A5070485740- Blood Pressure and Hypertension Studies
- Nitric Oxide and Endothelin Effects
- Cardiovascular Health and Disease Prevention
- Health and Lifestyle Studies
- Birth, Development, and Health
- Cardiovascular Health and Risk Factors
- Sodium Intake and Health
- Cardiac and Coronary Surgery Techniques
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Renal and Vascular Pathologies
- Heart Rate Variability and Autonomic Control
- Eicosanoids and Hypertension Pharmacology
- COVID-19 Clinical Research Studies
- Trypanosoma species research and implications
- Atherosclerosis and Cardiovascular Diseases
- Obesity, Physical Activity, Diet
- Biochemical effects in animals
- Congenital Heart Disease Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Health and Medical Education
- Cardiac Ischemia and Reperfusion
- Healthcare Systems and Public Health
- Pregnancy and preeclampsia studies
- Cardiac Health and Mental Health
National University of Tucumán
2001-2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2008-2023
Instituto Superior de Investigaciones Biológicas
2001-2023
Centro Científico Tecnológico - Tucumán
2023
Introducción: La comunidad Quilmes (Tucumán) abarca 2400 habitantes de media y alta montaña (1800 a 4000 metros sobre el nivel del mar). El objetivo presente trabajo fue conocer su estado salud cardiovascular. Material métodos: Se efectuó una investigación cuantitativa descriptiva transversal en personas pertenecientes dicha que asistieron voluntariamente los días 27 29 septiembre 2018 la evaluación prevista. Resultados: estudiaron 202 pobladores (125 mujeres 77 varones; 48 ± 1,4 años). 23%...
Previously, our group showed a prothrombotic state in asymptomatic patients with chronic Chagas disease. The current paper studies the inflammatory status and endothelial function these patients. Methods: In 40 healthy volunteers, we evaluated state, blood parasitemia (molecular biology: polymerized chain reaction [PCR]-amplification), tissue factor pathway inhibitor antibodies (aTFPI), interleukin 6 (IL-6), vascular cell adhesion molecule-1 (VCAM-1). Endothelial was determined by reactive...
<b><i>Background:</i></b> Obesity is related to an increase in the rates of cardiovascular disease. <b><i>Objective:</i></b> To establish impact obesity on vascular function (endothelial and arterial stiffness) children adolescents its relationship risk factors. <b><i>Methods:</i></b> In obese (OB) adolescents, endothelial stiffness were evaluated by a pulse plethysmography method (reactive hyperemia index digital volume...
We investigated the effects of extraendothelial nitric oxide (NO) on angiotensin II (Ang II) reactivity in internal mammary artery (IMA) rings, as well impact hypertension without associated risk factors this response. Vascular reactivity, NO levels, and resting membrane potentials were determined hypertensive (HT) normotensive (NT) IMA rings. Only rings with endothelial dysfunction included. Ang produced a dose-dependent contraction that was higher HT Response to potentiated by Nω-nitro...
Low birthweight (LBW) increases the risk of developing cardiovascular diseases (CVD). Few studies have established its impact at early ages.To study endothelial function (EF) and arterial stiffness (AS) their relationship to markers CVD in children with LBW.In LBW (4-6 years; n = 53), anthropometric, haemodynamic laboratory parameters, including HOMA-IR, hs-CRP, adiponectin leptin, were determined. EF AS evaluated by digital pulse plethysmography. Data compared a control group (n 33).In both...
Background. The internal mammary artery (IMA) used in bypass coronary surgery remains efficient for a longer time than other grafts, such as saphenous veins; however, its biological characteristics are incompletely defined. Objective. To compare IMA grafts from hypertensive (HT) and normotensive (NT) patients the presence of endothelium their functionability, response to passive stretching basal tone, reactivity exogenous vasoconstrictors, role NO release, possible extraendothelial source....
Nonischemic 5/6 nephrectomized rat (NefR) is a model of chronic kidney disease. However, little known about vascular dysfunction and its relation with hypertension in NefR. Aims. To evaluate possible alterations endothelial function, NO-bioavailability, basal tone aorta from NefR the role oxidative stress. Sprague Dawley rats were divided into sham (SR), NefR, treated tempol (NefR-T). Mean arterial pressure (MAP) renal function determined. In isolated aortic rings following was measured:...
<i>Background/Aim:</i> We evaluated in diabetic-streptozotocin rats (STZR) the structural changes of glomeruli, preglomerular vessels, glomerular tuft and renal parenchyma order to determine degree injury presence remodeling afferent arterioles developed by diabetes without overimposed hypertension. <i>Methods:</i> Renal mass index histological score (glomerular number, density, tubular lesions arteriosclerosis) were estimated. In ratio wall thickness/lumen was...
Objective . To evaluate the impact of oxidative stress on vascular reactivity to vasoconstrictors and nitric oxide (NO) bioavailability in saphenous vein (SV) graft with endothelial dysfunction from hypertensive patients (HT). Methods Endothelial function, reactivity, state, nitrites NO release were studied isolated SV rings HT normotensive (NT). Only used. Results presented a hyperreactivity that was reverted by diphenylene iodonium (DPI). In NT, no effect DPI obtained, but...
Renal preglomerular vessels play a central role in modulating renal function and injury, especially during conditions of hemodynamic stress such as hypertension. We evaluated whether improving the balance between nitric oxide (NO) oxidative improves morphological alterations afferent arterioles that occur NO deficiency-induced hypertension.We measured indices morphology arteriolar remodeling rats treated with vehicle, L-NAME or plus tempol (a superoxide dismutase mimetic) for 6...
We investigated structural alterations in renal tissue identifying the morphological and histological changes non-ischemic kidney (NIK) their potential significance aortic coarctation-hypertensive rats (HR). HR's mean arterial pressure (MAP) was higher compared with sham operated (SR). An oral 10 mg/kg/day losartan (LOS) dose diminished but not reverted MAP. Hypertrophy noted HR NIK's significant weight increase (p< 0.01). The ratio IK/NIK decreased 22% (p<0.01). LOS proved to cause no...
Background: The community of Quilmes (Tucumán) encompasses 2400 mid- and high mountain inhabitants (1800 to 4000 meters above sea level). In 2018, a study was carried out on their cardiovascular health status (2018 SONQO-CALCHAQUÍ Program). Objective: aim this is update expand the survey in obtain broader panorama community. Methods: A descriptive cross-sectional community, people who voluntarily attended specially established clinics September 2022. Questionnaires, laboratory tests, ECG,...
Introducción: En reportes anteriores de nuestro grupo trabajo se demostró que la población originaria Quilmes (Tucumán) presenta un alto índice sobrepeso y obesidad régimen alimentario occidentalizado. Para evaluar si estas características son compartidas por otras comunidades originarias los Valles Calchaquíes llevó a cabo el Programa SONQO-CALCHAQUÍ III (Edición 2023). Objetivo: Evaluar variables cardiovasculares en tres sus posibles diferencias. Material métodos: Estudio descriptivo...
This study aimed to evaluate vascular function changes and autonomic balance during the first trimester of pregnancy its relationship with new-born weight. prospective performed in pregnant (PG) women after delivery (not pregnant: NPG) evaluated endothelial (EF) arterial stiffness (AS) by a non-invasive method. We heart rate variability (HRV), parasympathetic nervous system (PNS), sympathetic (SNS) indexes electrocardiogram (5 min) urinary nitrite excretion (NOx). PG increased EF NOx...
Background: The Quilmes community includes 2,400 inhabitants of the middle and high mountains Tucumán (1,800 to 4,000 meters above sea level). purpose present study was know their cardiovascular health status. Methods: A cross-sectional descriptive quantitative investigation carried out in people belonging who voluntarily attended planned evaluation on September 27-29, 2018. Results: Two hundred two settlers were studied (125 women 77 men; 48±1.4 years), 23% them had hypertension (HTN); 14%...
Objetivos: Determinar los programas y proyectos de investigacion e intervencion, incluyendo diagnosticos salud, entre Abril 2001 a Diciembre del 2007, en la Provincia Tucuman, Argentina. Materiales Metodos: Para cientifica salud se utilizo base datos Consejo Nacional Investigaciones Cientificas Tecnicas (CONICET) Universidad Tucuman (UNT). las investigaciones socio-sanitarias realizaron entrevistas actores claves involucrados gestion conocimiento, funcionarios gobierno Ministerio Salud...
Introduction: Cardiovascular events are the leading cause of mortality in patients with chronic kidney disease on hemodialysis (CKD-HD). Recent evidence suggests that coronavirus-19 (COVID-19) would induce vascular endothelial function alterations to increase cardiovascular risk. However, whether COVID-19 contributes dysfunction CKD-HD is unclear. Objective: To assess worsens a cohort hemodialysis. Materials and Methods: Patients were divided into those without (CKD; n = 68) mild (CKD-C19;...
The changes in endothelial function, arterial stiffness, and heart rate variability (HRV) produced the first trimester of pregnancy women who develop gestational hypertension (GH) are still being investigated. Objective: to evaluate HVR, stiffness during their relationship with development GH.A group normotensive (n = 43), later did (GH; n 11) or not (no-GH; 32) GH that pregnancy, were enrolled. In trimester, function evaluated through photoplethysmography. HRV, parasympathetic (PNS),...
Introducción. Durante la pandemia de COVID-19 el uso telemedicina aumentó considerablemente como una alternativa para prestar atención en salud. En este contexto, surgió Consultorio Virtual Cardiología del Sistema Provincial Salud Tucumán, Argentina (SIPROSA). Objetivo. Describir las características pacientes con o sin diagnóstico previo hipertensión arterial (HTA y no-HTA, respectivamente) que fueron valorados mediante teleconsulta SIPROSA durante por debido a cifras elevadas presión (PA).....