A5049660528- Hemoglobinopathies and Related Disorders
- Chronic Lymphocytic Leukemia Research
- Iron Metabolism and Disorders
- Chronic Myeloid Leukemia Treatments
- Platelet Disorders and Treatments
- Blood groups and transfusion
- Hemophilia Treatment and Research
- Eosinophilic Disorders and Syndromes
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Digital Imaging for Blood Diseases
- Acute Lymphoblastic Leukemia research
- Cancer Treatment and Pharmacology
- Immunodeficiency and Autoimmune Disorders
- Neonatal Health and Biochemistry
- Parvovirus B19 Infection Studies
- Neutropenia and Cancer Infections
- Healthcare and Environmental Waste Management
- Liver Disease Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Erythrocyte Function and Pathophysiology
- Chemotherapy-related skin toxicity
- Blood Coagulation and Thrombosis Mechanisms
- CNS Lymphoma Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
Vivekananda Institute of Medical Sciences
2021-2024
Medical College and Hospital, Kolkata
2013-2023
Care India
2022
Nil Ratan Sircar Medical College and Hospital
2014-2021
Milton Keynes Hospital
2021
AMRI Hospitals
2021
University College Hospital
2019
University College London
2019
S.N. Bose National Centre for Basic Sciences
2017
Institute of Post Graduate Medical Education and Research
2002-2015
A 24-year-old previously healthy girl presented with persistent fever, headache, and jaundice. Rapid-test anti-dengue virus IgM antibody was positive but IgG nonreactive, which is suggestive of primary dengue infection. There clinical deterioration during empiric antibiotic symptomatic therapy. Bone marrow examination demonstrated the presence hemophagocytosis. Diagnosis fever virus-associated hemophagocytic syndrome made according to diagnostic criteria HLH 2004 protocol Histiocyte Society....
Background Mutations in the ABL kinase domain and SH3-SH2 of BCR/ABL gene amplification Philadelphia chromosome are two important dependent mechanisms imatinib resistance. Here, we intended to study role played by TKI, imatinib, selection mutations development chromosomal abnormalities Indian CML patients. Methods Direct sequencing methodology was employed detect conventional cytogenetics done identify duplication. Results Among different resistance, (39%) were seen be more prevalent,...
Burkholderia cepacia, an aerobic gram-negative bacillus, is a frequent colonizer of fluids used in the hospital ward. It poses little risk infection to healthy people; however it known important opportunistic pathogen causing morbidity and mortality due its intrinsic resistance most antibiotics hospitalized patients. Small outbreaks are frequent. B. cepacia may occur as hemato-oncology Here we present outbreak hematology ward our institute.Febrile episodes defined by IDSA guideline, 2010...
Abstract Introduction Emicizumab is the initial subcutaneously administered bispecific antibody approved as a prophylactic treatment for patients with haemophilia A (PwHA). Aim This study assessed economic evaluation of emicizumab non‐inhibitor severe (HA) in India. Methods Markov model evaluated cost‐effectiveness prophylaxis compared to on‐demand therapy (ODT), low‐dose (LDP; 1565 IU/kg/year), intermediate‐dose (IDP; 3915 IU/kg/year) and high‐dose (HDP; 7125 HA without factor VIII...
The exact role of the different transcript variants BCR-ABL in pathogenesis chronic myeloid leukemia (CML) and their impact on prognosis is yet to be definitely enumerated.In this study, we have tried correlate presenting features, risk scores treatment response with detected our patients.A cross-sectional unicentric hospital-based study 80 patients diagnosed CML by bone marrow cytogenetics confirmed reverse transcriptase-polymerase chain reaction (RT-PCR).RT-PCR for was performed...
Objective: Careful screening of bilirubin level in newborns is mandatory as per American Academy Pediatrics (2004), to reduce incidents kernicterus and acute encephalopathy. Although, invasive capillary collection blood subsequent biochemical test considered a gold standard for jaundice detection neonates, transcutaneous measurement using various non-invasive instruments also used sporadically across the globe. The major aim this study was develop spectrometry-based technique neonatal an...
Anemia severely and adversely affects human health socioeconomic development. Measuring hemoglobin with the minimal involvement of financial resources has always been challenging. We describe a translational spectroscopic technique for noncontact measurement at low-resource point-of-care settings in subjects, independent their skin color, age, sex, by measuring optical spectrum blood flowing vascular bed bulbar conjunctiva. developed software on LabVIEW platform automatic data acquisition...
According to the 2008 revision of World Health Organization (WHO) classification myeloid malignancies, philadelphia chromosome (Ph)-negative myeloproliferative neoplasms (MPNs) include clonal, hematologic disorders such as polycythemia vera, primary myelofibrosis, and essential thrombocythemia.Recent years have witnessed major advances in understanding molecular pathophysiology these rare subgroups chronic, disorders. Identification somatic mutations genes associated with pathogenesis...
Objective of this paper: Early detection anemia (low hemoglobin count) at point-of-care (PoC) in a low resource setting is challenging given the associated capital and recurring costs device. In paper, we have developed faster reliable method to screen level whole blood limited point care setting. We also investigated simple scattering-based technique predict overall morphology red cells. Methods: validated digital camera-based spectrometer for early with 10-μL volume PoC The device consists...
Molecular breakpoint of the BCR-ABL fusion gene has been characterized for 122 chronic myeloid leukemia patients. Out cases, 33 b2a2, 69 b3a2, 2 e1a2, and e19a2 cases have detected. Six coexpressed both b2a2 b3a2 transcripts. All coexpressing samples had an A>G polymorphism at putative splice branchpoint in intron 13. The T>C exon 13, reported to be linked coexpression, was not present all No correlation transcript type with platelet count Those expressing were diagnosed relatively younger...
A 26-year-old previously healthy female presented with a 6-month history of anemia. The laboratory findings revealed hemolytic anemia and direct antiglobulin test was positive. With diagnosis autoimmune (AIHA), prednisolone started but ineffective after 1 month therapy. bone marrow trephine biopsy pure red cell aplasia (PRCA) showing severe erythroid hypoplasia. case considered PRCA following AIHA. This combination without clear underlying disease is rare. Human parvovirus B19 infection not...
Over the past 20 years, hydroxyurea (HU) has emerged as an important therapeutic agent to augment Hb F and thus total hemoglobin (Hb) in E [β26(B8)Glu→Lys; HBB: c.79G>A]-β-thalassemia (Hb E-β-thal), albeit used varying doses with little consensus on its optimal dose. We report interim analysis findings of a broader study assess impact Comprehensive Thalassemia Care, which present was part. Sixty-one E-β-thal patients who were transfusion independent or requiring occasional transfusions...
Chronic Myeloid Leukemia (CML) constitutes around 3% of leukemia in the children and adolescent age group.The aim study was to evaluate characteristics at presentation treatment outcome CML group.Retrospective analysis carried out a single center India.Thirteen patients (≤17 years) attending outdoor from April 2008 August 2012 were included analysis.The mean median various parameters calculated using Microsoft excel sheet. SPSS 16.0 version software used calculate OS PFS.CML-CP most common...
Immune thrombocytopenia (ITP) is primarily considered a bleeding disorder; its impact on patients' health-related quality of life (HRQoL) under-recognized. We aimed to assess how aligned patient and physician perceptions are regarding ITP-associated symptoms, HRQoL, disease management in India.Patients physicians (hematologists/hemato-oncologists) from India who participated the global ITP World Impact Survey (I-WISh) were included this subgroup analysis (survey). Physicians recruited via...
Physicians establish diagnosis by assessing a patient's signs, symptoms, age, sex, laboratory test findings and the disease history. All this must be done in limited time against backdrop of an increasing overall workload. In era evidence-based medicine it is utmost important for clinician to abreast latest guidelines treatment protocols which are changing rapidly. resource settings, updated knowledge often does not reach point-of-care. This paper presents artificial intelligence (AI)-based...
Helicobacter pylori urease activity is a potential source of ammonia in the stomach patients with cirrhosis. However, possible role H. pathogenesis hepatic encephalopathy deserves further investigations. The current study evaluates relationship among infection, gastric juice concentrations, and arterial levels Overall, 14 cirrhosis overt encephalopathy, 19 subclinical 13 without were enrolled. All underwent upper endoscopy, biopsy specimens taken for assessment (rapid test, histology,...
This report describes two patients with chronic myeloid leukaemia (CML): one of them developed accelerated phase CML and died 8 years after diagnosis the other is at phase. Sequence analysis reverse transcription-polymerase chain reaction products showed presence BCR–ABL fusion transcript e19a2. finding suggests that carrying μ-BCR breakpoint may exhibit a clinical course similar to typical CML.
Acute promyelocytic leukemia (APL) constitutes about 15% of all acute myeloid patients and can now be treated even without any chemotherapy, with all-trans-retinoic acid (ATRA) arsenic trioxide (ATO). pancreatitis (AP) is a rare adverse event in APL, which primarily reported to secondary hypertriglyceridemia. Here, we have AP developed patient during induction ATRA ATO, but it was not associated Rather, respiratory distress weight gain, coincidental leukocytosis, bilateral pleural effusion,...