A5084827601- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research
- Hematopoietic Stem Cell Transplantation
- Clinical Laboratory Practices and Quality Control
- Blood transfusion and management
- Blood properties and coagulation
- Sepsis Diagnosis and Treatment
- Hemostasis and retained surgical items
- Heparin-Induced Thrombocytopenia and Thrombosis
- Atrial Fibrillation Management and Outcomes
- Acute Myeloid Leukemia Research
- Platelet Disorders and Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrest and Resuscitation
- Neutropenia and Cancer Infections
- Trypanosoma species research and implications
- Blood donation and transfusion practices
- Vitamin K Research Studies
- Collagen: Extraction and Characterization
- Heart Failure Treatment and Management
- Venomous Animal Envenomation and Studies
- Renal Transplantation Outcomes and Treatments
- Mechanical Circulatory Support Devices
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Prince Charles Hospital
2013-2014
The University of Queensland
2013-2014
Princess Alexandra Hospital
1990-2014
Hospital Clínico Universitario de Valencia
2010-2012
Queensland Health
2001
Princess Alexandra Hospital
1994
Background Allogeneic hematopoietic stem cell transplantation is an effective treatment for patients with poor risk lymphoma, at least in part because of the graft-versus-lymphoma effect. Over past decade, reduced intensity conditioning regimens have been shown to offer results similar those conventional high-dose but lower toxicity early after transplantation, especially chemosensitive disease transplant.Design and Methods The aim this study was analyze long-term outcome follicular lymphoma...
The graphical representation of clotting data can provide useful information. A novel feature the ACL TOP software allows display clot reaction curves with superimposed first and second derivative curves. We noted atypical plots associated normal 'S'-shaped in some abnormal activated partial thromboplastin time (APTT).We tested 179 citrate plasmas four different APTT reagents on TOP. documented prevalence utility these patients.Ellagic acid commonly produce despite Occasionally, may cause...
Different types of graft-versus-host disease prophylaxis have been proposed in the setting reduced intensity and non-myeloablative allogeneic stem cell transplantation. An alternative combination with sirolimus tacrolimus has recently tested although comparative studies against classical a calcineurin inhibitor mycophenolate mofetil or methotrexate are lacking. We describe results prospective, multicenter trial using + as immunoprophylaxis, compare this approach our previous experience...
This is the first prospective study of deferasirox in adult allogeneic hematopoietic stem cell transplant recipients with transfusional iron overload hematologic malignancies. Patients at least six months post were treated a starting dose 10 mg/kg/day for 52 weeks or until serum ferritin was less than 400 ng/mL on two consecutive occasions. Thirty patients enrolled and 22 completed study. A significant reduction from baseline median liver concentration observed overall population: 1440 to...
Background and Objectives Transfusion of blood products in particular older is associated with patient morbidity. Previously, we demonstrated a higher incidence acute lung injury lipopolysaccharide‐treated sheep transfused stored products. As transfusion following haemorrhage more common, aimed to determine whether ‘first hit’ isolated would precipitate similar detrimental effects also disrupt haemostasis. Materials Methods Anaesthetized had 33% their total volume collected into Leukotrap...
We aimed to assess the utility of HitAlert flow cytometry as a diagnostic functional heparin-induced thrombocytopenia (HIT) assay in tertiary care hospital. The 4Ts score was used pretest probability HIT 37 patients. Serum analysed for antibodies by assay. Results were compared with an antigenic assay, particle gel immunoassay, PaGIA ID PF4/Hep Ab assay; and two assays, Multiplate whole blood impedance aggregometry (WBIA), serotonin release (SRA). Flow positive 14 out patients, including...
Low molecular weight heparins (LMWHs) are used for prevention and management of vascular thrombosis. In general, monitoring anticoagulant activity is not required, however, certain populations may be susceptible to overdosing or underdosing. As anti-activated factor X(anti-Xa) testing readily available, it was our aim investigate the usefulness thromboelastography (TEG; Haemoscope Corporation, Skokie, Illinois, USA) assessment coagulation in patients on LMWH. All admitted coronary care unit...
Background Currently, no clear guidelines exist for the most appropriate tests to determine sample quality from centrifugation protocols plasma types with both lithium heparin in gel barrier tubes biochemistry testing and citrate coagulation testing. Methods Blood was collected 14 participants four one serum tube barrier. The were centrifuged at different centrifuge settings analysed potassium (K + ), lactate dehydrogenase (LD), glucose phosphorus (Pi) zero time, poststorage six hours 21 °C...
AbstractSixty-one adult patients with relapsed or refractory acute myelogenous leukemia (AML) were treated in a cooperative study Idarubicin 12 mg/m2/day on days 1 to 3 and AraC lg/m2/12h 4. Responding scheduled for consolidation Ida-IDAraC bone marrow transplantation (BMT) when feasible. Twelve of 23 (52%) 21 38 (55%) achieved complete remission (CR). Refractory very early (CR 63%) initial CR > 6 months 68%) the subgroups better rate. The only factor influencing disease free survival (DFS)...
Summary Echis carinatus venom contains proteases capable of activating both normal and descarboxy prothrombin. We showed this (Sigma) principally activates prothrombin with almost no factor X activation. time in combination can predict vitamin K responsiveness since the is usually presence associated deficiency. 38 patients abnormal routine times (PT) had coagulant immunogenic II assays along done before after K. Of 22 responding to K, based on correction PT, 21 initial 16 not responding, 11...
We compared the performance characteristics of a commercial dilute Russell's viper venom (DRVV)-based APC resistance assay (Gradipore PC Impedance Test) to routinely utilized APTT based (Coatest Resistance Assay). The DRVV offers improved sensitivity and specificity for factor V Leiden mutation. However, routine use both assays provides optimum reliability diagnosis genetic resistance. Our results suggest that when tests are either positive or negative, DNA analysis is unnecessary....