A5000815825- Genomics and Chromatin Dynamics
- Estrogen and related hormone effects
- Microbial bioremediation and biosurfactants
- Epigenetics and DNA Methylation
- Heavy metals in environment
- Lung Cancer Treatments and Mutations
- Mercury impact and mitigation studies
- Nanoparticles: synthesis and applications
- Cancer-related gene regulation
- Lung Cancer Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Microbial Community Ecology and Physiology
- Pleural and Pulmonary Diseases
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Developmental Biology and Gene Regulation
- Connective tissue disorders research
- Medicinal Plants and Neuroprotection
- Seed Germination and Physiology
- Toxic Organic Pollutants Impact
- Diverse Scientific Research Studies
- Natural Antidiabetic Agents Studies
- Electrokinetic Soil Remediation Techniques
- Venous Thromboembolism Diagnosis and Management
- Histone Deacetylase Inhibitors Research
University Hospitals of North Midlands NHS Trust
2016-2025
University of Leicester
2024
Balochistan University of Information Technology, Engineering and Management Sciences
2024
COMSATS University Islamabad
2022-2023
Abbottabad University of Science and Technology
2023
Royal Stoke University Hospital
2011-2023
Abbott (Germany)
2023
Sustainability Institute
2023
Glocal University
2021-2022
University of Sialkot
2021-2022
Expansion of the intronic CTG18.1 triplet repeat locus within TCF4 contributes significant risk to development Fuchs' endothelial corneal dystrophy (FECD) in Eurasian populations, but mechanisms by which expanded repeats result degeneration endothelium have been hitherto unknown. The purpose this study was examine FECD samples for presence RNA nuclear foci, hallmark toxic RNA, as well evidence haploinsufficiency TCF4.Using fluorescence situ hybridization, we examined foci containing CUG...
To test the association between CTG18.1 trinucleotide repeat expansion of TCF4 gene and Fuchs' endothelial corneal dystrophy (FECD) in a Chinese population.The polymorphism was genotyped using short tandem triplet primed polymerase chain reaction assays 57 subjects with FECD 121 controls. Statistical expanded allele 18 single nucleotide polymorphisms (SNPs) across evaluated. investigate linkage disequilibrium structure region, haplotype analysis performed on our study compared genotyping...
Wheat is regarded as a main staple crop in Pakistan because its contribution to the daily diet of common man 60%. Late sowing wheat not only reduces yield but also affects efficiency other production factors it possible absolutely avoid late sowing. Moringa leaf extract (MLE), exogenously applied either through seed or plant foliage, known boost field crops productivity under both normal and unfavorable conditions. A study was conducted evaluate growth enhancing potential MLE alone...
HOXC10 is a critical player in the development of spinal cord, formation neurons, and associated with human leukemia. We found that overexpressed breast cancer transcriptionally regulated by estrogen (17β-estradiol, E 2 ). The promoter contains several response elements (ERE1–7, half-sites). A luciferase-based reporter assay showed ERE1 ERE6 are responsive. ERα ERβ play roles -mediated activation . Knockdown downregulated -induced expression. bind to regions an -dependent manner....
HOXB9 is a homeobox-containing gene and critical for the development of mammary gland sternum. also regulated by estrogen angiogenesis. We investigated biochemical roles its homeodomain in cell-cycle progression tumorigenesis. Our studies demonstrated that overexpressed breast cancer tissue. overexpression stimulated 3D formation soft agar assay. binds to promoters various tumor growth angiogenic factors regulates their expression. The plays crucial transcriptional regulation colony...
Soil salinity imposes an unprecedented risk to the soil fertility and availability of plant nutrients. The present proposal is designed address effect salt stress on photosynthetic apparatus maize including chlorophyll a fluorescence how silicon nutrition helps overcome this issue. In sand culture experiment, two cultivars were sown in small pots with levels (0 2 mM H2SiO3) 60 NaCl). Salinity reduced dry matter yield potassium (K) concentration both also induced inefficient working...
Petroleum contamination and its remediation via plant-based solutions have got increasing attention by environmental scientists engineers. In the current study, physiological growth responses of two diesel-tolerant plant species (tolerance limit: 1500-2000 mg/kg), Italian ryegrass (Lolium multiflorum) Birdsfoot trefoil (Lotus corniculatus), been investigated in vegetable oil- diesel oil-amended soils. A long-term (147-day) greenhouse pot experiment was conducted to differentiate main focus...
Insulin is a key regulator of metabolism, but it also confers protective effects on the cardiovascular system. Here, we analyze mechanism by which insulin stabilizes endothelial barrier function.Insulin reduced basal and antagonized tumor necrosis factor-alpha-induced macromolecule permeability rat coronary microvascular monolayers. It abolished reperfusion-induced vascular leakage in isolated-perfused hearts. induced dephosphorylation regulatory myosin light chains, as well translocation...
HOXC13 is a homeobox containing gene that plays crucial roles in hair development and origin of replication. Herein, we investigated the biochemical functions explored its potential tumor cell viability. We have designed phosphorothioate based antisense-oligonucleotide specifically knockdown cultured cells. Cell viability cytotoxicity assays demonstrated essential for growth Antisense-mediated affected induced apoptosis regulates expression cyclins antisense-mediated resulted cycle arrest...
Abstract Hypoxia‐inducible factor‐1alpha (HIF‐1α) is aberrantly upregulated in tumors and implicated angiogenesis, metastasis, drug resistance. Therefore, developing treatments that target HIF‐1α may be a viable therapeutic approach. In Traditional Chinese Medicine (TCM), Scutellaria baicalensis (SB) used for the treatment of cancer but anti‐cancer mechanisms are not known. We examined effects SB on expression ovarian (OC) cell lines grown under normoxic hypoxic conditions. attenuated lines....
HOXC13, a homeobox‐containing gene, is involved in hair development and human leukemia. The regulatory mechanism that drives HOXC13 expression mostly unknown. Our studies have demonstrated transcriptionally activated by the steroid hormone estrogen (17β‐estradiol; E2). promoter contains several estrogen‐response elements (EREs), including ERE1 ERE2, which are close to transcription start site, associated with E2‐mediated activation of HOXC13. Knockdown receptors (ERs) ERα ERβ suppressed...
Homeobox gene HOXB9 is a critical player in development of mammary gland and sternum regulation renin which closely linked with blood pressure control. Our studies demonstrated that transcriptionally regulated by estrogen (E2). promoter contains several estrogen-response elements (ERE). Reporter assay based experiments EREs are responsive. Estrogen receptors ERα ERβ essential for E2-mediated transcriptional activation HOXB9. Chromatin immunoprecipitation ERs bind to as function E2....