A5058108243- Advanced Glycation End Products research
- Natural Antidiabetic Agents Studies
- SARS-CoV-2 and COVID-19 Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Virus-based gene therapy research
- Animal Virus Infections Studies
- vaccines and immunoinformatics approaches
- Alzheimer's disease research and treatments
- Diabetes and associated disorders
- Epigenetics and DNA Methylation
- Diet, Metabolism, and Disease
- Computational Drug Discovery Methods
- Heavy Metal Exposure and Toxicity
- Diverse Scientific Research Studies
- Long-Term Effects of COVID-19
- Neurological Disease Mechanisms and Treatments
- Nanoparticles: synthesis and applications
- Atherosclerosis and Cardiovascular Diseases
- Drug Transport and Resistance Mechanisms
- Per- and polyfluoroalkyl substances research
- Tryptophan and brain disorders
- Flavonoids in Medical Research
- Phytochemicals and Antioxidant Activities
- Autophagy in Disease and Therapy
- Pluripotent Stem Cells Research
Long Island University
2024-2025
Uttaranchal University
2022-2025
Jamia Millia Islamia
2024
Department of Biotechnology
2024
Integral University
2017-2024
Bovine coronavirus (BCoV) exhibits dual tissue tropism, infecting both the respiratory and enteric tracts of cattle. Viral entry into host cells requires a coordinated interaction between viral proteins. However, specific cellular receptors co-receptors facilitating BCoV remain poorly understood. Similarly, roles proteases such as Furin, TMPRSS2, Cathepsin-L (CTS-L), known to assist in replication other coronaviruses, have not been extensively explored for BCoV. This study aims identify...
Hundreds of millions people around the globe are afflicted by diabetes mellitus. The alteration in glucose fixation process might result into hyperglycaemia and could affect circulating plasma proteins to undergo nonenzymatic glycation reaction. If it is unchecked, may lead with increase advanced end products (AGEs). Therefore, present study was designed inhibit using natural antioxidant "ellagic acid" (EA). In this study, we explored antidiabetes antiglycation potential EA both vitro (EA at...
Glycation is vital in terms of its damaging effect on macromolecules resulting the formation end products, which are highly reactive and cross-linked irreversible structures, known as advanced glycation products (AGEs). The continuous accumulation AGEs associated with severe diabetes ailments. Saccharides their reducing ends can glycate amino acid side chains proteins, among them glucose well-known for potent glycating capability. However, other sugars be more agents than glucose. D-ribose a...
Methylglyoxal (MG) is a precursor for advanced glycation end-products (AGEs), which have significant role in diabetes. The present study designed to probe the immunological response of native and glycated low-density lipoprotein (LDL) experimental animals. second part this glycoxidative lesion detection lipoproteins diabetes subjects with varying disease duration. neo-epitopes attributed glycation-induced LDL DM patients' plasma were, analyzed by binding MG-modified immunized animal sera...
Free radicals exist as unstable and highly reactive substances, occurring both in outside the body. are labeled electron-hungry molecules formed from metabolism endogenous burning of oxygen. They transported cells, upsetting arrangement instigating cellular injury. Hydroxyl radical (•OH) is one free radicals, which damages biomolecules its close vicinity.In present study, DNA was modified by hydroxyl generated via Fenton reaction. The •OH-oxidized/-modified (Ox-DNA) characterized UV-visible...
Bovine coronavirus (BCoV) is one of the most common pathogens affecting cattle all ages. BCoV possesses multiple tissue tropism in cattle, particularly respiratory and enteric tracts affected animals. Viral entry a crucial step replication cycle viruses, including BCoV. The process viral requires orchestration between several proteins from virus host side. spike glycoproteins contributed substantially to other infections molecular pathogenesis coronaviruses, Meanwhile, among corona-viruses,...
BCoV is one of the significant causes enteritis in young calves; it may also be responsible for many respiratory outbreaks calves. participates development bovine disease complex association with other bacterial pathogens. Our study aimed (1) to map immunogenic epitopes (B and T cells) within major structural proteins. These are believed induce a robust immune response through interaction histocompatibility (MHC class II) molecules (2) design some novel multiepitope-based vaccines.
Abstract Biosynthetic procedure is one of the best alternatives, inexpensive and ecologically sound for synthesis titanium dioxide (TiO 2 ) nanoparticles using a methanolic extract medicinal plant. The main prospect this study was to investigate antiglycation activity TiO (TNP) prepared by ethanolic leaf Coleus scutellarioides . In study, biosynthesized TNP characterized with UV‐Visible spectroscopy, X‐ray diffraction, Fourier transform infrared spectroscopy scanning electron microscope....
Glycation of immunoglobulin-G (IgG) molecules with monosaccharides may cause significant structural disability, thus resulting in their loss function. The accumulation AGEs formed from glycation plays an important role the aliments associated metabolic diseases. Therefore, excess sugar plasma interferes functioning IgG and contribute to a wide range diabetes-associated complications. long-term formation these heterogeneous accumulate affect proteins, especially long-lived proteins. In this...
Apolipoprotein A-I (apoA-I) protects against atherosclerosis and participates in the removal of excess cellular cholesterol from peripheral organs. Several naturally occurring apoA-I mutations are associated with familial systemic amyloidosis, deposition amyloid aggregates organs, resulting multiple organ failure. Systematic studies on variants needed to delineate their roles involvement pathogenesis.We performed a comparative structure-function analysis five wild-type protein. Circular...
This investigation explores the successful synthesis and comprehensive characterization of Citrus sinensis seed-mediated gold nanoparticles designated as C-AuNPs. Visual confirmation was achieved through a distinct ruby red color change in reaction mixture, followed by UV-Visible spectroscopy, which revealed characteristic peak absorbance at 522 nm due to Surface Plasmon Resonance (SPR) phenomenon associated with nanoparticles. Transmission Electron Microscopy (TEM) analysis demonstrated...