A5023267851- Microtubule and mitosis dynamics
- 3D Printing in Biomedical Research
- Angiogenesis and VEGF in Cancer
- Nanoparticle-Based Drug Delivery
- Bioinformatics and Genomic Networks
- Cell Image Analysis Techniques
- Radiopharmaceutical Chemistry and Applications
- Bone health and treatments
- Gallbladder and Bile Duct Disorders
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Protein Kinase Regulation and GTPase Signaling
- Cancer Treatment and Pharmacology
- Venomous Animal Envenomation and Studies
- Platelet Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Axon Guidance and Neuronal Signaling
- Cellular Mechanics and Interactions
- Pediatric Hepatobiliary Diseases and Treatments
- Renin-Angiotensin System Studies
Humanitas Mater Domini
2023-2025
Humanitas University
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Université Sorbonne Paris Nord
2010-2023
Hôpital Lariboisière
2023
Université Paris Cité
2003-2019
Inserm
2004-2019
Sorbonne Paris Cité
2013-2019
Délégation Paris 7
2016-2019
Azienda Ospedaliera Pugliese Ciaccio
2016
Negative regulation of mitogenic pathways is a fundamental process that remains poorly characterized. The angiotensin II AT2 receptor rare example 7-transmembrane domain negatively cross-talks with tyrosine kinases to inhibit cell growth. In the present study, we report molecular cloning novel protein, ATIP1 (AT2-interacting protein), which interacts C-terminal tail receptor, but not those other receptors such as AT1, bradykinin BK2, and adrenergic β2 receptor. defines family at least four...
Therapeutic induction of angiogenesis is a potential treatment for chronic ischemia. Heparan sulfate proteoglycans are known to play an important role by their interactions with proangiogenic growth factors such as vascular endothelial factor (VEGF). Low molecular weight fucoidan (LMWF), sulfated polysaccharide from brown seaweeds that mimic some biological activities heparin, has been shown recently promote revascularization in rat critical hindlimb In this report, we first used cultured...
Breast cancer metastasis is a leading cause of death by malignancy in women worldwide. Efforts are being made to further characterize the rate-limiting steps metastasis, i.e. extravasation circulating tumor cells and colonization secondary organs. In this study, we investigated whether angiotensin II, major vasoactive peptide both produced locally released bloodstream, may trigger activating signals that contribute cell metastasis. We used an experimental vivo model which bioluminescent...
We describe an innovative multimodal system, which combines magnetic targeting of therapeutic agents with both resonance and fluorescence imaging into one system. This new nanoplatform consists superparamagnetic γFe2O3 nanoparticles, used clinically as MRI contrast agent, conjugated to molecules the hydroxylmethylene bisphosphonate family (HMBPs): alendronate amine function terminal group. In vitro tests breast cancer cells show that γFe2O3@alendronate hybrid nanomaterial reduces cell...
Metastasis, a fatal complication of breast cancer, does not fully benefit from available therapies. In this study, we investigated whether ATIP3, the major product 8p22 MTUS1 gene, may be novel biomarker and therapeutic target for metastatic tumors. We show that ATIP3 is prognostic marker overall survival among patients with cancer. Notably, tumors, low levels associate decreased patients. By using well-defined experimental mouse model cancer metastasis, expression delays time-course...
HER2-overexpressing metastatic breast cancers are challenging practice in oncology when they become resistant to anti-HER2 therapies such as trastuzumab. In these clinical situations, HER2-overexpression persists localizations, and can thus be used for active targeting using innovative therapeutic approaches. Functionalized gold nanoparticles with antibody stimulated by near-infrared light induce hyperthermia.Here, hybrid nanoshells were engineered photothermal therapy overcome trastuzumab...
Venoms are a rich source of bioactive compounds, and among them is leberagin-C (Leb-C), disintegrin-like protein derived from the venom Macrovipera lebetina transmediterrannea snakes. Leb-C has shown promising inhibitory effects on platelet aggregation. Previous studies have demonstrated that this SECD specifically targets α5β1, αvβ3, αvβ6 integrins through mimic mechanism RGD disintegrins. In our current study, we focused exploring potential metastatic breast cancer. Our findings revealed...
Introduction The poor efficacy of various anti-cancer treatments against metastatic cells has focused attention on the role tumor microenvironment in cancer progression. To understand contribution extracellular matrix (ECM) environment to this phenomenon, we isolated ECM surrogate invading cell populations from MDA-MB-231 breast and studied their genotype malignant phenotype. Methods We invasive subpopulations (INV) non (REF) using a 2D-Matrigel assay, basal membrane passage. INV REF were...
Vascular endothelial growth factor (VEGF) is a multifunctional cytokine that has important roles in angiogenesis. Our knowledge of the significance VEGF isoforms human cancer remains incomplete.Bioluminescence imaging and transcriptomic analysis were used to study colonisation capacity breast cells MDA-MB-231 controlling or overexpressing VEGF165 VEGF189 isoform (named cV-B, V165-B V189-B, respectively) nude mice.When injected into bloodstream, V189-B induced less metastasis lungs bone than...
Background Although there was growing evidence in the potential use of Bisphosphonates (BPs) cancer therapy, their strong osseous affinities that contrast poor soft tissue uptake limited use. Here, we developed a new strategy to overcome BPs hydrophilicity by masking phosphonic acid through organic protecting groups and introducing hydrophobic functions side chain. Methodology/Principal Findings We synthesized non-nitrogen (non N-BPs) containing bromobenzyl group (BP7033Br) chain were...
Multiple drug resistance is still an unsolved problem in cancer therapy. Our previous study demonstrated that the chemotherapeutic doxorubicin (Dox) induced upregulation of P-glycoprotein (P-gp) endothelial cells, resulting a 20-fold increase and reduced efficiency Dox treatment mice tumor model. In this study, we exposed human microvascular cells (HMEC-1) to sunitinib, tyrosine kinase receptor inhibitor, induce resistance. The results show sunitinib multiple these cells. They became...