A5101974284- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Telomeres, Telomerase, and Senescence
- Cancer-related gene regulation
- Bone Metabolism and Diseases
- Fungal and yeast genetics research
- Protein Tyrosine Phosphatases
- Membrane Separation Technologies
- Biomarkers in Disease Mechanisms
- Chromosomal and Genetic Variations
- Circular RNAs in diseases
- Genetic Neurodegenerative Diseases
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Solar-Powered Water Purification Methods
- Testicular diseases and treatments
- Membrane-based Ion Separation Techniques
- Crystallization and Solubility Studies
- MicroRNA in disease regulation
- Plant Molecular Biology Research
- Toxoplasma gondii Research Studies
- Kruppel-like factors research
- Genomics and Phylogenetic Studies
- Crystallography and molecular interactions
Center for Excellence in Molecular Cell Science
2020-2024
University of Chinese Academy of Sciences
2020-2024
Zhejiang Chinese Medical University
2023
Chinese Academy of Sciences
2022
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
2015-2021
Van Andel Institute
2013-2017
Norrin is a cysteine-rich growth factor that required for angiogenesis in the eye, ear, brain, and female reproductive organs. It functions as an atypical Wnt ligand by specifically binding to Frizzled 4 (Fz4) receptor. Here we report crystal structure of Norrin, which reveals unique dimeric with each monomer adopting conserved cystine knot fold. Functional studies demonstrate novel dimer interface Fz4 activation. Furthermore, contains separate sites coreceptor Lrp5 (low-density...
Rice D53 repression motif links two sites of TPL corepressors to mediate oligomerization and nucleosome association.
In eukaryotic organisms, genetic information is usually carried on multiple chromosomes. Whether and how the number configuration of chromosomes affect organismal fitness speciation remain unclear. Here, we have successfully established several single-chromosome fission yeast Schizosaccharomyces pombe strains, in which three natural been fused into one giant chromosome different orders. Chromosome fusions accompanied by deletions telomeres centromeres result loss chromosomal interactions a...
Malignant transformation arising in mature cystic teratoma (MT-MCT) is a rare neoplasm of the ovary. Herein, we aimed to evaluate clinicopathological features and treatment outcome Han Chinese women with MT-MCT.In this retrospective study, clinical data patients who had been surgically treated from January 2000 November 2019 whom diagnosis MCT was confirmed based on pathology were included. Fourteen MT-MCT total 569 cases (2.46% incidence) reviewed.The mean age 51.3 (range, 31-71) years,...
Telomeres define the natural ends of eukaryotic chromosomes and are crucial for chromosomal stability. The budding yeast Cdc13, Stn1 Ten1 proteins form a heterotrimeric complex, inactivation any its subunits leads to uniformly lethal phenotype due telomere deprotection. Although seem belong an epistasis group, it remains unclear whether they function differently in protection. Here, we employed single-linear-chromosome SY14, surprisingly found that deletion CDC13 erosion intrachromosome...
A nucleosome contains two copies of each histone H2A, H2B, H3 and H4. Histone K4me0 K36me3 are key chromatin marks for de novo DNA methylation catalyzed by methyltransferases in mammals. However, it remains unclear whether on both sister H3s regulate independently or cooperatively. Here, taking advantage the bivalent system yeast, we examined contributions K4 K36 to genomic ectopically co-expressed murine Dnmt3a Dnmt3L. The results show that lack one tail, respective a dramatic reduction...