A5103095361- Supramolecular Self-Assembly in Materials
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- Blood Coagulation and Thrombosis Mechanisms
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- Biopolymer Synthesis and Applications
- Pancreatic function and diabetes
- Health Systems, Economic Evaluations, Quality of Life
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- Pharmaceutical Economics and Policy
- Platelet Disorders and Treatments
- Tissue Engineering and Regenerative Medicine
- Infant Nutrition and Health
- Influenza Virus Research Studies
- Protease and Inhibitor Mechanisms
- Cellular Mechanics and Interactions
- Electrospun Nanofibers in Biomedical Applications
- Advanced NMR Techniques and Applications
- Lipoproteins and Cardiovascular Health
- Glycosylation and Glycoproteins Research
New Jersey Institute of Technology
2023-2024
Rabindranath Tagore International Institute of Cardiac Sciences
2020-2022
Indian Association for the Cultivation of Science
2018-2020
The lasting threat of viral pandemics necessitates the development tailorable first-response antivirals with specific but adaptive architectures for treatment novel infections. Here, such an antiviral platform has been developed based on a mixture hetero-peptides self-assembled into functionalized β-sheets capable multivalent binding to protein complexes. One domain each hetero-peptide is designed specifically bind certain proteins, while another self-assembles fibrils epitope...
The triple-negative phenotype is the most prevalent form of human breast cancer worldwide and characterized by poor survival, high aggressiveness, recurrence. Microvesicles (MV) are shredded plasma membrane components critically mediate cell-cell communication, but can also induce proliferation metastasis. Previous studies have revealed that protease-activated receptor 2 (PAR2) contributes significantly to (TNBC) progression releasing nano-size MV promoting cell proliferation, migration,...
Apart from blood coagulation, coagulation proteases are involved inextricably in cancer progression/propagation via intra/inter‐cellular signaling, mediated predominantly by protease‐activated receptors (PARs). Microvesicles (MVs), a plasma membrane shredded component, has recently been identified as an important contributor to human breast metastasis. However, the role of PAR2 promoting MVs generation cells remains largely unexplored. The objective this study is investigate whether...
Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide, especially in aging metabolically unhealthy populations. A target regenerative tissue engineering the restoration viable cardiomyocytes to preserve cardiac function circumvent progression heart failure post-MI. Amelioration ischemia crucial component such restorative strategies. Angiogenic β-sheet peptides can self-assemble into thixotropic nanofibrous hydrogels. These syringe aspiratable cytocompatible gels...
Atorvastatin-80mg/day and Rosuvastatin-40mg/day are the commonest high-dose statin (3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors) regimes for post-PCI (Percutaneous Coronary Interventions) patients to lower (by ≥50%) blood low-density-lipoprotein cholesterol (LDL-C). Dearth of conclusive evidence from developing world, regarding overall safety, tolerability comparative effectiveness (outcome/safety/tolerability/endothelial inflammation control) Rosuvastatin over Atorvastatin in...
Growth factor (GF) mimicry involves recapitulating the signaling of larger molecules or cells. Although GF holds considerable promise in tissue engineering and drug design applications, difficulties targeting molecule to site delivery dissociation mimicking peptides from their target receptors continue limit its clinical application. To address these challenges, we utilized a self-assembling peptide (SAP) platform generate synthetic insulin-like growth (IGF)-signaling, GFs. Our hydrogels are...
We applied solid- and solution-state nuclear magnetic resonance spectroscopy to examine the structure of multidomain peptides composed self-assembling β-sheet domains linked bioactive domains. Bioactive can be selected stimulate specific biological responses (e.g., via receptor binding), while β-sheets provide desirable nanoscale properties. Although previous work has established efficacy peptides, molecular-level characterization is lacking. The are intended remain solvent-accessible...
Abstract Funding Acknowledgements Type of funding sources: None. Background Differential expression microRNAs is critical in the genesis and progression atherosclerosis. MiR145 has atheroprotective role through improved homeostasis smooth muscle cells (SMC). MiR155 pro-atherogenic due to its suppression Bcl6, which antagonises NF-κB modulates macrophages. Purpose Our purpose was determine if differential miR 155 & 145 (expressed as 155:145 ratio) across various age groups risk factor...