A5003488307- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Dermatology and Skin Diseases
- Eosinophilic Disorders and Syndromes
- Urticaria and Related Conditions
- Eosinophilic Esophagitis
- Pediatric health and respiratory diseases
- Contact Dermatitis and Allergies
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Mast cells and histamine
- Diabetes and associated disorders
- Respiratory and Cough-Related Research
- Celiac Disease Research and Management
- Immunodeficiency and Autoimmune Disorders
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Infant Nutrition and Health
- Angiogenesis and VEGF in Cancer
- Autoimmune Bullous Skin Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Olfactory and Sensory Function Studies
Centre Hospitalier Universitaire de Rennes
2023-2025
Université de Rennes
2025
Policlinico San Matteo Fondazione
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
Foundation Center
2011-2023
Hôpital Pontchaillou
2023
University of Pavia
2013-2022
University Hospital Foundation
2007-2018
Agostino Gemelli University Polyclinic
2014
University of Genoa
2009
The release of neutrophil extracellular traps (NETs), a process termed NETosis, avoids pathogen spread but may cause tissue injury. NETs have been found in severe COVID-19 patients, their role disease development is still unknown. aim this study to assess the capacity drive epithelial-mesenchymal transition (EMT) lung epithelial cells and analyze involvement COVID-19. Bronchoalveolar lavage fluid patients showed high concentration that correlates with neutrophils count; moreover, analysis...
T helper (Th)-17 cells are a subset of lymphocytes that exert regulatory activities. Recently, it has been reported serum interleukin (IL)-17 levels high in the most severe cases birch allergy studied outside pollen season.The aim this study was to investigate possible relationship between IL-17 and clinical parameters patients with allergic rhinitis during season.In all, 56 persistent pollen-induced were evaluated season. Serum by enzyme-linked immunosorbent assay. Symptoms assessed visual...
<b><i>Objectives:</i></b> This study included a cohort of advanced renal cell carcinoma patients treated with sunitinib. Since resistance to sunitinib may be mediated through angiogenic cytokines other than VEGF, we measured the circulating levels three pro-angiogenic cytokines: basic fibroblast growth factor (bFGF), hepatocyte (HGF), and interleukin (IL)-6. <b><i>Methods:</i></b> Cytokines were at baseline on first day each treatment cycle...
Aging is accompanied by a progressive decline in almost all functions of the immune system. To investigate possible impact age on IgE production, this study evaluated total and allergen-specific serum levels large cohort allergic patients. This included 6,370 patients (2,961 females, 3,409 males; mean age, 21.7 years; range, 0-96 years). Total were measured immunoenzymatic assay. The analysis variance showed significant difference (P<0.0001) value among different groups Moreover, specific...
Anti-IgE treatment represents a major breakthrough in the therapeutic management of severe allergic asthma. To date, omalizumab is only biological drug currently licensed as add-on therapy children aged > 6 years with moderate-to-severe and asthma uncontrolled after high dose inhaled corticosteroids plus long-acting beta2-agonist. The clinical efficacy safety pediatric population has been extensively documented specific trials consistently expanded from real-life studies. Our aim to describe...
Rationale Whole lung lavage (WLL) is a widely accepted palliative treatment for autoimmune pulmonary alveolar proteinosis (aPAP) but does not correct myeloid cell dysfunction or reverse the pathological accumulation of surfactant. In contrast, inhaled recombinant granulocyte–macrophage colony-stimulating factor (rGM-CSF) promising pharmacological approach that restores macrophage functions including surfactant clearance. Here, we evaluate WLL followed by rGM-CSF (sargramostim) as therapy...
The correct diagnosis of neonatal sepsis is a relevant problem because one the most important causes morbidity, mortality, and prolonged hospital stay. Calprotectin an antimicrobial, calcium zinc binding heterocomplex protein that could be used as nonspecific marker for activation granulocytes mononuclear phagocytes. has been proposed inflammatory conditions. Our aim to study serum calprotectin biomarker diagnosis.41 (20 females, 21 males) infants who underwent blood culture due suspected...
Allergic rhinitis (AR) is a common disorder. The diagnosis based on the concordance between allergy sensitization and history. Serum allergen specific immunoglobulin E (sIgE) assessment allows characterization of relevant sensitizing allergens. Presently, Rhinitis its Impact Asthma (ARIA) classification subdivides AR symptoms severity duration. However, relationship sIgE levels symptom still matter debate.Therefore, this study aimed at relating with assessed by ARIA in group patients AR.We...
The poor availability of kidney for transplantation has led to a search new strategies increase the donor pool. main option is use organs from extended criteria donors. We evaluated effects hypothermic oxygenated perfusion (HOPE) with and without extracellular vesicles (EV) derived mesenchymal stromal cells on ischemic/reperfusion injury marginal kidneys unsuitable transplantation. For normothermic reperfusion (NR), we used artificial blood as substitute red cells. global renal ischemic...
Summary Objectives Autoimmune targeting of hypothalamic‐neurohypophyseal structures in children and young adults with posterior pituitary anterior dysfunction, as well stalk involvement, are not yet completely understood. Design We aimed to (1) evaluate the presence circulating vasopressin‐cell autoantibodies (AVPc‐Abs) patients central diabetes insipidus (CDI), (2) detect organ‐specific markers autoimmunity, (3) define relationship between immune neuroimaging findings. Patients Twenty were...
Myeloma plasma cells interact with the bone marrow microenvironment which, in turn, supports their growth and protects them from apoptosis. In vitro studies have demonstrated antitumor potential of zoledronic acid (ZOL) on myeloma cell lines, but few data are available its effects stromal (BMSCs). The aim current study was to evaluate antiproliferative apoptotic effect ZOL BMSCs, as well expression adhesion molecules.BMSCs, obtained mononucleated 8 patients multiple myeloma, were treated...
We studied plasma erythropoietin (EPO) levels and their relation with CD34+VEGFR-2+ (mature progenitor endothelial cells) CD34+ CD133+VEGFR-2+, or CD117+VEGFR-2+ (early/immature progenitors) cells in patients acute myocardial infarction (AMI). Fifty AMI undergoing percutaneous coronary intervention (PCI) within 6 h of symptom onset were enrolled. EPO, measured by ELISA, cell subsets, cytofluorimetric analysis, evaluated before PCI, 24 7 days afterwards. Forty-five healthy subjects (CTRLs)...
Abstract: Atopic dermatitis (AD) is an inflammatory disorder of the skin characterized by impaired immune response. Th9 cells are a sub‐population T that release interleukin (IL)‐9. No study has investigated role IL‐9 in AD. This compared 64 children with AD 45 healthy children. Serum levels were measured and clinical symptoms assessed. Children had higher serum than controls (p = 0.01). Clinical severity was significantly related to level, indicating might exert pathogenic symptom...
Dendritic cells (DC) play a key role in cell-mediated immunity. We aimed to analyse the number and function of peripheral blood (PB) myeloid plasmacytoid DC (mDC/pDC) patients with severe sepsis.Twenty-six septic patients, 20 surgical (abdominal aortic aneurysm) healthy controls were enrolled this prospective study.At day 1 (enrollment study), showed comparison controls, decreased mDC (P < 0.001) increased pDC = 0.03), resulting reduction mDC/pDC ratio 0.001). Surgery induced decrease both...