A5063567312- Cardiovascular and exercise physiology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Exercise and Physiological Responses
- Adenosine and Purinergic Signaling
- Heart Rate Variability and Autonomic Control
- Respiratory Support and Mechanisms
- Cardiovascular Effects of Exercise
- Autophagy in Disease and Therapy
- Advanced Chemical Sensor Technologies
- Nutrition and Health in Aging
- High Altitude and Hypoxia
- Hemodynamic Monitoring and Therapy
- Heart Failure Treatment and Management
- Thermoregulation and physiological responses
- Ultrasound in Clinical Applications
- Extracellular vesicles in disease
- Cardiovascular Health and Disease Prevention
- Phonocardiography and Auscultation Techniques
- Blood Pressure and Hypertension Studies
- Eicosanoids and Hypertension Pharmacology
- Peripheral Artery Disease Management
- Inhalation and Respiratory Drug Delivery
Mayo Clinic
2020-2024
University of Utah
2021-2024
Mayo Clinic in Arizona
2016-2024
The University of Sydney
2024
National Health and Medical Research Council
2024
Royal Prince Alfred Hospital
2024
Geriatric Research Education and Clinical Center
2021-2023
George E. Wahlen Department of VA Medical Center
2021-2023
Mayo Clinic in Florida
2018-2021
WinnMed
2020
Exhaustive exercise can induce unique physiological responses in the lungs and other parts of human body. The volatile organic compounds (VOCs) exhaled breath are ideal for studying effects exhaustive on due to proximity matrix respiratory tract. As VOCs originate from bloodstream, changes abundance should also indicate broader Currently, there is limited published data VOCs. Breath has great potential biomarker analysis as it be collected non-invasively, capture real-time metabolic better...
Despite a growing body of literature on the physiological responses to ultramarathon, there is paucity data in females. This study assessed female response ultramarathon and compared frequency perturbations group race- time-matched males.Data were collected from 53 contestants an trail race at Ultra-Trail du Mont-Blanc (UTMB®) 2018/19. Before within 2 h finish, participants underwent assessments, including blood sampling for biomarkers (creatine kinase-MB isoenzyme [CK-MB], cardiac troponin...
This unique case study details the impact of SARS-CoV-2 infection on vascular and skeletal muscle function in a young predominantly presymptomatic woman. Prior to COVID-19 diagnosis, substantial reductions vascular, muscle, mitochondrial were observed along with an elevation IL-10. integrative indicates that is widespread may help elucidate acute long-term sequelae this disease.
Background Hemodynamic perturbations in heart failure with preserved ejection fraction (HFpEF) may alter the distribution of blood lungs, impair gas transfer from alveoli into pulmonary capillaries, and reduce lung diffusing capacity. We hypothesized that impairments capacity for carbon monoxide (DLCO) HFpEF would be associated high mean capillary wedge pressures during exercise. Methods Results Rebreathe DLCO invasive hemodynamics were measured simultaneously exercise patients exertional...
Abstract Aim The importance of endothelial cell (EC) autophagy to vascular homeostasis in the context health and disease is evolving. Earlier, we reported that intact EC requisite maintain shear-stress-induced nitric oxide (NO) generation via glycolysis-dependent purinergic signalling NO synthase (eNOS). Here, illustrate translational functional significance these findings. Methods results First, assessed relevance using older male humans mice exhibit blunted impaired arterial function vs....
Patients with heart failure preserved ejection fraction (HFpEF) experience symptoms of exertional dyspnea that may be related to lung fluid accumulation during exercise. A computed tomography (CT)-based method was used measure exercise-induced changes in extravascular content and thoracic blood volumes determine the effect on diffusing capacity for carbon monoxide (DLCO) stable subjects HFpEF healthy controls. Nine (age = 68 ± 8 yr; body mass index 32.1 2.6 kg/m2) eight controls (62 9 yr,...
Abstract Aims The effect of extravascular lung water (EVLW) and relationship to functional status as a result acute decompensated heart failure (ADHF) are not well understood. We sought quantify changes in clinical variables, EVLW, airway anatomy, spirometry, diffusing capacity for carbon monoxide before after treatment ADHF. Methods results Fifteen patients were recruited within 24 h hospital admission. Spirometry, monoxide, surrogates EVLW by computed tomography measured then repeated...
Parks, Jordan K, Courtney M. Wheatley-Guy, Glenn Stewart, Caitlin C. Fermoyle, Bryan J. Taylor, Jesse Schwartz, Briana Ziegler, Kay Johnson, Alice Gavet, Loïc Chabridon, Paul Robach, and Bruce D. Johnson. Lung “Comet Tails” in healthy individuals: accumulation or clearance of extravascular lung water? High Alt Med Biol. 24:230–233, 2023—Ultrasound comet tails (or B-lines) tend to be limited number (<5) absent under ultrasound examination, the appearance diffuse B-lines with sliding has been...
The age-related increase in α-adrenergic tone may contribute to decreased leg vascular conductance (LVC) both at rest and during exercise the old. However, effect on passive movement (PLM)-induced LVC, a measure of function, which is markedly attenuated this population, unknown. Thus, eight young (25 ± 5 yr) seven old (65 7 subjects, investigation examined impact systemic β-adrenergic blockade (propanalol, PROP) alone, PROP combined with either α
Endurance exercise at altitude can increase cardiac output and pulmonary vascular pressure to levels that may exceed the stress tolerability of alveolar-capillary unit. This study examined effect ultramarathon trail racing different altitudes (ranging from <1000 m between 1500 2700 m) on recruitment lung diffusion.
Aging alters the shear rate profile in arm, characterized by increased oscillatory (bidirectional) shear, potentially from progressive increases sympathetic nervous system activity. However, extent to which atheroprone vasculature of leg is mediated overactivity via α-adrenergic receptor activation unknown. We sought determine how pharmacological modulation activity femoral artery with aging. hypothesized, within leg, that vasoconstriction would lead a pro-atherosclerotic young adults while...
Introduction: Leg immobilization results in substantial losses muscle mass and strength. Strategies aimed at minimizing these have proven largely ineffective. Elevated oxidative stress has been identified as a potential mechanism contributing to losses. Therefore, we tested the hypothesis that PB125, an activator of Nrf2 (the master regulator endogenous antioxidant system), MitoQ, mitochondrial-targeted antioxidant, would decrease deleterious effects limb on Methods: A double-blind,...
With the introduction of antifibrotic drugs targeting progressive pulmonary fibroses, it becomes imperative to provide reliable contemporary estimates most common interstitial lung diseases. We aimed incidence and survival idiopathic fibrosis (IPF), hypersensitivity pneumonitis (HP) connective tissue disease-associated disease (CTD-ILDs), compare their that general population. To do this we have used data extracted from Optimum Patient Care Research Database (OPCRD). In matched cohort study,...
<b>Introduction:</b> The pulmonary circulation is characterized by low pressures, such that RV & alveolar-capillary membrane stress are low. On the contrary, strenuous exercise increases cardiac output (Q) artery/capillary pressure to levels may exceed a tolerable load of stress. Accordingly, this study examined effect an ultramarathon on function, recruitment lung diffusion. <b>Methods:</b> Cardiac function were at rest during 3 stages low-intensity in 19 runners (Age:40±9yr...
Vascular dysfunction, an independent risk factor for cardiovascular disease, often persists in patients with hypertension, despite improvements blood pressure control induced by antihypertensive medications.As some of these medications may directly affect vascular function, this study sought to comprehensively examine the impact reducing pressure, a nonpharmacological approach (5 days sodium restriction), on function 22 hypertensive individuals (14 men/8 women, 50 ± 10 years). Following...
Abstract Objective The importance of endothelial cell (EC) autophagy to vascular homeostasis is evolving. Earlier we reported that purinergic 2Y 1 receptor (P2Y -R) activation rejuvenates shearstress induced nitric oxide (NO) generation in bovine aortic cells otherwise compromised after pharmacological and genetic repression. Here determined the translational functional relevance these findings. Approach Results First assessed using older humans mice exhibit blunted EC at rest together with...
PURPOSE: Heart failure is often associated with abnormal pulmonary hemodynamics. Pulmonary arterial capacitance (PAC) a measure of the distensibility vasculature and determinant right ventricular afterload. Previously it has been shown that, at rest, PAC demonstrates hyperbolic relationship vascular resistance (PVR) in heart (HF) patients an independent predictor mortality. Our aim was to determine how exercise affects its capacity indices respiratory gas exchange. METHODS: 39 HF undergoing...
Previous studies have reported increases in oxidative stress due to reductions antioxidant enzymes calcified regions of stenotic human aortic valves. Whether are adaptive, maladaptive, or an epiphenomenon calcifying valves remains unclear. Thus, the purpose this study was test whether overexpression catalase reduces valvular calcification and slows progression valve stenosis mice. Wild type (WT) mice with calcific disease (ldlr-deficient, apoB100-only) were crossed transgenic that...