A5024489795- Nutritional Studies and Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Consumer Attitudes and Food Labeling
- Fatty Acid Research and Health
- Nutrition, Genetics, and Disease
- Gut microbiota and health
- Genetic Associations and Epidemiology
- Cerebrovascular and Carotid Artery Diseases
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Diet, Metabolism, and Disease
- Obesity, Physical Activity, Diet
- Advanced Proteomics Techniques and Applications
- Immune responses and vaccinations
- Nutrition and Health in Aging
- Fibroblast Growth Factor Research
- AI in cancer detection
- Radiology practices and education
- Cholesterol and Lipid Metabolism
- Radiomics and Machine Learning in Medical Imaging
University of Milan
2021-2024
Ospedale Bassini
2021-2024
European Institute of Oncology
2023
Eli Lilly (Singapore)
2023
Daiichi Sankyo (Germany)
2023
Daiichi-Sankyo (South Korea)
2023
Merck (Germany)
2023
Bayer (United States)
2023
Amgen (United States)
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2023
Background and purpose: Accurate instance segmentation of teeth in panoramic dental X-rays is a challenging task due to variations tooth morphology overlapping regions. In this study, we propose new algorithm, for instance, the different X-rays. Methods: An model was trained using architecture Mask Region-based Convolutional Neural Network (Mask-RCNN). The data training, validation, testing were taken from Tuft database (1000 radiographs). number predicted label 52 (20 deciduous 32...
Background High fat diet (HFD) chronically hyper-activates the myeloid cell precursors, but whether it affects neutrophil aging is unknown. Purpose We characterized how HFD impacts aging, infiltration in metabolic tissues and if this turn, modulates development of alterations. immunophenotyped neutrophils responses physiology (wild-type mice, WT) mice with constitutively aged (MRP8 driven conditional deletion CXCR4; herein CXCR4fl/flCre+) or fresh CXCR2; CXCR2fl/flCre+), following 20 weeks...
Gut Microbiota (GM) dysbiosis associates with Atherosclerotic Cardiovascular Diseases (ACVD), but whether this also holds true in subjects without clinically manifest ACVD represents a challenge of personalized prevention. We connected exposure to diet (self-reported by food diaries) and markers Subclinical Carotid Atherosclerosis (SCA) individual taxonomic functional GM profiles (from fecal metagenomic DNA) 345 previous ACVD. Subjects SCA reported consuming higher amounts cereals, starchy...
Background: Cardiovascular risk stratification in primary prevention is a clinical challenge. We recently identified large set of circulating proteins improving the prediction for cardiovascular events. now evaluate which these predicts development subclinical carotid atherosclerosis (SCA) prevention. Methods: Three hundred sixty-eight were quantified, by proximity extension assay, from plasma collected at basal visit 586 subjects without previous events and preclinical atherosclerosis....
Unhealthy dietary habits and highly caloric foods induce metabolic alterations promote the development of inflammatory consequences obesity, insulin resistance, diabetes cardiovascular diseases. Describing an effect diet is difficult to pursue, owing lacks standardized quali-quantitative assessments. The Dietary Inflammatory Index (DII) has been proposed as estimator pro- or anti-inflammatory nutrients higher DII values, which indicate increased intake with pro-inflammatory effects, relate...
Adherence to the Mediterranean diet (MedDiet) is recommended for cardiovascular disease prevention. However, recent epidemiological studies report a shift toward lower adherence MedDiet. We have conducted prospective cohort study evaluate changes in individual determinants of MedDiet over time. Clinical information and score (MEDAS) were collected 711 subjects (mean age 68 ± 10 years; 42% males), enrolled PLIC (Progression Intimal Atherosclerotic Lesions Carotid arteries), during two visits...
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main source(s): Italian Ministry Health - Progetti di Rilevante Interesse Nazionale (PRIN); European Commission PNRR Missione 4 (Progetto CN3 National Center for Gene Therapy and Drugs based on RNA Technology); MUSA- Multilayered Urban Sustainability Action; 6 Background High Fat Diets (HFDs) promote inflammation in cardio-metabolic diseases by epigenetically activating the inflammasome inducing an...
Abstract Background and aim: Unhealthy dietary habits highly caloric foods induce metabolic alterations promote the development of inflammatory consequences obesity insulin resistance, which are epidemic conditions leading to diabetes cardiovascular diseases. Describing an effect diet is difficult pursue, owing lack quali-quantitative assessment standardization. The Dietary Inflammatory Index (DII) has been proposed as estimator pro- or anti-inflammatory nutritional components. Higher DII...
Abstract Background The number of carotid plaques independently predicts incident atherosclerotic cardiovascular disease (ACVD). However, performing vascular imaging in apparently healthy subjects is challenging, owing organizational/economical barriers. Plasma proteomics can offer an alternative approach to identify individuals with plaques, at high risk eventually developing ACVD. Methods In this observational study, we studied by Normalized Protein eXpression (NPX; Olink TM ), the plasma...
Abstract Background Subjects affected by genetically proven heterozygous Familial Hypercholesterolemia (FH) present lifelong exposure to high Low Density Lipoprotein Cholesterol ("LDL-C burden") causing premature ACVD. Nevertheless, the diagnosis of FH is still far from being optimal due shortcomings clinical algorithms in detecting this form severe ACVD since early decades life (1) and because a significant proportion comparable LDL-C levels that subjects who are hypercholesterolemic but...
Background and aim: High cholesterol in Low-Density Lipoproteins (LDL-C) is the key target of current pharmacological treatments aimed at reducing atherosclerotic cardiovascular disease (ACVD) risk. Increased Very low-density lipoproteins (“VLDL-C”) an independent predictor ACVD. VLDL-C was previously associated with markers inflammation (for instance C-reactive protein). We now tested relationship between either or LDL-C a large spectrum inflammatory proteins plasma collected from subjects...