A5033173412- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Synthesis and Catalytic Reactions
- Carbon dioxide utilization in catalysis
- Catalytic Cross-Coupling Reactions
- CO2 Reduction Techniques and Catalysts
- Radical Photochemical Reactions
- Catalytic Alkyne Reactions
- Asymmetric Hydrogenation and Catalysis
- Oxidative Organic Chemistry Reactions
- Chemical synthesis and alkaloids
South China University of Technology
2020-2023
A Pd-catalyzed highly regioselective hydrocarboxylation of alkynes with carbon dioxide has been established. By the combination Pd(PPh3)4 and 2,2′-bis(diphenylphosphino)-1,1′-binaphthalene (binap), a variety functionalized alkynes, including aryl aliphatic propargylamines, propargyl ethers, could be leveraged to provide wide array α-acrylic acids in high yields regioselectivity under mild reaction conditions. Experimental DFT mechanistic studies revealed that this proceeded via...
Abstract Carbonylation coupling reaction has emerged as a powerful and versatile strategy for the construction of carbonyl‐containing compounds in modern synthetic chemistry over past years. Carbon dioxide, renewable one carbon molecule, become most attractive promising alternative carbonyl sources due to its highly abundance, nontoxicity stability comparison with CO recent However, cases, two‐chamber technique was generally necessary allow CO‐producing CO‐consuming processes perform...
Abstract Introducing the primary amino group into aromatic ring is one of most important study issues in organic chemistry, particularly for pharmaceuticals and agrochemicals chemistry. Herein, we describe a photoinduced direct C−H amination arenes with ammonia via site‐selective thianthrenation that forms new C−N bond excellent regioselectivity. The reaction carried out under mild conditions, wide range functional tolerance, such as sensitive −Cl, −Br, −OH groups which are poorly tolerated...
Abstract A multicomponent strategy to achieve two different regioselectivities from alkynes, isothiocyanates and H 2 O with a proton acid/ N ‐chlorophthalimide (NCPI) system is described selectively obtain non‐aromatic five‐membered sulfur heterocycles (1,3‐oxathiol‐2‐imines/thiazol‐2(3 )‐one derivatives) through multiple bond formations. The process features readily available starting materials, mild reaction conditions, broad substrate scope, good functional‐group tolerance, high regio‐...
A novel, Pd-catalyzed oxidative Heck reaction of non-activated alkenes synergistically directed by bifunctional groups has been developed firstly using O2 as a green oxidant, yielding the products with excellent yields in regio- and stereoselective manner. This synergistic activation mechanism was demonstrated experimental analysis detailed computational studies, wherein hydroxyl group directs migratory insertion trifluoromethyl facilitates subsequent β-H elimination reductive elimination....
Abstract A multicomponent strategy to achieve two different regioselectivities from alkynes, isothiocyanates and H 2 O with a proton acid/ N ‐chlorophthalimide (NCPI) system is described selectively obtain non‐aromatic five‐membered sulfur heterocycles (1,3‐oxathiol‐2‐imines/thiazol‐2(3 )‐one derivatives) through multiple bond formations. The process features readily available starting materials, mild reaction conditions, broad substrate scope, good functional‐group tolerance, high regio‐...
A copper-catalyzed Ullmann-type C-N cross-coupling reaction of carbazole with aryl chlorides has been developed employing N,N′ -bis(thiophene-2-ylmethyl)oxalamide as ligand. The proceeds at 140 °C Cs 2 CO 3 the base in DMSO/MeCN to afford N -arylcarbazole good excellent yields. Both heteroaromatic ring and amide structures ligands are important for their efficiency.