A5071151212- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Mycobacterium research and diagnosis
- Galectins and Cancer Biology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Microbial infections and disease research
- Tuberculosis Research and Epidemiology
- Monoclonal and Polyclonal Antibodies Research
Cornell University
2024
Weill Cornell Medicine
2024
Boston Medical Center
2021-2022
Dandenong Hospital
1983
Walker (United States)
1983
Adolescents are a growing population of people living with HIV. The period between weaning and sexual debut presents low-risk window for HIV acquisition, making early childhood an ideal time implementing immunization regimen. Because the elicitation broadly neutralizing antibodies (bnAbs) is critical effective vaccine, our goal was to assess ability bnAb B cell lineage-designed envelope SOSIP (protein stabilized by disulfide bond gp120-gp41-named "SOS"-and isoleucine-to-proline point...
In humans, pre-existing anti-HIV-1 neutralizing antibodies (nAbs) have not been associated with decreased HIV-1 acquisition. Here, we evaluate antibody-dependent cellular cytotoxicity (ADCC) present in pre-transmission infant and maternal plasma breast milk (BM) against the contemporaneous variants. HIV-1-exposed uninfected compared infected infants higher ADCC a combination of nAb responses their corresponding mother's strains. does correlate nAbs, suggesting they are independent...
HIV-1 vaccine efforts are primarily directed toward eliciting neutralizing antibodies (nAbs). However, trials and mother-to-child natural history cohort investigations indicate that antibody-dependent cellular cytotoxicity (ADCC), not nAbs, correlate with prevention. The ADCC characteristics associated lack of acquisition remain unclear. Here, we examine nAb properties in pretransmission plasma from HIV-1–exposed infants the corresponding transmitting nontransmitting mothers' breast milk...
An outbreak of tuberculosis due to Mycobacterium bovis in cats an animal house was investigated. It concluded that the index case infected by ingestion contaminated meat obtained from a knackery and some other cases were inhalation tubercle bacilli shed discharging sinus case. A possum also research worker apparently received significant challenge.
SummaryIn humans, pre-existing anti-HIV-1 neutralizing antibodies (nAbs) have not been associated with decreased HIV-1 acquisition. We evaluated antibody-dependent cellular cytotoxicity (ADCC) present in pre-transmission infant and maternal plasma breast milk (BM) against the contemporaneous variants. exposed uninfected as compared to infected infants had higher ADCC a combination of nAb responses their corresponding mother’s strains. did correlate nAbs suggesting they are independent...