A5101884404- Alzheimer's disease research and treatments
- Advanced Fiber Laser Technologies
- Photonic Crystal and Fiber Optics
- Software Engineering Techniques and Practices
- Luminescence and Fluorescent Materials
- Prostate Cancer Diagnosis and Treatment
- Educational Reforms and Innovations
- Multisensory perception and integration
- Berberine and alkaloids research
- Sirtuins and Resveratrol in Medicine
- Alkaloids: synthesis and pharmacology
- Humor Studies and Applications
- Biochemical effects in animals
- Ziziphus Jujuba Studies and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cellular transport and secretion
- Natural Compound Pharmacology Studies
- Bladder and Urothelial Cancer Treatments
- Diamond and Carbon-based Materials Research
- Endoplasmic Reticulum Stress and Disease
- Medical Research and Treatments
- Colorectal Cancer Screening and Detection
- Cancer Immunotherapy and Biomarkers
- Emotion and Mood Recognition
- Advanced Fiber Optic Sensors
Fujian Medical University
2019-2025
Fujian Provincial Hospital
2025
Fuzhou University
2025
Zhejiang University
2022-2024
First Affiliated Hospital of Dalian Medical University
2024
Dalian Medical University
2024
First Affiliated Hospital of Fujian Medical University
2019-2023
Zhejiang University of Technology
2023
Huazhong University of Science and Technology
2014-2022
Wuhan National Laboratory for Optoelectronics
2022
Abstract Being a new class of two dimensional (2D) metal carbides, borides, and nitrides, MXenes comprise one the largest families 2D nanomaterials that provide huge possibilities in photonics, electronics, energy, Particularly, are discovered recently as alternatives to conventional saturable absorbers (SAs), such carbon nanotube graphene, which used for short laser pulse generation. The high absorption, astounding modulation depth, flexible bandgap tunability, electron density near Fermi...
<title>Abstract</title> Background Prostate cancer (PCa) is the second most common male cancer. Despite undergoing radical prostatectomy (RP), 20–30% of patients experience recurrence within 5 years. Unsupervised learning method based on radiomics features has proved its efficiency for predicting in with breast and lung In this study, we sought to identify subgroups PCa after RP using an unsupervised clustering clinical MRI features, further evaluate prognostic value 5-year progression-free...
Berberine is a primary component of the most functional extracts Coptidis rhizome used in traditional Chinese medicine for centuries. Recent reports indicate that has potential to prevent and treat Alzheimer's disease (AD). The previous studies reported Calyculin A (CA) impaired axonal transport neuroblastoma-2a (N2a) cells. attenuated tau hyperphosphorylation cytotoxicity induced by CA. Our study aimed at investigating effects on impairment CA N2a results showed could protect cell from...
Abstract Context Patients with type 2 diabetes mellitus (T2DM) are at significantly increased risk of Alzheimer disease (AD). However, no biomarkers available for early identification patients T2DM cognitive impairment (T2DM-CI). Mitochondrial dysfunction is linked to AD. Silent Information Regulator 1 (SIRT1), which responsible regulating mitochondrial biogenesis, and its related miRNAs were also altered in Objective This study aimed determine whether function peripheral blood mononuclear...
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD). It shown that apoE4 preferentially undergoes aberrant cleavage in neurons, yielding neurotoxic C-terminal-truncated fragment. Endoplasmic reticulum (ER) stress has also been known to be involved pathogenesis of AD. However, little about contribution ER neurotoxicity In present study, we established neuron-specific expression human apoE4(1-272) fragment transgenic mice and transfected neuroblastoma N2a...
The present study explored the antidepressant-like activity of α-mangostin (α-MG) and possible mechanism in this process tail suspension test (TST) mice. results revealed that α-MG (5 mg/kg, i.p.) exhibited markedly activity, which could be reversed by pretreatment with haloperidol (a non-selective D2 receptor antagonist), bicuculline competitive GABA p-chlorophenylalanine (an inhibitor 5-HT synthesis). Meanwhile, also effectively increased brain DA, levels mice exposed to TST, indicating...
aDepartment of General Surgery, The First Affiliated Hospital Dalian Medical University, 116000, China bDepartment Cardiology, Second 116021, Liaoning, cDepartment Orthopaedics, 116011, Zhen Wang, Guolin Zhang These authors have contributed equally to this work. Sponsorships or competing interests that may be relevant content are disclosed at the end article. Published online ■ *Corresponding Author Address: . E-mail address: [email protected] (X. Liu). University CHINA. (G. Tan). This is an...
As a foundational model, SAM has significantly influenced multiple fields within computer vision, and its upgraded version, 2, enhances capabilities in video segmentation, poised to make substantial impact once again. While SAMs (SAM 2) have demonstrated excellent performance segmenting context-independent concepts like people, cars, roads, they overlook more challenging context-dependent (CD) concepts, such as visual saliency, camouflage, product defects, medical lesions. CD rely heavily on...
Abstract Traffic congestion can lead to negative driving emotions, significantly increasing the likelihood of traffic accidents. Reducing emotions as a means mitigate speeding, reckless overtaking, and aggressive behaviors is viable approach. Among potential methods, affective speech has been considered one most promising. However, research on humor-based interventions in context scarce, utilization electroencephalogram (EEG) signals for emotion detection humorous audio studies remains...