A5069909747- Intestinal and Peritoneal Adhesions
- Hernia repair and management
- Thyroid and Parathyroid Surgery
- Reproductive Biology and Fertility
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nitric Oxide and Endothelin Effects
- Ovarian function and disorders
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Intraperitoneal and Appendiceal Malignancies
- Vitamin C and Antioxidants Research
- Cancer, Hypoxia, and Metabolism
- Surgical Sutures and Adhesives
- Uterine Myomas and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammatory mediators and NSAID effects
- Sperm and Testicular Function
- Vitamin K Research Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hemostasis and retained surgical items
- Ovarian cancer diagnosis and treatment
- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Dermatologic Treatments and Research
- Vanadium and Halogenation Chemistry
Wayne State University
2016-2025
The Barbara Ann Karmanos Cancer Institute
2013-2025
University of Jordan
2011-2025
Al-Azhar University
2017
Wayne State College
2013
Minia University
2011
Meharry Medical College
2011
University of Tennessee Health Science Center
2010
Woodward (United States)
2005-2009
Hutzel Women's Hospital
2001-2008
Injury to the peritoneum during surgery is followed by a healing process that frequently results in attachment of adjacent organs fibrous mass, referred commonly as adhesions. Because injuries are inevitable, it imperative we understand mechanisms adhesion formation prevent its occurrence. This requires thorough understanding molecular sequence injured and development tissue. Recent data show fibroblasts from may play critical role tissues. Therefore, identifying changes gene expression...
Keloids are the result of a dysregulated wound-healing process and characterized by formation excess scar tissue that proliferates beyond boundaries inciting wound. In this study, we investigated expression key proteins involved in regulating apoptosis keloids. Twenty archival paraffin-embedded keloid samples were randomly selected for an immunoperoxidase assay with antibodies against fas, p53, bcl-2, bcl-x using target antigen-retrieval technique. Apoptosis was assessed keloids normal skin...
To determine the efficacy of 585-nm flashlamp-pumped pulsed-dye laser and silicone gel sheeting in treatment hypertrophic scars lighter- darker-skinned patients.Prospective, single-blind, randomized, internally controlled, comparison investigation.Large academic dermatology department.Twenty patients with (19 completed treatments 18 treatments).Clinical measurements included scar blood flow, elasticity, volume. Patients' subjective complaints pruritus, pain, burning were also monitored....
Overexpression and accumulation of extracellular matrix is central to peritoneal adhesion formation following surgically induced tissue trauma. Transforming growth factor‐β1 hypoxia have been implicated in fibrosis postoperative formation. To extend this observation we examined whether transforming and/or regulate the expression type I III collagen human mesothelial cells. Cultured cells were maintained under (2% oxygen), or treated with (1 ng/ml) a combination factor‐β1. Total cellular RNA...
Glandular kallikrein (EC 3.4.21.8) belongs to a subgroup of serine proteases coded by multigene family. A kininogenase resembling glandular has been identified in vascular tissue; however, it is not clear whether synthesized tissue or taken up from plasma. To determine the potential for synthesis tissues, we tested messenger RNA (mRNA) present rat arteries and veins. Poly(A+) was isolated pools veins (n = 3, 30 rats each). kidney liver used as positive negative control, respectively. As...
This study explores the role of titin, a giant muscle protein, in progression epithelial ovarian cancer (EOC). We examined titin levels tissues and sera from EOC patients across stages I-IV chemoresistant cells. Tissue samples underwent immunohistochemistry, serum were measured using ELISA. Quantitative real-time PCR analyzed mRNA cell lines, including chemosensitive, chemoresistant, normal Notably, elevated detected 90.9% stage I compared to only 14.3% III IV tissues. Serum consistently...
Keloids are the result of a dysregulated wound healing process. They characterized by formation excess scar tissue that proliferates beyond boundaries original wound. Somatic mutations p53 have been implicated as causal events in up to 50% all human malignancies. In addition, has shown play an important role controlling cell proliferation and apoptosis. We hypothesize can lead hyperproliferative state keloid formation.To detect DNA tissues cultured fibroblasts from skin lesions 7 patients...