Dawit Zewdu Wondafrash

ORCID: 0000-0003-1127-6443
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About
Contact & Profiles
Research Areas
  • Child Nutrition and Water Access
  • Global Maternal and Child Health
  • Ethnobotanical and Medicinal Plants Studies
  • Chemotherapy-induced organ toxicity mitigation
  • Malaria Research and Control
  • Sexual function and dysfunction studies
  • Food Security and Health in Diverse Populations
  • Complementary and Alternative Medicine Studies
  • Drug-Induced Hepatotoxicity and Protection
  • Nephrotoxicity and Medicinal Plants
  • Health Systems, Economic Evaluations, Quality of Life
  • Public Health and Nutrition
  • Phytochemistry and Bioactivity Studies
  • Food Science and Nutritional Studies
  • Pancreatic function and diabetes
  • Global Public Health Policies and Epidemiology
  • Garlic and Onion Studies
  • Neuroscience and Neuropharmacology Research
  • Moringa oleifera research and applications
  • Family Caregiving in Mental Illness
  • Drug-Induced Ocular Toxicity
  • Alzheimer's disease research and treatments
  • Global Health Care Issues
  • Pharmaceutical Practices and Patient Outcomes
  • Endoplasmic Reticulum Stress and Disease

St. Paul's Hospital Millennium Medical College
2025

Mekelle University
2019-2021

Addis Ababa University
2019-2020

Institute for Health Metrics and Evaluation
2019

University of Washington
2019

Auckland University of Technology
2019

Background Although diarrhea is a preventable disease, it continues to have significant impact on global health, with the burden being much greater in Sub-Saharan Africa. Medicinal plants represent affordable and locally available resources address many diseases, including diarrhea. Thus, this study aimed investigate antidiarrheal activities of 80% hydromethanolic crude extract solvent fractions Terminalia brownii Fresen (Combretaceae) leaves Swiss Albino mice. Methods This was carried out...

10.3389/fphar.2024.1510171 article EN cc-by Frontiers in Pharmacology 2025-01-27

Globally, cardiovascular diseases (CVDs) are becoming the major cause of death. Urtica simensis is one endogenous plant which treats a wide range disease conditions including heart diseases. However, there limited information on safety and efficacy plant.To evaluate in vitro antioxidant, vivo cardioprotective activity crude extract solvent fractions leaves cyclophosphamide-induced myocardial injury.The extract, aqueous hexane fraction was evaluated based anatomical, biochemical...

10.2147/jep.s270038 article EN cc-by-nc Journal of Experimental Pharmacology 2021-02-01

Hypertensive emergency (HE) is an acute stage of uncontrolled blood pressure which poses a substantial cardiovascular morbidity and mortality in developing countries. In our setting, the prevalence HE characteristics patients with hypertensive crisis are not certainly known yet.The study assessed associated factors among hospitalized crisis.A retrospective cross-sectional was conducted by reviewing records having diagnosis systolic/diastolic raised to more than 180/120 mmHg admitted Ayder...

10.2147/ibpc.s265183 article EN cc-by-nc Integrated Blood Pressure Control 2020-08-01

Abstract Background Diarrhoea has been the major cause of death especially in children developing countries. Brucea antidysenterica is one several medicinal plants used traditionally for treatment diarrhoea Ethiopia. Hence, present study was undertaken to investigate antidiarrhoeal and antibacterial activities root extract B. antidysenterica. Methods Plant material extracted by maceration technique using 80% methanol. The activity tested castor oil-induced diarrhoea, charcoal meal test,...

10.1186/s12906-020-03001-7 article EN cc-by BMC Complementary Medicine and Therapies 2020-06-30

Malaria remains a major worldwide public health problem leading to death of millions people. Spread and emergence antimalarial drug resistance are the challenge in malaria control. Medicinal plants key source new effective agents. Cordia africana (Lam.) is widely used for traditional management by local people different parts Ethiopia. The present study aimed evaluate vivo effects leaf extracts solvent fractions on Plasmodium berghei-infected mice.The were prepared tested oral acute toxicity...

10.1155/2019/8324596 article EN Evidence-based Complementary and Alternative Medicine 2019-08-18

Cyclophosphamide is an alkylating antineoplastic agent and its major limitation injury to normal tissue, leading multiple organ toxicity, including kidney, heart, liver reproductive toxicity. Croton macrostachyus (Euphorbiaceae) has been used in Ethiopian traditional medicine manage renal diseases.The present study aims assess the protective effect of stem bark extract solvent fractions on cyclophosphamide-induced nephrotoxicity rats.Nephrotoxicity was induced using cyclophosphamide 200...

10.2147/jep.s260731 article EN cc-by-nc Journal of Experimental Pharmacology 2020-08-01

Optimizing exit-knowledge of ambulatory patients is a major professional responsibility pharmacists to reassure safe and cost-effective medicines use. The study assessed the on their dispensed medications associated factors.Institutional-based cross-sectional was conducted among who visited outpatient pharmacy Ayder Comprehensive Specialized Hospital (ACSH) from December 2019 February 2020. Data were entered, cleaned, analyzed using SPSS version 20. Binary logistic regression employed...

10.2147/ppa.s267145 article EN cc-by-nc Patient Preference and Adherence 2020-08-01

Background: Mental illness is the leading cause of disability all over world greatly impacting several vulnerable groups particularly people living with Human Immunodeficiency Virus (HIV). Depression most common mental especially in human immunodeficiency virus and its prevalence increasing rapidly at an alarming rate among this group population. Objectives: The main aim study was to investigate severity depressive symptoms related factors patients Methods: An institutional-based...

10.2174/1874944502013010212 article EN The Open Public Health Journal 2020-05-23
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