A5091522081- Hydrogels: synthesis, properties, applications
- Sphingolipid Metabolism and Signaling
- Inflammatory mediators and NSAID effects
- Advanced Materials and Mechanics
- Synthesis and biological activity
- Glycosylation and Glycoproteins Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Spine and Intervertebral Disc Pathology
- Supramolecular Self-Assembly in Materials
- Surface Modification and Superhydrophobicity
- Immune cells in cancer
- Adhesion, Friction, and Surface Interactions
- Advanced Sensor and Energy Harvesting Materials
- Polymer Surface Interaction Studies
- Nitric Oxide and Endothelin Effects
- Polymer-Based Agricultural Enhancements
- biodegradable polymer synthesis and properties
- Glutathione Transferases and Polymorphisms
- Infant Nutrition and Health
- Pancreatic function and diabetes
- Wireless Body Area Networks
- Management of metastatic bone disease
- Proteoglycans and glycosaminoglycans research
- Cervical and Thoracic Myelopathy
- Facial Nerve Paralysis Treatment and Research
Georgia Institute of Technology
2019-2025
Stanford University
2018
University of Illinois Chicago
2017
Hunan Children's Hospital
2011
University of Chicago
2006-2007
Triangle
2007
Communities In Schools of Orange County
2007
Material properties gradually degrade under cyclic loading, leading to catastrophic failure. It results in large costs for inspection, maintenance, and downtime. Besides, materials require combinations of performance such as load bearing energy dissipation. However, improving one a material often sacrifices another performance, making it difficult create with optimal profiles. Here we report liquid-infused porous piezoelectric scaffold (LIPPS) that simultaneously enhances its load-bearing...
Abstract Inducibly degradable polymers present new opportunities to integrate tough hydrogels into a wide range of biomaterials. Rapid and inducible degradation enables fast transition in material properties without sacrificing integrity prior removal. In pursuit bioorthogonal chemical modalities that will enable polymer biologically relevant environments, enamine N ‐oxide crosslinkers are developed for double network acrylamide‐based polymer/alginate hydrogels. Bioorthogonal dissociation...
Entomopathogenic nematodes (EPNs) exhibit a bending-elastic instability, or kink, before becoming airborne, feature previously hypothesized but not substantiated to enhance jumping performance. Here, we provide the evidence that this kink is crucial for improving launch We demonstrate EPNs actively modulate their aspect ratio, forming liquid-latched α-shaped loop over slow timescale <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" overflow="scroll"> <mml:mrow>...
Abstract Injectable hydrogels represent a promising strategy for the extended release of biological molecules, thereby reducing frequency injections. This study introduces novel system based on Michael addition dextran and polyethylene glycol (PEG) polymers functionalized with oxanorbornadiene (OND) thiol groups, respectively. Reliable control over gelation speed allows administration by injection using simple syringe‐to‐syringe mixing protocol that entrains more than 95% virus‐like particle...
Abstract A polymeric gel contains a crosslinked polymer network and solvent. Gels can swell or shrink in response to external stimuli. Two typical kinetic processes are involved during the deformation of gels: viscoelastic poroelastic responses. Viscoelasticity gels is generated from local rearrangement polymers, while poroelasticity solvent migration. The coupled time-dependent behaviors be formulated by coupling spring-dashpot model with diffusion–deformation model. Different combinations...
Midkine (MDK) is a cytokine and neurotrophic factor that more highly expressed in the brains of alcoholics mice predisposed to drink large amounts ethanol, suggesting MDK may regulate ethanol consumption. Here we measured consumption male female Mdk knockout (-/-) using two-bottle choice drinking dark (DID) tests. We found -/- consumed significantly than wild-type controls both To determine if acts ventral tegmental area (VTA) consumption, delivered lentivirus expressing shRNA into VTA...
Objectives Pulsed electromagnetic field (PEMF) stimulation was evaluated after anterior cervical discectomy and fusion (ACDF) procedures in a randomized, controlled clinical study performed for United States Food Drug Administration (FDA) approval. PEMF significantly increased rates at six months, but 12-month outcomes subjects elevated risk pseudoarthrosis were not thoroughly reported. The objective of the current to evaluate effect treatment on ACDF procedures. Methods Two evaluations that...
Abstract The successful processing of bilayer protective coatings on plastics using a combined spray and atmospheric plasma deposition method is shown. base layer deposited coating with high adhesion (3‐glycidyloxypropyl) trimethoxysilane tetrapropyl zirconate (TPOZ) precursors. top dense by tetraethyl orthosilicate precursor. rate, chemical composition, elastic modulus, hardness, to poly(methyl methacrylate) (PMMA) substrates are investigated. the polymer substrate found decrease increasing...
Objective: To compare the clinical effects of robot-assisted minimally invasive transforaminal lumbar interbody fusion (TLIF) and traditional open TLIF in treatment spondylolisthesis. Methods: A total 41 patients with spondylolisthesis accepted surgical Department Spinal Surgery Beijing Jishuitan Hospital From July 2015 to April 2016 were retrospectively analyzed. There 16 cases 25 TLIF. The operation time, X-ray radiation exposure perioperative bleeding, drainage volume, time...
Growth factor (GF) mimicry involves recapitulating the signaling of larger molecules or cells. Although GF holds considerable promise in tissue engineering and drug design applications, difficulties targeting molecule to site delivery dissociation mimicking peptides from their target receptors continue limit its clinical application. To address these challenges, we utilized a self-assembling peptide (SAP) platform generate synthetic insulin-like growth (IGF)-signaling, GFs. Our hydrogels are...
We applied solid- and solution-state nuclear magnetic resonance spectroscopy to examine the structure of multidomain peptides composed self-assembling β-sheet domains linked bioactive domains. Bioactive can be selected stimulate specific biological responses (e.g., via receptor binding), while β-sheets provide desirable nanoscale properties. Although previous work has established efficacy peptides, molecular-level characterization is lacking. The are intended remain solvent-accessible...
<h3>Rationale</h3> Acylglycerol kinase (AGK) phosphorylates monoacylglycerol and diacylglycerol to form potent lipid second messengers, lysophosphatidic acid (LPA) phosphatidic (PA), respectively. We have shown earlier that LPA induces transactivation of epidermal growth factor receptor (EGF-R) in human bronchial epithelial cells (HBEpCs). Here we provide evidence for the role AGK LPA-mediated expressions COX-2 IL-8 involving EGF-R HBEpCs. <h3>Methods/Results</h3> Expression HBEpCs was...