A5045732860- Analytical Chemistry and Chromatography
- Chromatography in Natural Products
- Protein purification and stability
- Mass Spectrometry Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Chemistry and Chemical Engineering
- Crystallization and Solubility Studies
- Process Optimization and Integration
- Neuropeptides and Animal Physiology
- Diabetes Treatment and Management
- Analytical Methods in Pharmaceuticals
- Pesticide Residue Analysis and Safety
- Helminth infection and control
- Receptor Mechanisms and Signaling
- Environmental Toxicology and Ecotoxicology
- Heavy metals in environment
- Animal Nutrition and Physiology
- Water Treatment and Disinfection
- Spectroscopy and Chemometric Analyses
- Biosimilars and Bioanalytical Methods
- Coal and Coke Industries Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Neuroscience of respiration and sleep
- Synthetic Organic Chemistry Methods
Merck & Co., Inc., Rahway, NJ, USA (United States)
1997-2023
Bristol-Myers Squibb (United States)
2017-2023
Merck Institute for Science Education
2017-2020
Merck (Japan)
2017
St Vincent's Hospital Sydney
1993
Manhattan College
1990
Abstract The toxicity of chemicals in sediments is influenced by the extent that bind to sediment. It shown acid volatile sulfide (AVS) sediment phase determines LC50 for cadmium marine tested. Although it well known metals can form insoluble sulfides, apparently has not been recognized AVS a reactive pool solid available with metals. Amphipod tests were conducted laboratory and observed amphipod LC50s on normalized concentration basis, [Cd]/[AVS], same over an order magnitude difference dry...
A single easy-to-use tool to provide a built-in quantitative way show how method choices impact greenness.
α,α-Diaryl primary amines are highly important chemical building blocks in agrochemical and pharmaceutical active ingredients. One of the limitations current chromatographic methodologies for these molecules is poor greenness factor as a result high solvent consumption to reach necessary productivity, well lack systematic approaches. Herein, we overcome challenges by introducing simple efficient enhanced sub/supercritical fluid chromatography (eSFC) approach that enables analysis...
Life cycle analysis allows comparison of RP-HPLC to SFC.
A novel series of pyrrolidine-containing GPR40 agonists is described as a potential treatment for type 2 diabetes. The initial pyrrolidine hit was modified by moving the position carboxylic acid, key pharmacophore GPR40. Addition 4-cis-CF3 to improves human binding Ki and agonist efficacy. After further optimization, discovery minor enantiomeric impurity with activity led finding that enantiomers (R,R)-68 (S,S)-68 have differential effects on radioligand used assay, potentiating displacing...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of Abamectin and/or Ivermectin in Cattle Feces at Low Parts per Billion Levels Using HPLC with Fluorescence DetectionLori D. Payne, Michael B. Hicks, and Teresa A. WehnerCite this: J. Agric. Food Chem. 1995, 43, 5, 1233–1237Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 1995https://pubs.acs.org/doi/10.1021/jf00053a021https://doi.org/10.1021/jf00053a021research-articleACS...
Quantifying the greenness of chromatographic separations using CO 2 in mobile phase.
The toxicity of chemicals in sediments is influenced by the extent that bind to sediment. It shown acid volatile sulfide (AVS) sediment phase determines LC50 for cadmium marine tested. Although it well known metals can form insoluble sulfides, apparently has not been recognized AVS a reactive pool solid available with metals. Amphipod tests were conducted laboratory and observed amphipod LC50s on normalized concentration basis, [Cd]/[AVS], same over an order magnitude difference dry weight...
A method was developed and validated to determine eprinomectin marker residue in bovine liver, kidney, muscle, fat. The overall percent recovery (± CV) 93 ± 12% (n = 66) for 100 13% 34) 87 42) 95 11% limit of detection 1 ng/g, the lower quantitation 2 upper 5000 ng/g (μg/kg). Accuracy, precision, linearity, selectivity, ruggedness were demonstrated. For determination, tissue is mixed with sodium sulfate, homogenized, extracted. reconstituted extract loaded onto an aminopropyl cartridge....
The use of a coulometric array detector in tandem with HPLC-UV was evaluated for the absolute quantitation pharmaceutical compounds without standards, an important capability gap contemporary research and development. high-efficiency LC flow-through electrochemical system allows rapid evaluation up to 16 different potentials, aiding identification electrochemically reactive species. By quantifying number electrons added or removed from analyte during its passage through detector, moles can...
Abstract Emamectin benzoate is a very effective agricultural insecticide applied to various crops at low rates. A method analyze emamectin in seawater and freshwater was developed. The yields good recoveries with limits of quantitation 20 pg/mL for 24 (signal-to-noise ratio [S/N] ≥ 10). limit detection 10 (S/N 3). benzoateis concentrated from 50 mL sample on C8 solid-phase extraction cartridge eluted 1% ammonium acetate methanol. eluate evaporated 1 mL, diluted % water, partitioned into...
Mutant isocitrate dehydrogenase 1 (IDH1) has been identified as an attractive oncology target for which >70% of grade II and III gliomas ∼10% acute myeloid leukemia (AML) harbor somatic IDH1 mutations. These mutations confer a neomorphic gain function, leading to the production oncometabolite (R)-2-hydroxyglutarate (2-HG). We developed potent, selective, orally bioavailable brain-penetrant tricyclic diazepine scaffold that inhibits mutant IDH1. During course in vitro metabolism studies,...
N-Nitrosamines are strictly regulated in pharmaceutical products due to their carcinogenic nature. Therefore, the ability rapidly and reliably identify N-nitroso functionality is urgently needed. Unfortunately, not all ionized compounds produce diagnostic fragment ions hence tandem mass spectrometry based on collision-activated dissociation (CAD) cannot be used consistently functionality. a more reliable method was developed functional-group selective ion-molecule reactions linear quadrupole...
Correction for ‘Making the move towards modernized greener separations: introduction of analytical method greenness score (AMGS) calculator’ by Michael B. Hicks <italic>et al.</italic>, <italic>Green Chem.</italic>, 2019, <bold>21</bold>, 1816–1826, DOI: 10.1039/C8GC03875A.