by a reciprocal translocation between chromosomes 9 and 22, creating the fusion gene BCR-ABL. The clinical significance of type BCR-ABL transcript in newly diagnosed patients chronic phase treated with imatinib 400 mg from initial diagnosis remains unknown.Design Methods We analyzed outcome 78 patients, aged 16 or over, mg. Of these, 71 expressed either e13a2 e14a2 transcripts. transcripts were assayed quantitative real-time polymerase...
Purpose : To determine the benefits for patients who received an electric powered inoor/outdoor chair (EPIOC) and to quantify their perceived changes quality of life. Method Community-based cohort study all provided with EPIOC over 4 months; followed up about 3 months later in a community served by regional wheelchair service North West London (population 3.1 million) using EuroQol EQ-5D visual analogue scales each five dimensions EQ-5D. Results Sixty-four users were assessed initially 51...
<h3>Objective</h3> Ivabradine, a specific heart rate lowering therapy, has been shown in randomised placebo-controlled study, Systolic HF Treatment with the I<sub>f</sub> Inhibitor Ivabradine Trial (SHI<sub>f</sub>T), to significantly reduce composite end point of cardiovascular death and hospitalisation for worsening failure (HF) patients systolic who are sinus rhythm ≥70 bpm, when added optimised medical therapy (HR: 0.82, 95% CI 0.75 0.90, p<0.0001). We assessed cost effectiveness...
Plasma fibrinogen chromatography is a method for quantification of high molecular weight complexes (HMWFC), native and other derivatives in plasma. Enchanced formation fibrin, intravascular coagulation, thrombus formation, etc., are reflected by elevation plasma HMWFC, the distinguishes between subjects with normal pathological rates fibrin formation. Serial standard blood coagulation assays, including chromatography, neurological studies were performed on 220 patients admitted to stroke...
Abstract Aims/hypothesis Approximately 10% of total healthcare budgets worldwide are spent on treating diabetes and its complications, increasing globally because ageing populations more expensive second-line medications. The aims the study were to estimate within-trial lifetime cost-effectiveness weight management programme, which achieved 46% remissions type 2 at year 1 36% in Diabetes Remission Clinical Trial (DiRECT). Methods Within-trial analysis assessed costs Counterweight-Plus...
Abstract Asthma is the most common respiratory condition during pregnancy and increases risks of adverse perinatal outcomes. symptoms change in ∼60% pregnancies, but whether this due to itself unclear. We tested hypothesis that physiological changes worsen asthma severity an ovine experimental model allergic asthma. Three‐year‐old Merino ewes were randomly allocated either control or groups. was induced through sensitisation repeated airway challenge with house dust mite allergen. compared...
Young women formed only a small minority of those convicted gang-related crimes violence in the Manchester conurbation last three decades nineteenth century. Nonetheless, press reports and court records document both their occasional participation confrontations between rival gangs more frequent involvement collective assaults upon local people police. Female gang members were loudly condemned as 'vixens', 'viragoes' 'Amazons' press, subjected to stern lectures by magistrates who deplored...
Maternal asthma is associated with increased rates of neonatal lung disease, and fetuses from asthmatic ewes have fewer surfactant-producing cells lower surfactant-protein B gene (SFTPB) expression than controls. Antenatal betamethasone increases surfactant production in preterm babies, we therefore tested this therapy experimental maternal asthma. Ewes were sensitised to house dust mite allergen, an phenotype induced by fortnightly allergen challenges; controls received saline. Pregnant...
Objective To estimate the comparative lifetime cost-effectiveness of sequenced therapy with tumor necrosis factor (TNF) antagonists as initial therapeutic intervention for patients early rheumatoid arthritis (RA). Methods Because RA switch regimens many times throughout course disease, interventions were modeled, continuing until last effective agent failed or death occurred. The model used published clinical outcomes from short-term, randomized controlled trials. Direct treatment costs and...
The aim of this article is to discuss methods used analyze health-related quality life (HRQoL) data from randomized controlled trials (RCTs) for decision analytic models. analysis presented in paper was provide HRQoL the ivabradine health technology assessment (HTA) submission chronic heart failure. We have a large, longitudinal EuroQol five-dimension questionnaire (EQ-5D) dataset Systolic Heart Failure Treatment with I f Inhibitor Ivabradine Trial (SHIFT) (clinicaltrials.gov: NCT02441218)...
Fibroblast growth factors (FGFs) are a family of heparin binding proteins involved in many biological processes. These act through tyrosine kinase receptors (FGFRs); we have previously used immunohistochemistry to study FGFRs-1-4 foetal, immature and adult rat testes, found discrete cell- stage-specific localisation. Alternative mRNA splicing FGFRs-1-3 leads functional variants (IIIb IIIc) with distinct ligand affinities, therefore identified the specific expression FGFR localisation FGF...
Abstract Aim The Counterweight‐Plus weight management programme achieved 46% remission of Type 2 diabetes at 1 year in the Di RECT trial. We estimated implementation costs and its 1‐year cost‐effectiveness terms remission, compared with usual care, from UK National Health Service ( NHS ) perspective. Methods Within‐trial total included set‐up running (practitioner appointment visits, low‐energy formula diet sachets training), oral anti‐diabetes anti‐hypertensive medications, healthcare...
Key points We studied the effects of preconceptional allergen sensitisation and repeated airway challenges during pregnancy on maternal immune functions pregnancy, maternal, fetal placental phenotype in late sheep. This protocol induced responses consistent with an allergic asthmatic phenotype. During lung resistance eosinophil influx by increased progressively sheep, smooth muscle content was greater than control ewes. Effects growth development were those asthma humans. Maternal decreased...
Objective: To evaluate the cost-effectiveness of atypical antipsychotic treatment sequences for management stable schizophrenia in UK.Research design and methods: A Markov model was developed to assess cost per quality-adjusted life year (QALY) gained from 12 alternative each containing two four antipsychotics (aripiprazole, olanzapine, quetiapine risperidone), followed by clozapine. The main parameters were populated with data Clinical Antipsychotic Trials Intervention Effectiveness (CATIE)...
To evaluate the long-term cost-effectiveness of 12-months treatment with prasugrel vs clopidogrel from four European healthcare systems' perspectives (Germany, Sweden, Netherlands, and Turkey).In TRITON-TIMI 38 trial, patients an acute coronary syndrome (ACS) undergoing percutaneous intervention (PCI) were treated or clopidogrel. Prasugrel reduced composite end-point (cardiovascular death, MI, stroke), but increased TIMI major bleeding. A Markov model was constructed to facilitate a lifetime...