A5037379472- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- Osteoarthritis Treatment and Mechanisms
- Spectroscopy Techniques in Biomedical and Chemical Research
- Periodontal Regeneration and Treatments
- Dental Implant Techniques and Outcomes
- Anatomy and Medical Technology
- Orthopedic Infections and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Bone fractures and treatments
- Hip and Femur Fractures
- Knee injuries and reconstruction techniques
- Infrared Thermography in Medicine
- 3D Printing in Biomedical Research
- Artificial Intelligence in Healthcare and Education
- Spectroscopy and Chemometric Analyses
- Spaceflight effects on biology
- Mechanical Circulatory Support Devices
- Orthopedic Surgery and Rehabilitation
- Cellular Mechanics and Interactions
- Surgical Sutures and Adhesives
- Musculoskeletal Disorders and Rehabilitation
- Silk-based biomaterials and applications
- Mesenchymal stem cell research
Istituto Ortopedico Rizzoli
2020-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2020
Bone grafting is one of the most used surgical techniques to favor bone regeneration and repair in orthopedic procedures. Despite autografting continuing be considered gold standard, allogeneic tissues remain a viable alternative albeit last decades, only few studies have been carried out translate enhanced grafts into clinical solutions. In this vitro study, cortical samples were coated with copper-doped bioactive glass 45S5 (Cu-BG) by means pulsed-laser deposition technique combine...
Bone grafts and bone-based materials are widely used in orthopedic surgery. However, the selection of bone type to be is more focused on biological properties sources than physico-chemical ones. Moreover, although biogenic increasingly for deposition biomimetic nanostructured coatings, influence specific precursors coating’s morphology composition has not yet been explored. Therefore, order fill this gap, we provided a detailed characterization mineral phase most allografts, xenografts...
Abstract In this study, Brillouin and Raman micro-Spectroscopy (BRamS) Machine Learning were used to set-up a new diagnostic tool for Osteoarthritis (OA), potentially extendible other musculoskeletal diseases. OA is degenerative pathology, causing the onset of chronic pain due cartilage disruption. Despite this, it often diagnosed late radiological assessment during routine examination may fail recognize threshold beyond which pharmacological treatment no longer sufficient prosthetic...
Complex deformities of lower limbs are frequent in children with genetic or metabolic skeletal disorders. Early correction is frequently required, but it technically difficult and burdened by complications recurrence. Herein, we described the case a 7-year-old girl affected severe bilateral genu varum due to spondyloepiphyseal dysplasia. The patient was treated patient-specific osteotomies customized structural wedge allograft using Virtual Surgical Planning (VSP) 3D-printed instrumentation...
The purpose of the current investigation was to evaluate clinical success horizontal ridge augmentation in severely atrophic maxilla (Cawood and Howell class IV) using freeze-dried custom made bone harvested from tibial hemiplateau cadaver donors, analyze marginal level gain prior dental implant placement at nine months subsequent grafting before prosthetic rehabilitation. A 52-year-old woman received grafts. patient underwent CT scans two weeks after surgery for graft volume density...
Abstract Background A first-year interim analysis of this two-year study suggested that intra-articular injections highly purified, natural-origin polynucleotides and hyaluronic acid (HA) as a fixed combination (PNHA) might improve knee function joint pain more effectively than HA alone in patients with osteoarthritis (OA). The purpose the second-year herein described was to verify whether outcomes persist over whole period. Methods Randomised, double-blind, HA-controlled clinical trial 100...
Background: The aim of the present investigation was to evaluate clinical success horizontal ridge augmentation in severely atrophic maxilla (Cawood and Howell class IV) using freeze-dried custom made bone harvested from cadaver donors tibial hemiplateau analyze marginal level gain prior dental implants placement at 9 months after grafting before prosthetic rehabilitation. Methods: A 52-year-old woman received grafts. Patient underwent CT scans 2 weeks surgery for graft volume density...
Human bone is a specialized tissue with unique material properties, providing mechanical support and resistance to the skeleton simultaneously assuring capability of adaptation remodelling. Knowing properties such structure down micro-scale utmost importance, not only for design effective biomimetic materials but also be able detect pathological alterations in as micro-fractures or abnormal The Brillouin Raman micro-spectroscopic (BRmS) approach has potential become first-choice technique,...
(1) Background: Virtual reality and 3D printing are transforming orthopedic surgery by enabling personalized three-dimensional (3D) models for surgical planning Patient-Specific Instruments (PSIs). Hospitals establishing in-house centers to reduce costs improve patient care. Pediatric also benefits from these technologies, enhancing the precision personalization of treatments. This study presents preliminary results an In-Office Printing Point Care (PoC), outlining considerations challenges...
Abstract Background To date, hip arthroplasty is one of the most commonly performed surgical procedures, with growing worldwide demand. In recent decades, major progress made in terms technique, biomechanics, and tribology knowledge has contributed to improve medical functional management patient. This study aims assess if application a fast track protocol, consisting preoperative educational intervention, adequate postoperative pain control, intensive rehabilitation reduces length stay...
The use of massive bone allografts after the resection tumours is still a challenging process. However, to overcome some issues related processing procedures and guarantee best three-dimensional matching between donor recipient, tissue banks have developed virtual database based on scanning available for using their 3D shape during surgical planning (VSP) procedures. To promote future VSP bone-shaping protocols useful machining applications within cleanroom environment, in our work, we...
Brillouin and Raman microspectroscopy (BRamS) is a scattering technique that simultaneously assesses the mechanical chemical properties of tissues with micrometric resolution. It has gained increasing attention in biomedical field over last decade been successfully used for both single-cell studies whole-tissue characterization under physiological pathological conditions. In addition, it non-destructive, non-contact, does not require labeling, offering potential future vivo applications. The...
Abstract Human decellularized bone fragments are commonly used in clinics to perform allograft surgeries. To reduce the immunological response recipient and ensure their safety, these underwent decellularization, a procedure that greatly reduces osteogenicity (the ability induce differentiation into osteoblast). In this work, by introduction of an ultrasonication step fragment human bone, size distribution resulting demineralize particles can be controlled, tuning osteogenic potential. The...
One of the greatest challenges hip revision surgery is need to restore extensive bone loss by creating a stable reconstruction with long-term durability. The present observational, investigator-initiated prospective study was carried out evaluate clinical and radiological results use commercial biomimetic collagen-hydroxyapatite composite biomaterial (RegenOss) applied in surgery. Thirty-three patients who underwent were included this study, 29 received up 2 years follow-up. acetabulum...
Extracorporeal membrane oxygenation (ECMO) is an invasive medical technique used to provide life support in persons with insufficient cardiac and respiratory functionalities, or preserve, postmortem, organ function addressing organ/tissue transplant. Although a lot of information available about organs their entirety, the safety effectiveness allogeneic tissues collected from ECMO donors have not been fully elucidated. In this preliminary study, samples tibial peroneal human tendons were...
Adipose tissue is an attractive source of stem cells due to its wide availability. They contribute the stromal vascular fraction (SVF), which composed pre-adipocytes, tissue-progenitors, and pericytes, among others. Because direct use in medical applications increasing worldwide, new quality control systems are required. We investigated ability Non-Equilibrium Earth Gravity Assisted Dynamic Fractionation (NEEGA-DF) method analyze separate based solely on their physical characteristics,...
Bone Allografts In article 2300635, Alessio Bucciarelli, Devid Maniglio, Francesco Grassi, and co-workers develop a method to generate microparticles from human cortical decellularized bone based on an ultrasonication approach. Both particle diameter Alkaline Phosphatase activity are tunable according the parameters. By evaluating correlations among different outcomes, inverse linear correlation between size biological properties found.
Abstract BackgroundTo date, the hip arthroplasty is one of most commonly performed surgical procedures, with a growing worldwide demand. In recent decades, major progress made in terms technique, biomechanics and tribology knowledge have contributed to improve medical functional management patient. This study aims assess if application fast track protocol, consisting pre-operative educational intervention, adequate post-operative pain control intensive rehabilitation reduces length stay...
The optimization of advanced in vitro models is essential for the development alternative methods. study osteochondral regeneration still has numerous limitations and wide scope exploration.