A5055665751- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Neurological Complications and Syndromes
- Hepatitis C virus research
- Cardiac, Anesthesia and Surgical Outcomes
- Hepatitis B Virus Studies
- Electrolyte and hormonal disorders
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood transfusion and management
- Acute Kidney Injury Research
- Anesthesia and Sedative Agents
- Cardiovascular Issues in Pregnancy
- Respiratory Support and Mechanisms
- Cardiac Imaging and Diagnostics
- Hemoglobinopathies and Related Disorders
- Neurosurgical Procedures and Complications
- Hemodynamic Monitoring and Therapy
- Pulmonary Hypertension Research and Treatments
- Renal and Vascular Pathologies
- Heart Failure Treatment and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Ronald Reagan UCLA Medical Center
2014-2024
University of California, Los Angeles
2015-2024
Los Angeles Medical Center
2020-2021
UCLA Health
2015
Victor (Japan)
2015
GTx (United States)
2010
TCL (China)
2010
In Brief Objective: To analyze incidence, outcomes, and utilization of health care resources in liver transplantation (LT) for nonalcoholic steatohepatitis (NASH). Summary Background Data: With the epidemic obesity metabolic syndrome nearly 33% US population, NASH is projected to become leading indication LT next several years. Data on predictors outcome after limited. Methods: We conducted an analysis from our prospective database 144 adult patients who underwent between December 1993...
To analyze a 28-year single-center experience with orthotopic liver transplantation (OLT) for patients irreversible failure.The implementation of the model end-stage disease (MELD) in 2002 represented fundamental shift donor allocation to recipients highest acuity, raising concerns about posttransplant outcome and morbidity.Outcomes factors affecting survival were analyzed 5347 consecutive OLTs performed 3752 adults 822 children between 1984 2012, including comparisons recipient...
Early allograft dysfunction (EAD) following a liver transplant (LT) unequivocally portends adverse graft and patient outcomes, but widely accepted classification or grading system is lacking.To develop model for individualized risk estimation of failure after LT then compare the model's prognostic performance with existing binary EAD definition (bilirubin level ≥10 mg/dL on postoperative day 7, international normalized ratio ≥1.6 aspartate aminotransferase alanine >2000 U/L within first 7...
Background. Surgical site infection (SSI) is a common postoperative complication associated with increased morbidity and mortality in patients undergoing liver transplantation (LT). Although intraoperative hyperglycemia has been shown to be adverse outcomes including overall rate LT patients, relationship between SSI not established. We sought determine if was after LT. Methods. Patients at our medical center January 2004 November 2007 were included the study. Recipient, donor, variables...
Acute renal injury (ARI) and acute failure (ARF) are serious complications after liver transplantation (LT). Few studies apply the risk, injury, function, loss, end-stage criteria on patients who have normal preoperative function. The aims of this study were to identify incidence, risk factors, impact ARI ARF in patient population.After institutional review board approval, adult LT had serum creatinine less than or equal 1.5mmol/L reviewed. Postoperative determined by criteria. Risk factors...
Objective: We sought to evaluate outcomes and predictors of renal allograft futility (RAF—patient death or need for replacement therapy at 3 months) after simultaneous liver-kidney transplantation (SLKT). Background: Model End-Stage Liver Disease (MELD) prioritization liver recipients with dysfunction has significantly increased utilization SLKT. Data on SLKT in the highest MELD are scarce, as accurate recovery native kidney function. Without well-established listing guidelines, potentially...
Background. Critically ill cirrhotic patients are increasingly transplanted, but there is no consensus about futile liver transplantation (LT). Therefore, the decision to delay or deny LT often extensively debated. These debates arise from different opinions of futility among transplant team members. This study aims achieve a multinational and multidisciplinary on definition in develop well-articulated criteria for not proceeding with due futility. Methods. Thirty-five international experts...
Recent changes in organ allocation based on the model for end-stage liver disease (MELD) prioritize most ill patients waiting list transplantation. While undergoing transplantation MELD era are more acutely ill, impact of policy perioperative management has not been completely assessed. We retrospectively reviewed records 124 primary adult transplant patients. Patients were divided into low (< or = 30) and high (>30) score groups. Preoperative characteristics intraoperative compared between...
In Brief BACKGROUND: Hyperkalemia poses serious hazards to patients undergoing orthotopic liver transplantation (OLT), and its predictors have not been thoroughly examined. METHODS: We retrospectively studied 1124 consecutive adult who underwent OLT. was defined as serum K+ ≥5.5 mmol/L. A total of 47 recipient, donor, intraoperative, laboratory variables were initially analyzed in univariate analyses. Independent hyperkalemia three periods OLT (prereperfusion, early postreperfusion, late...
Postoperative atrial fibrillation (POAF) is common after major surgeries and associated with increased morbidity mortality. POAF liver transplantation (LT) has not been reported. This study was undertaken to investigate the incidence, impact, risk factors of in LT patients. After IRB approval, between January 2006 August 2013 at our center were retrospectively reviewed. that occurred within 30 days included. Patients without compared independent identified by logistic regression. Of 1387...
The Model for End-Stage Liver Disease (MELD) system has dramatically increased the number of recipients requiring pretransplant renal replacement therapy (RRT) prior to liver transplantation (LT). Factors affecting post-LT outcomes and need intraoperative RRT (IORRT) were analyzed in 500 consecutive receiving RRT, including comparisons among not IORRT (No-IORRT, n = 401), planned (Pl-IORRT, 70), emergent, unplanned after LT initiation (Em-IORRT, 29). Despite a median MELD 39, overall 30-day,...
Donation after cardiac death (DCD) is an important source for expanding the donor pool liver transplantation (LT). Although long-term outcomes of LT using DCD grafts have been extensively studied, perioperative complications related to are rarely reported. The aim this study was determine whether were associated with a higher incidence postreperfusion and worse in adult patients. After institutional review board approval, medical records all patients who underwent at our center between 2004...
Even though numerous cases of massive thromboemboli have been reported in the literature, intracardiac (ICTs) incidentally found during orthotopic liver transplantation (OLT) not examined. In this study, we retrospectively examined incidence, risk factors, and management incidental ICTs OLT. After institutional review board approval, adult patients who underwent OLT between January 2004 December 2008 at our center were reviewed. identified confirmed by examination datasheets, anesthesia...
To determine the risk factors for stage 3 and 4 fibrosis in a large cohort of U.S. patients with chronic hepatitis C (CHC).Multiple host viral affect outcomes CHC. Further defining pathogenic roles these CHC progression will lead to improving management this disease.Retrospective study US CHC.Of 460 patients, 331 were males 129 females mean age 48.4+/-8.0 years, 191 (41.7%) had fibrosis. Clinically, multivariate analysis revealed that > or =60 years at presentation, estimated duration virus...
Background. Although hemorrhage is a major concern during liver transplantation (LT), the risk for thromboembolism well recognized. Implementation of rotational thromboelastometry (ROTEM) has been associated with increased use cryoprecipitate; however, role ROTEM-guided transfusion strategy and cryoprecipitate administration in development thromboembolic complications (MTCs) never documented. Methods. We conducted study on patients undergoing LT before after implementation ROTEM. defined MTC...
Although the hemodynamic benefits of venovenous bypass (VVB) during liver transplantation (LT) are well appreciated, impact VVB on posttransplant renal function is uncertain. The aim this study was to determine if associated with a lower incidence acute kidney injury (AKI).Medical records adult (≥18 years) patients who underwent primary LT between 2004 and 2014 at tertiary hospital were reviewed. Patients required pretransplant replacement therapy intraoperative piggyback technique excluded....
Myocardial injury, defined as an elevation of cardiac troponin (cTn) resulting from ischemia, is associated with substantial mortality in surgical patients, and its incidence, risk factors, impact on patients undergoing liver transplantation (LT) are poorly understood. In this study, adult who experienced perioperative hemodynamic derangements had cTn measurements within 30 days after LT between 2006 2013 were studied. Of 502 203 (40.4%) met the diagnostic criteria (cTn I ≥0.1 ng/mL)...
The incidence of HCC is rising worldwide. Studies on ethnicity-based clinical presentation remain limited. aim to compare the and stage between Asian-Americans non-Asian-Americans. This retrospective study assessed differences in presentation, including demographics, laboratory results, diagnosis underlying liver disease, HCC. Of 276 patients, 162 were 114 Compared non-Asian-Americans, had a significantly higher history hepatitis B virus (HBV) infection (55.0% vs. 4.9%, P < 0.001), family...