A5027382850- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Lysosomal Storage Disorders Research
- Metabolism and Genetic Disorders
- Glycogen Storage Diseases and Myoclonus
- Biochemical and Molecular Research
- Vitamin D Research Studies
- Carbohydrate Chemistry and Synthesis
- Hormonal Regulation and Hypertension
- Celiac Disease Research and Management
- Mitochondrial Function and Pathology
- Thyroid Cancer Diagnosis and Treatment
- Trypanosoma species research and implications
- Hypothalamic control of reproductive hormones
- Thyroid and Parathyroid Surgery
- Adrenal Hormones and Disorders
- Diet and metabolism studies
- Digestive system and related health
- Thyroid Disorders and Treatments
- Viral Infections and Immunology Research
- Neonatal Health and Biochemistry
- Diabetes Management and Education
- Pregnancy and preeclampsia studies
- Iron Metabolism and Disorders
Mazandaran University of Medical Sciences
2016-2025
Iran University of Medical Sciences
2022
Tehran University of Medical Sciences
2022
Diabetes Research Center
2018-2021
Sina Hospital
2020
Abstract The objective of this research is to analyze the influence various factors on glycemic control in pediatrics with type 1 diabetes mellitus (T1DM). study, a cross-sectional analysis, involved 221 T1DM patients below 18 years old who visited our clinic between 2011 and 2020, predating COVID-19 outbreak. Out initial pool, 204 participants were chosen based specific criteria. By computing odds ratios 95% confidence intervals, we determined correlation these achieving optimal (HbA1c <...
Abstract Vitamin D‐dependent rickets type 1 (VDDRIA) is an autosomal recessive disorder caused by mutations in the Cytochrome P450 Family 27 Subfamily B Member (CYP27B1) gene, which encodes for enzyme alpha‐hydroxylase. We report a known case of VDDRIA with hypotonia, growth and developmental disorders discuss about mutation its management.
Discharge against medical advice from the hospital is an important issue point of view treatment management, health costs as well side effects stop on patients and their accompanying. Therefore, managers planners should consider predisposing factors that change patient's mind in this regard. Since, there has been no study to carefully assess rate causes self-discharge province, so aimed fill gap.This descriptive cross-sectional was carried out 6 months period, 23 July 2010 till 20 January...
BACKGROUND: Eczema, allergic rhinitis and asthma are common chronic disorders in childhood.AIM: The aim of this study was to determine the prevalence among Iranian guidance schools students Mazandaran Province, northern Iran.METHODS: This analytical cross-sectional performed on 3000 children aged 11â€14 years old during 2012â€13 according ISAAC study. Of recruited 1576 (52.54%) were female 1424 (47.46%) male. Data gathered by first phase questionnaire analysed SPSS software 20.RESULTS:...
There are more than 500 different mutations on phenylalanine hydroxylase (PAH) gene that is responsible for phenylketonuria (PKU) diseases and the spectrum of these varied in populations. The main clinical manifestation untreated patients severe mental retardation. PAH gene, 90 kb long, consisted 13 exons 12 introns. aim present study was to identify frequency five common among with PKU Mazandaran Golestan provinces including c.1066-11G>A, p. R261Q, R252W, R261X, c.1200 + 1G>C.Forty...
Classic phenylketonuria (PKU) is a metabolic disorder. The purpose of this study was to assess epidemiological factors PKU phenotypes in neonatal screening program for Mazandaran, Iran.In descriptive-retrospective from 2007 2015, neonates level conducted by phenylalanine based on biochemical technique ELISA and then confirmatory methods high performance liquid chromatography.Of the 407,244 screened newborns (48.7% girls 51.3% boys), 14 13 boys were diagnosed definitely 465 suspicious cases...
Abstract Objectives Type 1 diabetes is an autoimmune disease. Its most important immunologic markers are pancreatic beta-cell autoantibodies. This study aimed to determine mellitus antibodies frequency among children and adolescents with type diabetes. Methods descriptive evaluated the of four autoantibodies (glutamic acid decarboxylase 65 [GADA], islet cell [ICA], insulin [IAA], tyrosine phosphatase–like insulinoma antigen-2 [IA-2A]) their serum level in diagnosed at department Bou-Ali-Sina...
Abstract Background Mucopolysaccharidosis type I (MPSI) is a rare autosomal recessive disorder caused by deficiency of α‐ l ‐iduronidase (IDUA) encoded the IDUA gene. We examined mutation spectrum gene to explain clinical, biochemical, and molecular features in 21 Iranian patients with MPSI. Methods Sanger sequencing was used measure sequence coding region exon‐intron boundaries. recorded clinical findings studied at first diagnosis disease then during treatment follow‐up. Results Five...
Congenital hyperinsulinism (CHI) is a rare and life-threatening genetic disorder. Sirolimus as mammalian target of rapamycin inhibitor may be helpful in patients with CHI who do not respond well to other treatments including diazoxide octreotide. However, the safety efficacy this therapy are still unclear. This study aimed evaluate potential therapeutic effects sirolimus mutations ABCC8 KCNJ11 genes. During period follow-up study, every child confirmed diagnosis unresponsive underwent...
Mucopolysaccharidoses (MPSs) are rare, heterogeneous inborn errors of metabolism (IEM) diagnosed through a combination clinical, biochemical, and genetic investigations. The aim this study was molecular characterization the largest cohort Iranian MPS patients (302 from 289 unrelated families), along with tracking their ethnicity geographical origins. 185/289 were studied using an IEM-targeted NGS panel followed by complementary Sanger sequencing, which led to diagnosis 154 5 non-MPS IEMs...
Maturity-onset diabetes of the young (MODY), an autosomal dominant disease, is frequently misdiagnosed as type 1 or 2 diabetes. Molecular diagnosis essential to distinguish them. This study was done investigate prevalence MODY subtypes and patients' clinical characteristics.A total 43 out 230 individuals with were selected based on age >6 months, family history diabetes, absence marked obesity, measurable C-peptide. Next-generation direct SANGER sequencing performed screen MODY-related...
The Ochratoxin A(OTA) is a nephrotoxic and carcinogenic mycotoxin which generates important risks for human health worldwide owing to food contamination merchandise, environment. Dietary contaminants ingested by nursing mothers can be found in their breast milk. Nevertheless, the rate of OTA lactation transfer has not been investigated so far at various stages breastfeeding. study aimed assessing presence values A milk Isfahan, Iran, sought evaluate potential risk newborn babies based on...
Introduction: The prevalence of type 1 diabetes in all countries throughout the world is different. In this study, an introduction is, therefore, provided for development children Mazandaran province by using available resources.Methods: descriptive cross-sectional patients with initial diagnosis mellitus, aging from 6 months to 18 years, was located through contacting and referring organizations insurers doctors or experts endocrinologist adolescent diseases province.Results: 289 were...
Background: Glycogen storage disease type 1a (GSD-1a) is the most common form of GSDs, accounting for 80% these cases. Here we present a 16-month-old boy being treated GSD-1a at our clinic. Case presentation: Given that patient was not examined and diagnosed prior to referral clinic, mitochondrial due developmental delay, high lactate levels, lack hypoglycemia first. fact patient’s clinical presentation could be justified by repeat testing, DNA analysis showed evidence in favor...
Abstract Background Glycogen storage disease type IX is a rare disorder that can cause wide variety of symptoms depending on the specific deficiency phosphorylase kinase enzyme and organs it affects. Case presentation A 4-and-a-half-year-old Caucasian girl was referred to our clinic with liver biopsy report indicating diagnosis glycogen disease. Prior being clinic, patient had been under care pediatric gastroenterologists. The patient’s initial included chronic abdominal pain, constipation,...
Abstract Background: There are more than 1100 different pathogenic variants in the phenylalanine hydroxylase ( PAH ) gene that responsible for phenylketonuria (PKU) diseases, and spectrum of these mutations varies ethnic groups. The aim present study was to identify frequency all 13 exons among patients with PKU Mazandaran Golestan provinces north Iran. Methods: Forty unrelated from were enrolled study. Genomic DNA extracted leukocytes using a Qiagen extraction kit polymerase chain reaction...
Investigating Diabetes-associated Autoantibodies and Their Relationship to Clinical Characteristics in Children Diagnosed With Type 1 Diabetes