A5060338579- Immune Cell Function and Interaction
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- Antibiotic Resistance in Bacteria
- Landslides and related hazards
- Ubiquitin and proteasome pathways
- Urbanization and City Planning
- Photosynthetic Processes and Mechanisms
- Cell Adhesion Molecules Research
- Bacterial biofilms and quorum sensing
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Cells and Metastasis
- HIV Research and Treatment
- Plant Pathogenic Bacteria Studies
- Enzyme Production and Characterization
- Microbial Natural Products and Biosynthesis
- Fire effects on ecosystems
- Immunotherapy and Immune Responses
- Archaeology and Natural History
- RNA modifications and cancer
- Systemic Lupus Erythematosus Research
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2023-2024
Feinstein Institute for Medical Research
2020-2023
Institute of Molecular Medicine
2022
University at Buffalo, State University of New York
2020
Hofstra University
2020
Hauptman-Woodward Medical Research Institute
2018
Biosynthesis of the hydroxamate siderophore aerobactin requires activity four proteins encoded within iuc operon. Recently, we biochemically reconstituted biosynthetic pathway and structurally characterized IucA IucC, two enzymes that sequentially couple N6-acetyl-N6-hydroxylysine to primary carboxylates citrate. IucC are members a family non-ribosomal peptide synthetase-independent (NIS) synthetases involved in production other siderophores, including desferrioxamine, achromobactin,...
HIV-1 infection is characterized by a strong inflammatory environment, tissue disruption, and progressive decline in CD4+ T cell count. Despite treatment with antiretroviral therapy (ART), the majority of persons living HIV (PLWH) maintain residual levels inflammation, low degree immune activation, higher sensitivity to death their memory T-cell compartment. To date, mechanisms responsible for this high remain elusive. We have identified transcription factor IRF-5 be involved impairing...
Summary Despite the progress made in identifying cellular factors and mechanisms that predict progression metastasis, breast cancer remains second leading cause of death for women US. Using The Cancer Genome Atlas mouse models spontaneous invasive mammary tumorigenesis, we identified loss function interferon regulatory factor 5 (IRF5) is a predictor metastasis survival. Histologic analysis Irf5 -/- glands revealed expansion luminal myoepithelial cells, organized glandular structure, altered...
Abstract Toll-like receptors (TLRs) represent a subset of pattern-recognition (PRRs) employed by the innate immune system to detect pathogen-associated molecular patterns (PAMPs) and initiate response invading microbes. The transcription factor interferon regulatory 5 (IRF5) functions as an important mediator inflammatory downstream MyD88-dependent TLR activation. While dysregulation IRF5 activity has been implicated in development several autoimmune diseases including systemic lupus...
Abstract The transcription factor IRF5 modulates human B cell activation, proliferation, and plasmablast differentiation via an intrinsic mechanism. Targeted knockdown of in primary naïve cells revealed a significant reduction CD19+CD86+ cells, which demarcate early activated after BCR/TLR9 stimulation, resulting reduced clonal expansion differentiation. mechanism(s) by activation is not known. We previously found that BCR stimulation alone was insufficient to induce nuclear translocation...
Abstract Generation of antibody secreting cells (ASCs) requires multiple B cell activation pathways, including receptor (BCR), T (TCR), and Toll-like receptors (TLRs). In human naïve cells, we reported that knockdown interferon regulatory factor 5 (IRF5) resulted in IgD retention, reduced proliferation plasma differentiation, IgG secretion. Defects were due to early impairments clonal expansion. Conversely, murine Irf5 was regulate production through direct control class switch recombination...
Abstract The recruitment of leukocytes to sites infection is an essential component the innate immune response pathogens. Defects in leukocyte migration can render host susceptible recurrent infections. In our efforts identify new mediators immunity, we found that serine/threonine protein kinase 25 (STK25) promotes TLR-induced proinflammatory cytokine production. While STK25 has previously been implicated regulation cell migration, its role trafficking not defined. To investigate involvement...
Abstract Toll-like receptors (TLRs) represent a subset of pathogen-recognition (PRRs) employed by the innate immune system to detect pathogen-associated molecular patterns (PAMPs) and initiate response invading microbes. The transcription factor interferon regulatory 5 (IRF5) functions as an important mediator inflammatory downstream myeloid differentiation 88 (MyD88)-dependent TLR activation. While dysregulation IRF5 activity has been implicated in development several autoimmune diseases...