A5084795817- Antibiotic Use and Resistance
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Kidney Injury Research
- Neonatal and Maternal Infections
- Antimicrobial Resistance in Staphylococcus
- Meta-analysis and systematic reviews
- Streptococcal Infections and Treatments
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Global Public Health Policies and Epidemiology
- Congenital Heart Disease Studies
- Diverse Scientific Research Studies
- Parasites and Host Interactions
- Bacteriophages and microbial interactions
- Antibiotics Pharmacokinetics and Efficacy
- Vaccine Coverage and Hesitancy
- Abdominal Surgery and Complications
- HIV/AIDS Impact and Responses
- Biosimilars and Bioanalytical Methods
- Aquaculture disease management and microbiota
- Clinical Laboratory Practices and Quality Control
- Health Systems, Economic Evaluations, Quality of Life
- Biomedical Text Mining and Ontologies
- Parasite Biology and Host Interactions
University of Liverpool
2023-2025
Aintree University Hospitals NHS Foundation Trust
2023-2025
Imperial College London
2020-2021
University of Birmingham
2020
ABSTRACT Effective policy to address the global threat of antimicrobial resistance requires robust susceptibility data. Traditional methods for measuring minimum inhibitory concentration (MIC) are resource intensive, subject human error, and require considerable infrastructure. AIgarMIC streamlines standardizes MIC measurement is especially valuable large-scale surveillance activities. MICs were measured using agar dilution n = 10 antibiotics against clinical Enterobacterales isolates (...
Abstract Highly pathogenic emm1 Streptococcus pyogenes strains secrete the multidomain Streptococcal inhibitor of complement (SIC) that binds and inactivates components innate immune response. We aimed to determine if naturally occurring or vaccine-induced antibodies SIC are protective against invasive S. infection. Immunisation with full-length protected mice systemic bacterial dissemination following intranasal intramuscular infection . Vaccine-induced rabbit anti-SIC antibodies, but not...
Vibrio alginolyticus is one of the major disease-causing bacteria in shrimp aquaculture. The widespread use antibiotics aquaculture to treat bacterial diseases has raised concerns about antibiotic resistance. As a result, alternative treatments, such as plant extract phytochemicals are being explored mitigate these risks. This study aims identify promising biologically active compounds from garlic (Allium sativum) that can inhibit virulent protein thermolabile hemolysin V. alginolyticus,...
ABSTRACT Blood cultures are central to the management of patients with sepsis and bloodstream infection. Clinical decisions depend on timely availability laboratory information, which, in turn, depends optimal processing specimens. Discrete event simulation (DES) offers insights into where optimization efforts can be targeted. Here, we generate a detailed process map blood culture within use it build simulator. Direct observation staff was used flowchart pathway. Retrospective routinely...
Background: Effective policy to address the global threat of antimicrobial resistance requires robust susceptibility data. Traditional methods for measuring minimum inhibitory concentration (MIC) are resource intensive, subject human error, and require expensive equipment operate at scale. AIgarMIC streamlines standardises MIC measurement use in a range health settings.Methods: MICs were measured using agar dilution variety antibiotics against clinical gram-negative strains (n=1086),...
Abstract Highly pathogenic emm1 Streptococcus pyogenes strains secrete the multidomain Streptococcal inhibitor of complement (SIC) that binds and inactivates components innate immune response. We aimed to determine if naturally occurring or vaccine-induced antibodies SIC are protective against invasive S. infection. Immunisation with full length protected mice systemic bacterial dissemination following intranasal intramuscular infection pyogenes. Vaccine-induced rabbit anti-SIC antibodies,...