A5030793529- Trace Elements in Health
- Lipid Membrane Structure and Behavior
- Heavy Metal Exposure and Toxicity
- Autophagy in Disease and Therapy
- Sirtuins and Resveratrol in Medicine
- GDF15 and Related Biomarkers
- Hippo pathway signaling and YAP/TAZ
- Molecular Sensors and Ion Detection
- Electrochemical Analysis and Applications
- Ubiquitin and proteasome pathways
- Pneumonia and Respiratory Infections
- CRISPR and Genetic Engineering
- Cancer-related gene regulation
- Neuroscience of respiration and sleep
- Mercury impact and mitigation studies
- Machine Learning in Bioinformatics
- Neonatal Respiratory Health Research
- Membrane Separation Technologies
- Computational Drug Discovery Methods
- Nanoparticles: synthesis and applications
- Genetics and Neurodevelopmental Disorders
- Influenza Virus Research Studies
- Cannabis and Cannabinoid Research
- Cancer, Hypoxia, and Metabolism
- Tea Polyphenols and Effects
University of Alberta
2020-2025
University of Calgary
2016-2018
The emergence of severe acute respiratory syndrome coronavirus 2, the causative agent disease 2019, has resulted in largest pandemic recent history. Current therapeutic strategies to mitigate this have focused on development vaccines and drugs that inhibit viral 3CL protease or RNA-dependent RNA polymerase enzymes. A less-explored potentially complementary drug target is Nsp15, a uracil-specific endonuclease shields coronaviruses other nidoviruses from mammalian innate immune defenses. Here,...
Resveratrol (3,4,5-Trihydroxy-trans-stilbene) is a naturally occurring polyphenol that exhibits beneficial pleiotropic health effects. It one of the most promising natural molecules in prevention and treatment chronic diseases autoimmune disorders. One key limitations clinical use resveratrol its extensive metabolic processing to glucuronides sulfates. has been estimated around 75% this excreted via feces urine. To possibly alleviate improve bioavailability, we have added segments...
This study presented a novel screening of acrylamides discovering them as inhibitors against Nsp15 from SARS-CoV-2 and utilizing the data to develop an AI model screen more virtually.
Inorganic mercury and cadmium are becoming increasingly prevalent due to industrial activity have been linked cardiovascular disease diabetes. The binding affinity of Hg, Cd, their mixtures biomimetic erythrocyte membranes was investigated by isothermal titration calorimetry in physiologically relevant media (100 mM NaCl, pH 7.4, 37 °C). thermodynamic parameters were not expressed per mole lipid but as metals liposomes. To our knowledge, this method is novel provides a more intuitive...
Nicotinamide adenine dinucleotide (NAD+) plays a vital role in cellular processes that govern human health and disease. phosphoribosyltransferase (NAMPT) is rate-limiting enzyme NAD+ biosynthesis. Thus, boosting level via an increase NAMPT levels attractive approach for countering the effects of aging metabolic This study aimed to establish IRW (Ile-Arg-Trp), small tripeptide derived from ovotransferrin, as booster levels. Treatment muscle (L6) cells with increased intracellular protein...
Abstract MOTS‐c (mitochondrial ORF of the twelve S-c) is a 16-amino-acid mitochondrial peptide that has been shown to counter insulin resistance and alleviate obesity in vivo. However, mechanisms involved pharmacological action MOTS-c remain elusive. Based on ability improve promote cold adaptation, we hypothesized might play role boosting number mitochondria cell. We found treatment mammalian cells with increased protein levels TFAM, COX4, NRF1, which are markers for biogenesis. flow...
Tubby-like proteins (TULPs) are characterized by a conserved C-terminal domain that binds phosphoinositides. Collectively, mammalian TULP1-4 play essential roles in intracellular transport, cell differentiation, signaling, and motility. Yet, little is known about how the function of these regulated cells. Here, we present protein–protein interaction network TULP3, protein responsible for trafficking G-protein-coupled receptors to cilia whose aberrant expression associated with severe...
The renal proximal tubule (PT) is the major target of cadmium (Cd 2+ ) toxicity where Cd causes stress and apoptosis. Autophagy induced by cell stress, e.g. endoplasmic reticulum (ER) may contribute to survival or death. role autophagy in ‐induced nephrotoxicity remains unsettled due contradictory results lack evidence for autophagic machinery damage . rat kidney PT line NRK‐52E its death was investigated. markers LC3‐II p62 indicate rapid induction flux (5–10μM) after 1h, accompanied ER...
Abstract Background : The function of the Ras association domain family 1 (RASSF1)/modulator apoptosis (MOAP-1) molecular tumor suppressor pathway is often perturbed in many solid and blood cancers by epigenetic loss RASSF1A via promoter specific methylation. However, a detailed analysis expression stability MOAP-1 as well effect on cellular proliferation cell death has not been explored. Methods Expression was performed immunoblotting analysis, biology determined proliferation,...
Abstract Objective: The function of the Ras association domain family 1 (RASSF1)/modulator apoptosis (MOAP-1) molecular tumor suppressor pathway is often perturbed in many solid and blood cancers by epigenetic loss RASSF1A via promoter specific methylation. However, a detailed analysis expression stability MOAP-1 as well effect on cellular proliferation cell death has not been explored. Materials Methods: Expression was performed immunoblotting analysis, biology determined proliferation,...