A5037554287- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Endometriosis Research and Treatment
- Vascular Malformations Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Surgical Sutures and Adhesives
- Infectious Encephalopathies and Encephalitis
- Restless Legs Syndrome Research
- Cytomegalovirus and herpesvirus research
- Endometrial and Cervical Cancer Treatments
- Intracranial Aneurysms: Treatment and Complications
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Sleep and Wakefulness Research
- Pharmacological Effects and Toxicity Studies
- Uterine Myomas and Treatments
- Diet and metabolism studies
- Nasal Surgery and Airway Studies
- Reconstructive Surgery and Microvascular Techniques
- Cerebrospinal fluid and hydrocephalus
- Brain Metastases and Treatment
- Neurological Complications and Syndromes
Faculdade de Ciências Médicas da Santa Casa de São Paulo
2016-2025
Universidade Federal de São Paulo
2016-2023
Hospital São Paulo
2008-2023
Beneficência Portuguesa de São Paulo
2018-2021
Faculdade de Medicina de São José do Rio Preto
2015
Hospital de Base
2015
Associação Fundo de Incentivo à Pesquisa
2012
Irmandade da Santa Casa de Misericórdia de São Paulo
2006-2012
Armed Forces Institute of Pathology
2012
Santa Casa Hospital
2006-2009
Brown adipose tissue (BAT) is predominantly regulated by the sympathetic nervous system (SNS) and adrenergic receptor signaling pathway. Knowing that a mouse with triple β-receptor knockout (KO) cold intolerant obese, we evaluated independent role played β 1 isoform in energy homeostasis. First, 30 min i.v. infusion of norepinephrine (NE) or selective agonist dobutamine (DB) resulted similar interscapular BAT (iBAT) thermal response WT mice. Secondly, mice targeted disruption gene (KO (β...
We describe two patients with a confirmed diagnosis of high-grade gliomas (grades III/IV), both presenting O6-methylguanine-DNA methyltransferase (MGMT) methylated and isocitrate dehydrogenase (IDH-1) mutated who, after subtotal resection, were submitted to chemoradiation followed by PCV, multiple drug regimen (procarbazine, lomustine, vincristine) associated cannabidiol (CBD). Both presented satisfactory clinical imaging responses at periodic evaluations. Immediately therapy, one the an...
BACKGROUND Cerebellar liponeurocytoma is a rare, low-grade neoplasm (WHO grade 2) characterized by neuronal or neurocytic differentiation and variable glial with lipoma-like alterations. First described in 1978 recognized the WHO classification 2000, it presents significant challenges radiological pathological differentiation. This crucial to avoid unnecessary deleterious treatments. OBSERVATIONS The patient presented symptoms including headache, dizziness, hiccups, nausea, vomiting,...
Previous reports have shown beneficial effects of pentoxifylline (PTX) and hypertonic saline (HS) in the treatment hemorrhagic shock. We compared these solutions to those conventional lactated Ringer's (LR) on bacterial translocation (BT), lung injury total differential cell count bronchoalveolar lavage fluid (BAL) after Rats (280-330 g) were bled a MAP 35 mmHg for 1 h then randomized into 4 groups: LR (3× shed blood); HS (7,5% NaCI, 4mL/kg); LR+PTX (25mg/kg) SHAM (no shock, no treatment)....
The brown adipose tissue (BAT) mediates adaptive changes in metabolic rate by responding to the sympathetic nervous system through β-adrenergic receptors (AR). Here, we wished define role played ARβ3 isoform this process. This study focused on knockout mice (ARβ3KO), including responsiveness cold exposure, diet-induced obesity, intolerance glucose, dyslipidaemia and lipolysis white (WAT). ARβ3KO defend core temperature during exposure (4°C for 5 h), with faster BAT thermal response...
To analyze retrospectively a series of patients with temporal lobe epilepsy (TLE) and mesial sclerosis (MTS), the association patterns hippocampal clinical data surgical prognosis.Sixty-six medically refractory TLE unilateral MTS after anterior lobectomy were included. Quantitative neuropathological evaluation was performed on NeuN-stained sections. Patient's outcome reviewed.Occurrence initial precipitating insult (IPI), as well better postoperative seizure control (i.e. Engel class 1),...
The aim of the current study was to investigate apoptosis neurons, astrocytes and immune cells from human patients that were infected with rabies virus by vampire bats bite. Apoptotic neurons identified their morphology using double immunostaining. There very few apoptotic present in tissue samples, but there an increase infiltrating CD4+ TCD8+ adaptive tissue. No NK, macrophage astrocytes. dissemination within host may be mediated viral escape cell involve anti-apoptotic mechanism, which...
Three types of beta adrenergic receptors (ARβ1-3) mediate the sympathetic activation brown adipose tissue (BAT), key thermogenic site for mice which is also present in adult humans. In this study, we evaluated adaptive thermogenesis and metabolic profile a mouse with Arβ2 knockout (ARβ2KO). At room temperature, ARβ2KO have normal core temperature and, upon acute cold exposure (4 °C 4 h), accelerate energy expenditure normally attempt to maintain body temperature. exhibited interscapular BAT...
Analyse technical aspects, effectiveness and morbidity of the endoscopic endonasal transphenoidal approach for pituitary adenomas.From January 2005 to September 2008, 30 consecutive patients underwent resection adenomas with a follow up from 3 36 months. Their medical charts were retrospectively analysed.There 18 women 12 men, mean age 44 years (range 17-65 yr). Among patients, 23 had macroadenomas 7 microadenomas. Twelve non-functioning tumors, 9 ACTH-secreting 8 GH-secreting tumors 1...
OBJECTIVE: To describe five cases of giant carotid cavernous aneurysms which evolved with spontaneous thrombosis internal artery (STICA), emphasis at epidemiology, clinical presentation, natural history, related factors and neurological outcome. METHOD: There were 711 consecutives patients 802 without surgical treatment during a period 19 years. We selected 35 40 (5%) 20 (50%) aneurysms. Among those cases, 5 STICA (25%). Symptoms findings presentation recorded compared RESULTS: Clinical was...
The aim of this retrospective study a series patients with mesial temporal lobe epilepsy (MTLE) and sclerosis (MTS) was to analyze the association granule cell dispersion (GCD) surgical prognosis, patterns MTS clinical data. Hippocampal specimens from 66 MTLE unilateral 13 controls were studied. Quantitative neuropathological evaluation performed on NeuN-stained hippocampal sections. Patients' data, types outcome reviewed. GCD occurred in 45.5% cases not correlated variable. More severe...
Fractionation of the EtOH extract from aerial parts Baccharis uncinella C. DC. (Asteraceae) led to isolation caffeic and ferulic acids, which were identified spectroscopic spectrometric evidence. These compounds exhibit antioxidant anti-inflammatory properties have been shown be effective in prevention/treatment metabolic syndrome. This study investigated whether combined treatment acids exhibits a more significant beneficial effect mouse model with The combination was tested for 60 days C57...
Supratentorial Lymphocytic Inflammation with Parenchymal Perivascular Enhancement Responsive to Steroids (SLIPPERS) is a rare variant of the CLIPPERS spectrum less than ten reports published so far. There ongoing discussion regarding whether SLIPPERS disease entity on its own or just an acronym encompassing many underlying diagnoses, such as sarcoidosis, vasculitis and anti-glial fibrillary acidic protein (GFAP)-associated disease. A 40-year-old woman presented episodes language attention...
The objective was to study the morphology of articular disc and analyse immunohistochemical expression types I III collagen markers in temporomandibular joint (TMJ) human foetuses different gestational ages. Twenty TMJ from supplied by Universidade Federal de Uberaba with ages 17 24 weeks were studied. age determined measuring crown-rump (CR) length. Macroscopically, fixed 10% formalin solution dissected removing skin subcutaneous tissue exposing deep structures. Immunohistochemical type...