A5046142579- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Drug Transport and Resistance Mechanisms
- Birth, Development, and Health
- Metabolism and Genetic Disorders
- Immune Cell Function and Interaction
- Neonatal Health and Biochemistry
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Metabolomics and Mass Spectrometry Studies
- Pregnancy and preeclampsia studies
- Infant Nutrition and Health
- Immune cells in cancer
- T-cell and B-cell Immunology
- RNA Research and Splicing
- Erythrocyte Function and Pathophysiology
- Pediatric Hepatobiliary Diseases and Treatments
- Neuroscience of respiration and sleep
- Cancer-related molecular mechanisms research
- Gestational Diabetes Research and Management
- Epigenetics and DNA Methylation
- Pluripotent Stem Cells Research
- Organ and Tissue Transplantation Research
- Mitochondrial Function and Pathology
- DNA and Nucleic Acid Chemistry
Memorial Sloan Kettering Cancer Center
2019-2025
Texas Tech University Health Sciences Center
2020-2022
Texas Tech University
2022
Cancer Research UK
2019
University of Cambridge
2017-2019
Kettering University
2019
Cancer Research UK Cambridge Center
2017-2018
ATUM (United States)
2018
University of California, Berkeley
2017-2018
Providence VA Medical Center
1982-2000
NF-κB-inducing kinase (NIK) mediates non-canonical NF-κB signaling downstream of multiple TNF family members, including BAFF, TWEAK, CD40, and OX40, which are implicated in the pathogenesis systemic lupus erythematosus (SLE). Here, we show that experimental NZB/W F1 mice can be treated with a highly selective potent NIK small molecule inhibitor. Both vitro as well vivo, inhibition recapitulates pharmacological effects BAFF blockade, is clinically efficacious SLE. Furthermore, also affects T...
Natural Killer (NK) cells confer protection from tumors and infections by releasing cytotoxic granules pro-inflammatory cytokines upon recognition of diseased cells. The responsiveness NK to acute stimulation is dynamically tuned steady-state receptor-ligand interactions an cell with its cellular environment. Here, we demonstrate that in healthy WT mice the activating receptor NKG2D engaged vivo one ligands, RAE-1ε, which expressed constitutively lymph node endothelial highly induced on...
The Homotransplantation of Kidneys and Fetal Liver Spleen after Total Body Irradiation: PDF Only
Article Figures and data Abstract Introduction Results Discussion Materials methods Data availability References Decision letter Author response author information Metrics A substantial fraction of the genome is transcribed in a cell-type-specific manner, producing long non-coding RNAs (lncRNAs), rather than protein-coding transcripts. Here, we systematically characterize transcriptional dynamics during hematopoiesis hematological malignancies. Our analysis annotated de novo assembled...
Abstract PAX3-FOXO1, an oncogenic transcription factor, drives a particularly aggressive subtype of rhabdomyosarcoma (RMS) by enforcing gene expression programs that support malignant cell states. Here we show PAX3-FOXO1 + RMS cells exhibit altered pyrimidine metabolism and increased dependence on enzymes involved in de novo synthesis, including dihydrofolate reductase (DHFR). Consequently, display sensitivity to inhibition DHFR the chemotherapeutic drug methotrexate, this is rescued...
Changes in peripheral plasma catecholamines were studied during varying degrees of hypoxemia fetal lambs 95–140 days gestation. Epinephrine and norepinephrine concentrations measured by radioenzymatic assay obtained simultaneously from the distal aorta inferior vena cava 15 chronically catheterized fetuses with mother breathing 20, 10, or 8% oxygen mixtures. Levels both epinephrine increased significantly after 5 min showed a strong inverse exponential correlation PO2 (P less than 0.001)....
Although the existence of a circadian periodicity plasma corticosteroid levels is well documented in man, few studies have been performed surgical patients relating alterations rhythmicity adrenocortical function to procedures. The present study used frequent sampling techniques examine effects varying types surgery on secretory pattern adrenocorticosteroids. In 10 patients, 36–65 yr old, blood was drawn from superficial vein every 20 min for 2 24-h periods: 1 beginning 48 h before surgery,...
Cholate metabolism was studied in fetal dogs 1 wk before term and compared with cholate adult dogs. Tracer amounts of sodium cholate-(14)C were administered to the fetus utero by intravenous infusion over 6 hr. Fetal plasma disappearance, biliary excretion, tissue distribution, placental transfer measured 10 Infused cleared rapidly from principally liver a minor extent mother. The taurine conjugate formed excreted into proximal small intestine via tree. Indirect evidence for functioning...
Bilirubin metabolism was studied in dog and monkey fetuses. Bilirubin-(3)H administered to fetal animals utero by prolonged intravenous infusion. Fetal plasma disappearance, hepatic uptake, biliary excretion, placental transfer of bilirubin-(3)H were measured.Bilirubin excretion the fetus much less efficient than adult. levels tritium elevated for periods, combined rate lower normal values adult excretion. Species differences noted. Hepatic conjugation appeared be primary mechanism dog. In...
Long non-coding RNAs (lncRNAs) show patterns of tissue- and cell type-specific expression that are very similar to those protein coding genes consequently have the potential control stem progenitor fate decisions along a differentiation trajectory. To understand roles lncRNAs may play in hematopoiesis, we selected subset mouse with potentially relevant refined our candidate list using evidence conserved human blood lineages. For each candidate, assessed its possible role hematopoietic vivo...
Abstract A good experimental model for metastasis of human pancreatic cancer would be a valuable tool the study this process, which contributes significantly to morbidity and mortality. Models using injection tumor cells into portal or systemic circulation bypass some important steps metastatic process. We describe invasion following orthotopic transplantation carcinoma nude mice. Tumor pieces were used as xenografts in study, metastases observed regional lymph nodes, liver, lungs, distant...
The intestinal absorption of sodium taurocholate was studied in the near-term fetal and neonatal dog. Absorption rates were measured vivo isolated loops jejunum ileum. also vitro everted sacs rings maximal observed after instillation 1 micronmol into closed segments ileum with intact blood supply not significantly different (P less than 0.2), equalled 0.282+/-0.026 (mean+/-SEM) 0.347+/-0.051 micronmol/h per 10-cm segment length ileum, respectively. Similarly, from open perfused 0.4 1.0 mM...
Bile salt metabolism was studied in fetal dogs 1 wk before term. The size and distribution of the bile pool were measured, individual salts identified. hepatic excretion endogenous fistula fetuses, capacity this excretory mechanism investigated by i.v. infusion a load sodium taurocholate-(14)C up to 20 times size. total 30.9+/-2.7 mumoles, which two-thirds gallbladder. Expressed on body weight basis, equal approximately one-half estimated adult dog (119.2+/-11.3 vs. 247.5+/-33.1 mumoles/kg...
The Homotransplantation of Kidneys and Fetal Liver Spleen after Total Body Irradiation: PDF Only
A new method for quantifying adrenal secretory function in chronically catheterized fetal lambs was developed. This preparation included insertion of a catheter distally into the left renal vein and placement remotely operated, hydraulically controlled choker around at its junction with vena cava. With open, venous blood flowed then closed, so that timed samples effluent could be obtained. this technique, rates norepinephrine epinephrine were determined across spectrum oxygen concentrations...