A5016916859- Biochemical and Molecular Research
- Metabolism and Genetic Disorders
- Urban Planning and Valuation
- Amino Acid Enzymes and Metabolism
- Cytomegalovirus and herpesvirus research
- HIV/AIDS drug development and treatment
- Adenosine and Purinergic Signaling
- Building Energy and Comfort Optimization
- Diet, Metabolism, and Disease
- Gout, Hyperuricemia, Uric Acid
- Acute Lymphoblastic Leukemia research
- Smart Cities and Technologies
- Chronic Lymphocytic Leukemia Research
- Diverse academic and cultural studies
- Liver Disease Diagnosis and Treatment
- Hormonal and reproductive studies
- BIM and Construction Integration
- Genetic factors in colorectal cancer
- Healthcare and Venom Research
- Architecture and Computational Design
- Folate and B Vitamins Research
- Venomous Animal Envenomation and Studies
- Cancer, Hypoxia, and Metabolism
- Enzyme Structure and Function
- Urban Planning and Landscape Design
University of Milano-Bicocca
2007-2025
Polytechnic University of Turin
2009-2023
University of Iceland
2021
University of Insubria
2018
Politecnico di Milano
2014
University of Siena
2000-2009
Azienda Ospedaliera Universitaria Senese
2009
Karolinska Institutet
1993
University of Bologna
1992
Istituto di Chimica Biomolecolare
1969
Background and purpose: Accurate instance segmentation of teeth in panoramic dental X-rays is a challenging task due to variations tooth morphology overlapping regions. In this study, we propose new algorithm, for instance, the different X-rays. Methods: An model was trained using architecture Mask Region-based Convolutional Neural Network (Mask-RCNN). The data training, validation, testing were taken from Tuft database (1000 radiographs). number predicted label 52 (20 deciduous 32...
In industrial large scale bio-reactions micro-organisms are generally exposed to a variety of environmental stresses, which might be detrimental for growth and productivity. Reactive oxygen species (ROS) play key role among the common stress factors--directly--through incomplete reduction O(2) during respiration, or indirectly--caused by other stressing factors. Vitamin C L-ascorbic acid acts as scavenger ROS, thereby potentially protecting cells from harmful oxidative products. While most...
Leukocyte Adhesion Defects (LADs) are a group of rare autosomal recessive immune disorders characterized by constitutional defects in the process leukocyte migration. Among these, LAD-III is rarest, with only few cases documented scientific literature. It caused mutations FERMT3 gene, impairing integrin function both white blood cells and platelets. Thus, patients exhibit variable degree immunodeficiency along severe bleeding tendency referred to as “Glanzmann-like”, due dysfunctional...
<i>Mucuna pruriens</i> seeds have been widely used against snakebite in traditional medicine. The antivenin property of a water extract was assessed <i>in vivo</i>in mice. serum mice treated with tested for its immunological properties. Two proteins <i>Echis carinatus</i>venom apparent molecular masses 25 and 16 kDa were detected by Western blot analysis carried out using IgG immunized or partially purified protein fractions. By enzymatic in-gel digestion electrospray ionization-mass...
Objective: Resilience is a multidimensional process of adaptation aimed to overcome stressful or traumatic life experiences; only in the last few years it has been considered as personal resource psychosis and schizophrenia. This study assess relationship between intrapersonal interpersonal resilience factors schizophrenia, particularly whether how can improve course psychotic illness. Patients methods: In this observational study, all patients recruited had fulfill following inclusion...
The diagnosis and monitoring of severe combined immunodeficiency disease (SCID) attributable to adenosine deaminase (ADA) deficiency requires measurements ADA, purine nucleoside phosphorylase (PNP), S-adenosyl-L-homocysteine-hydrolase (SAHH) activity deoxyadenosine metabolites. We developed capillary electrophoresis (CE) methods for the detection key diagnostic metabolites evaluation enzyme activities.Deoxyadenosine were separated in 30 mmol/L sodium borate-10 dodecyl sulfate (pH 9.80) at 25...
Abstract The behavior of xanthine oxidase in the jejunal mucosa patients with gout and liver normal subjects during secondary drug‐induced hyperuricemia was studied. Xanthine activity not increased significantly gout, whereas an RNA, hypoxanthine, EA‐TDA, or fructose load caused levels to rise values that were two‐ fourfold higher than those for control group. results indicated previously reported increases who overexcretors, neither primary nor genetically determined but related production enzyme.
Proteomic approach is an effective method to study changes in human plasma proteome. Coagulopathies are commonly encountered victims of viper envenomation which were treated with administration immunoglobulin. Unfortunately, this treatment shows significant risk the patient due anaphylactic reaction. Since Echis carinatus Venom (EV) toxins mainly acts both directly and indirectly on fibrinogen, we planned establish a suitable analysis its beta (FIBB) e gamma (FIBG) chains. This will help us...
Previously, we reported the antisnake venom properties of a Mucuna pruriens seed extract (MPE) and tested its in vivo efficacy against Echis carinatus (EV) short- (1 injection) long-term (three weekly injections) treatments. The aim present study was to investigate plasma proteome changes associated with MPE treatments identify proteins responsible for survival envenomated mice (CHALLENGED mice). Six treatment groups were studied. Three control groups: one saline, short-term treatment. One...
1 The aldol breakdown of l-threonine and l-allothreonine in rat liver is catalyzed by systems localized the soluble fraction homogenate. 2 Evidence presented that two different enzymes, indicated as “threonine aldolase” “allothreonine aldolase”, are involved amino acids
Abstract The effect of a lethal Echis carinatus venom on serum enzyme levels and blood plasma coagulation parameters in rats pretreated with Mucuna pruriens seed aqueous extract MP101UJ (21 mg/kg body wt) 24 h 3 wk before i.p injection (0.50 rat) injected alone was investigated. parameter were measured 4 after administration. results showed that the increased enzymes lactate dehydrogenase (LDH), glutamic pyruvic transaminase (SGPT), creatinine kinase (CK) changed D‐Dimer Quick due to...
We have elaborated a kinetic method which allows us to evaluate whether Michaelis-Menten-type enzyme acting on two different substrates has one or active sites. This been used with the rat liver L-threonine dehydratase, catalyzes dehydrative deamination of both serine and threonine. The experimental data can be fitted theoretical plot obtained for case single site.
Using a combination of chromatographic and NMR techniques, the presence D-chiro-inositol its two galacto-derivatives is demonstrated in Mucuna pruriens seeds. The quantities detected explain well-established antiglycaemic effect