A5047234153- Ethics in Clinical Research
- Academic integrity and plagiarism
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Law, AI, and Intellectual Property
- Palliative Care and End-of-Life Issues
- Colorectal Cancer Screening and Detection
- Cancer Cells and Metastasis
- Mitochondrial Function and Pathology
- Biomedical Ethics and Regulation
- Data Analysis and Archiving
- Genetics and Neurodevelopmental Disorders
- Empathy and Medical Education
- Plant Molecular Biology Research
- Neurobiology and Insect Physiology Research
- Patient Dignity and Privacy
- Italian Fascism and Post-war Society
- Science, Research, and Medicine
- ATP Synthase and ATPases Research
- Qualitative Research Methods and Ethics
- Physiological and biochemical adaptations
- Mental Health and Psychiatry
University of Bergamo
2007-2023
University of Münster
2021-2023
University of Amsterdam
2020
Amsterdam University Medical Centers
2020
Amsterdam UMC Location University of Amsterdam
2018
Abstract Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis of all common cancers. However, divergent outcomes exist between patients, suggesting distinct underlying tumor biology. Here, we delineated this heterogeneity, compared interconnectivity classification systems, and experimentally addressed biology that drives poor outcome. RNA-sequencing 90 resected specimens unsupervised revealed four subgroups associated with outcomes. The worst-prognosis subtype was characterized by...
Abstract Neuronal development and function are known to be among the most energy-demanding functions of body. Constant energetic support is therefore crucial at all stages a neuron’s life. The two main adenosine triphosphate (ATP)-producing pathways in cells glycolysis oxidative phosphorylation. Glycolysis has relatively low yield but provides fast ATP enables metabolic versatility needed dividing neuronal stem cells. Oxidative phosphorylation, on other hand, highly efficient thought provide...
Does there exist only one, universally valid, research ethic? Are informed consent and ethical committees the best means to ensure moral correctness of research? Again, what consequences ensue from introduction these instruments for freedom quality its results? This article addresses issues by first recounting an ethnography conducted author in oncology department a large Italian hospital. To carry out his initially had conceal identity purpose presence patients. Only later was this mode...
To reshape neuronal connectivity in adult stages, Drosophila sensory neurons prune their dendrites during metamorphosis using a genetic degeneration program that is induced by the steroid hormone ecdysone. Metamorphosis nonfeeding stage imposes metabolic constraints on development. We find AMP-activated protein kinase (AMPK), regulator of energy homeostasis, cell-autonomously required for dendrite pruning. AMPK activated ecdysone and promotes oxidative phosphorylation pyruvate usage, likely...
Consequences of the awareness approaching death have been studied mainly in relation to patients. Much less attention has paid role family members. The article describes tragic consequences that concealing prognosis and not telling truth patients on relations Italy. For this purpose, author recounts story 6 months illness preceded his father's from cancer.
: Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis of all common cancers, but strongly divergent outcomes are apparent between patients. To reveal and address intertumor heterogeneity that contributes to this, we have performed RNA-Seq gene expression analysis on a large number resected PDAC samples (n=90). Unsupervised class discovery in this single-center PDAC-only dataset identified four subgroups with distinct clinical manifestations. Biological interpretation network...