A5091754626- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Medical Imaging Techniques and Applications
- RNA modifications and cancer
- Chronic Lymphocytic Leukemia Research
- Genetic Syndromes and Imprinting
- Genomics and Phylogenetic Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Ubiquitin and proteasome pathways
- Drug Transport and Resistance Mechanisms
- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Immune Cell Function and Interaction
- Molecular Biology Techniques and Applications
- Gene expression and cancer classification
- interferon and immune responses
- Chronic Myeloid Leukemia Treatments
- Lipid metabolism and biosynthesis
- Autoimmune and Inflammatory Disorders Research
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Protein Degradation and Inhibitors
- Cancer-related gene regulation
University of Oslo
2017-2024
Abstract JASPAR (http://jaspar.genereg.net/) is an open-access database containing manually curated, non-redundant transcription factor (TF) binding profiles for TFs across six taxonomic groups. In this 9th release, we expanded the CORE collection with 341 new (148 plants, 101 vertebrates, 85 urochordates, and 7 insects), which corresponds to a 19% expansion over previous release. We added 298 Unvalidated when no orthogonal evidence was found in literature. All were clustered provide...
JASPAR (https://jaspar.elixir.no/) is a widely-used open-access database presenting manually curated high-quality and non-redundant DNA-binding profiles for transcription factors (TFs) across taxa. In this 10th release 20th-anniversary update, the CORE collection has expanded with 329 new profiles. We updated three existing provided orthogonal support 72 from previous release's UNVALIDATED collection. Altogether, 2024 update provides 20% increase in release. A trimming algorithm enhanced by...
Abstract Methylation of cytosines on DNA is a prominent modification associated with gene expression regulation. Aberrant methylation patterns have recurrently been linked to dysregulation the regulatory program in cancer cells. To shed light underlying molecular mechanism driving this process, we hypothesised that aberrant could be controlled by binding specific transcription factors (TFs) across types. By combining arrays and data TF sites (TFBSs), explored interplay between 19 We...
The transcription factor c-Myb is involved in early differentiation and proliferation of haematopoietic cells, where it operates as a regulator self-renewal multi-lineage differentiation. Deregulated plays critical roles leukaemias other human cancers. Due to its role master regulator, we hypothesized might function pioneer factor. Our approach test this was analyse mutant c-Myb, D152V, previously reported cause defects mice by an unknown mechanism. transcriptome data from K562 cells...
MYB plays a key role in gene regulation throughout the hematopoietic hierarchy and is critical for maintenance of normal stem cells (HSC). Acquired genetic dysregulation involved etiology number leukemias, although inherited noncoding variants are susceptibility factor many hematological conditions, including myeloproliferative neoplasms (MPN). The mechanisms that connect variations levels to disease predisposition, especially concerning age dependency initiation, completely unknown. Here,...
The transcription factor MYB is a master regulator in haematopoietic progenitor cells and pioneer affecting differentiation proliferation of these cells. Leukaemic transformation may be promoted by high levels. Despite much accumulated molecular knowledge MYB, we still lack comprehensive understanding its target genes chromatin action. In the present work, performed ChIP-seq analysis K562 accompanied detailed bioinformatics analyses. We found that occupies both promoters enhancers. Five...
SUMOylation is a post-translational modification frequently found on nuclear proteins, including transcription factors (TFs) and coactivators. By controlling the activity of several TFs, may have far-reaching effects. MYB an example developmental TF subjected to SUMO-mediated regulation, through both SUMO conjugation binding. How affects target genes unknown. Here, we explored global effect reduced its downstream gene programs. RNA-Seq in K562 cells after knockdown rescue with mutants having...
The cholesterol-sensing nuclear receptor liver X (LXR) and the glucose-sensing transcription factor carbohydrate responsive element-binding protein (ChREBP) are central players in regulating glucose lipid metabolism liver. More knowledge of their mechanistic interplay is needed to understand role pathological conditions like fatty disease insulin resistance. In current study, LXR ChREBP co-occupancy was examined by analyzing ChIP-seq datasets from mice livers. interaction determined...
Abstract Methylation of cytosines on DNA is a prominent modification associated with gene expression regulation. Aberrant methylation patterns have recurrently been linked to dysregulation the regulatory program in cancer cells. To shed light underlying molecular mechanism driving this process, we hypothesized that aberrant could be controlled by binding specific transcription factors (TFs) across types. By combining arrays and data TF sites (TFBSs), explored interplay between 19 We...
ABSTRACT The cholesterol-sensing nuclear receptor liver X (LXR) and the glucose-sensing transcription factor carbohydrate responsive element-binding protein (ChREBP) are central players in regulating glucose lipid metabolism liver. We have previously shown that LXR regulates ChREBP activity; however, underlying mechanisms unclear. In current study, we demonstrate LXRα ChREBPα interact physically, show a high co-occupancy at regulatory regions mouse genome. co-activates ChREBPα,...
ABSTRACT The Myb transcription factor plays critical roles in normal and malignant hematopoiesis. Acquired genetic dysregulation of Myb, which a central role hematopoietic stem cell (HSC) gene regulation, is involved the etiology number leukemias. Also, inherited non-coding variants are susceptibility to many hematological conditions, including myeloproliferative neoplasms (MPN), but mechanisms by variations levels predispose disease, age-dependency disease occurrence, completely unknown....