A5066833582- EFL/ESL Teaching and Learning
- Epigenetics and DNA Methylation
- Microbial Natural Products and Biosynthesis
- International Student and Expatriate Challenges
- Second Language Learning and Teaching
- Plant biochemistry and biosynthesis
- Discourse Analysis in Language Studies
- Biochemical and Molecular Research
- Second Language Acquisition and Learning
- Islamic Finance and Communication
- Asymmetric Hydrogenation and Catalysis
- Architecture and Computational Design
- Financial Reporting and Valuation Research
- Auditing, Earnings Management, Governance
- Enzyme Structure and Function
- Computational Drug Discovery Methods
- Higher Education Governance and Development
- Nanoplatforms for cancer theranostics
- Cancer-related gene regulation
- Financial Markets and Investment Strategies
- Microbial Metabolic Engineering and Bioproduction
- Natural Language Processing Techniques
- Extracellular vesicles in disease
- HIV/AIDS drug development and treatment
- Amino Acid Enzymes and Metabolism
Pennsylvania State University
2023-2025
Chinese University of Hong Kong
2025
Chinese University of Hong Kong, Shenzhen
2022-2024
Sun Yat-sen University
2018-2022
University of Auckland
2018
Abstract C2′-halogenation has been recognized as an essential modification to enhance the drug-like properties of nucleotide analogs. The direct C2ʹ-halogenation 2′-deoxyadenosine-5′-monophosphate (dAMP) recently achieved using Fe(II)/α-ketoglutarate-dependent halogenase AdaV. However, limited substrate scope this enzyme hampers its broader applications. In study, we report two halogenases capable halogenating 2ʹ-deoxyguanosine monophosphate (dGMP), thereby expanding family halogenases....
Natural products are the major resource of drug discovery, and terpenoids represent largest family natural products. Terpenome is defined as all terpenoid-like terpenoid-derived compounds, including terpenoids, steroids, their derivatives. Herein, aiming to navigate chemical biological space terpenome, first comprehensive database dedicated terpenome research has been developed by collecting over 110 000 molecules from various resources, distributed in 14 351 species, belonging 1109...
Abstract With the growing use of corpora in second language (L2) research, examining role writing topics alongside first (L1) background and L2 proficiency shaping usage has become increasingly important. This study contributes to this line inquiry by using a learner corpus 1,198 argumentative essays explore how topics, tandem with L1 proficiency, influence ‘V that’ clauses (e.g., I think that it is important… ) among English as Foreign Language (EFL) writers. The findings reveal significant...
d-Cycloserine (DCS), an antibiotic used in the treatment of drug-resistant tuberculosis, was traditionally believed to irreversibly inhibit pyridoxal-5'-phosphate (PLP)-dependent alanine racemase from Mycobacterium tuberculosis (MtAlr). However, recent research suggests that inhibition is reversible, as MtAlr can be reactivated by destructing DCS. This study employs hybrid quantum mechanics/molecular mechanics (QM/MM) method investigate mechanisms and DCS destruction. Computational results...
We closely replicated Ellis and Sagarra (2010b), a seminal, frequently cited, theoreticallyimportant study that demonstrated blocking effects in adult L2 learning. In study, Englishspeakinglearners completed different types of pretraining about Latin temporal expressions(adverbs, verbs, no pretraining) to investigate how knowledge specific cues influenced L2outcomes. Results showed the type received strongly influencedcomprehension production. To date, however, these findings have not been...
The importance of academic journals in second language (L2) research is evident on at least two levels. Journals are, first all, central to the process disseminating scientific findings. are also critical a professional level as most L2 researchers must publish articles advance their careers. However, not all perceived equal; some may be considered more prestigious or higher quality and may, therefore, achieve greater impact field. It therefore necessary that we understand identity journals,...
Abstract This article presents selected results from a large‐scale, mixed‐methods, federally funded investigation of US‐based language study‐abroad alumni all ages, which included nationwide survey ( N = 4,899) followed by professional life history interviews with 54 participants. Here, we focus on three questions heretofore unaddressed: (a) How do these continue to use their additional languages? (b) is long‐term associated various program features? and (c) the role features reflected in...
The detailed reaction mechanism of bCinS catalyzing the substrate NPP was explored by multiscale simulations. enzyme experiences “closed-A” state to generate ( S )-terpineol, and then changes “closed-B” for 1,8-cineole production.
Abstract This paper examines management forecast errors in initial public offering ( IPO ) prospectuses of New Zealand firms and subsequent explanations for earnings recent years. has several unique features changes that are worthy research, including the requirement to make forecasts; a explain differences between actual; change provides voluntary opportunity obtain negative assurance opinion on forecasts. Using hand‐collected data 1998 2014, we find include prospective financial...
The perturbations of DNA methyltransferase 3 alpha (DNMT3A) may cause uncontrolled gene expression, resulting in cancers and tumors. DNMT inhibitors Azacytidine (AZA) Zebu-larine (ZEB) inhibit the family with no specificities consequently would bring side effects during treatment. Therefore, it is vital to understand their inhibitory mechanisms DNMT3A inform new inhibitor design for DNMTs. Herein, we carried out molecular dynamics (MD) quantum mechanics/molecular mechanics (QM/MM)...
The perturbations of DNA methyltransferase 3 alpha (DNMT3A) may cause uncontrolled gene expression, resulting in cancers and tumors. DNMT inhibitors Azacytidine (AZA) Zebularine (ZEB) inhibit the family with no specificities, consequently would bring side effects during treatment. Therefore, it is vital to understand inhibitory mechanisms DNMT3A inform new inhibitor design for DNMTs. Herein, we carried out molecular dynamics (MD) quantum mechanics/molecular mechanics (QM/MM) simulations...
Microbe class I terpene cyclases (TPCs) are responsible for deriving numerous functionally and structurally diverse groups of terpenoid natural products. The conformational change their active pockets from "open" state to "closed" upon substrate binding has been clarified. However, the key structural basis relevant this pocket dynamics its detailed molecular mechanism still unclear. In work, on (MD) two microbe TPCs (SdS bCinS), we propose that is highly dependent residue orientation...