Headache is one of the most common neurologic symptoms Behçet's disease (BD) that may be due to migraine, tension-type headache, uveitis, or direct consequence neuro-Behçet's (NBD) other causes.To study prevalence and characteristics different types headache in patients with BD.Subjects were recruited as consecutive who referred Clinic at Nemazee Hospital, Shiraz, Southern Iran, from March 2004 2006. All fulfilled International Study Group criteria for BD. Each patient was interviewed...

To investigate the association between tumor necrosis factor-alpha (TNF-alpha) G-308A, factor-beta (TNF-beta) G+252A and interleukin-4 (IL-4) C-590T polymorphisms susceptibility to multiple sclerosis (MS) development clinical course of disease.Two hundred seventy patients with MS 542 sex ethnic matched controls were enrolled in present study. An allele-specific oligonucleotide polymerase chain reaction was used detect polymorphism at position -308 TNF-alpha gene. The genotypes TNF-beta IL-4...

Osteoarthritis affects about 50% of people aged older than 65 years. Pain is the most important symptom in this disease. Today public interest use complementary medicine, especially traditional herbal medicines has increased. The present study was designed to investigate efficacy preparation Peganum harmala L oil on patients with knee osteoarthritis. product been analyzed and standardized by high-performance liquid chromatography. A double blind controlled randomized clinical trial...

Rheumatoid arthritis (RA) is a chronic progressive inflammatory disease that causes joint destruction. The condition imposes significant economic burden on patients and societies. present study aimed at evaluating the cost-effectiveness of Infliximab, Adalimumab, Etanercept in treating rheumatoid Iran.This evaluation which Markov model was used. carried out 154 with Fars province taking Etanercept. were selected through sampling. In this study, cost data collected from community perspective,...

The frequency of the Fas gene polymorphism at positions-1377 G/A and -670 A/G in 249 patients with systemic lupus erythematosus (SLE) 212 healthy controls were investigated using allele-specific polymerase chain reaction. On evaluation genotype allelic distributions position -670, no significant difference was observed between controls. At -1377, GG G allele higher patient group than control (p < 0.036). haplotype frequencies showed a = 0.045). association these polymorphisms ligand serum...

Behcet's disease (BD) is a chronic multisystem autoimmune disorder. Various cytokines take part in the pathogenesis of this disease. Interleukin (IL)-38, new member IL-1 cytokine family, has been reported to have anti-inflammatory properties; however, its role BD not investigated yet. In study, we aimed examine probable IL-38 clinical context BD. A total 81 patients with and age- sex-matched healthy subjects as controls were included study. The serum levels measured sera using enzyme-linked...

Idiopathic uveitis is the most common form of in countries. Uveitis affects about 40-80% patients with Behçet's disease (BD). Class I, HLA-B5, and its subclass B51 allele have strongest association BD, but role idiopathic unclear. The aim this study was to determine frequency HLA-B51 HLA-B27 uveitis, BD control group.Forty-eight 62 49 subjects were compared. presence checked by reviewing charts referred rheumatologic center Shiraz University Medical Sciences. group consisted a sex-matched...

Celiac disease (CD) is a common enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. It frequently found conjunction with other autoimmune diseases. The purpose this study was to investigate prevalence CD patients juvenile idiopathic arthritis (JIA) and those rheumatoid (RA) southwestern Iran.A total 53 children JIA 55 adults RA were enrolled. Anti-tissue transglutaminase (tTG) immunoglobulin (Ig) A serum levels measured performing an enzyme-linked...

Behcet's disease (BD) is a multisystem of unknown etiology. There are several clues which may indicate an ethiopathogenesis role for Helicobacter pylori infection in this disease. In case control study out patient department, 48 patients with BD were compared to age, sex matched controls regarding presence H. by serology and urea breath test (UBT). Ongoing was more prevalent among using result UBT odds ratio 3.1 (95% CI: 1.34 – 7.26, PV < 0.001). have the pathogenesis BD.

Rheumatoid arthritis (RA) is a complex disease, the hallmark of which synovial joint inflammation. The substantial contribution from genetic factors in susceptibility to RA has been well-defined. Fc receptor-like3 (FCRL3) gene one genes that have recently shown significant association with RA. To determine possible role FCRL3-169 C/T and FCRL3-110 A/G polymorphisms development Iranian patients, 320 patients 302 healthy subjects were genotyped by polymerase chain reaction-restriction fragment...

Background: Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are chronic complex autoimmune diseases, involving multiple organs. Therefore, quality of life (QoL) in SLE RA patients can be affected. The current study aimed to compare with the healthy population terms health-related QoL (HRQoL) Shiraz, Iran. Methods: present cross sectional, analytical was performed on 100 patients, 200 controls, who were referred rheumatology clinics (Motahari Hafez clinics) Shiraz University...

Behçet's disease is a systemic vasculitis. Mucocutaneous involvement the most prominent finding, but triggering factors are not well-known. We decided to assess beliefs of patients with regarding potential role food, mucosal injury, menstruation, and stress in appearance symptoms. In this cross-sectional study, 60 who fulfilled International Study Group criteria for referred outpatient clinic Motahari, affiliated Shiraz University Medical Sciences, were included. A questionnaire was designed...

Pyoderma gangrenosum (PG) is an uncommon ulcerative cutaneous disease, without any well-known specific and effective treatment. Here we report two patients with severe recalcitrant perineal pyoderma gangrenosum, successfully treated low dose systemic tacrolimus. Tacrolimus can be a safe drug in the management of PG.

Behçet's disease (BD) can negatively impact the quality of life (QoL) affected patients. The present study aimed to assess QoL BD patients using Leeds BD-QoL and compare its results with WHOQOL-BREF questionnaire.In cross-sectional study, 179 304 healthy individuals (the control group) were recruited in Shiraz, 2017. Persian version questionnaires used BD. patient groups was compared after controlling effect some variables (age, sex, marital status, educational level) multiple linear...

The pathergy test (PT) is part of the diagnostic criteria Behçet's disease (BD). Factors like needle character and number punctures can affect sensitivity PT. We tried to compare its positivity using a thinner with without self-saliva in active inactive BD, recurrent aphthous stomatitis (RAS), healthy people.Twenty patients 13 20 RAS, 34 controls underwent 3 types PT: 1 - most recommended 20G dry PT, 2 23G PT self-saliva. accuracy tests between groups were compared.All negative normal group....

The cutaneous lupus erythematosus (CLE) is a common manifestation among systemic (SLE) patients. Malar rash and discoid (DLE) are in the category of acute chronic CLE, respectively. pathogenesis CLE multifactorial, cytokine imbalances contribute to immune dysfunction induction organ damage. Many aspects dysregulation still unclear SLE particular CLE. Therefore, we concurrently measured inflammatory [Tumor necrosis factor-alpha (TNF-α) Interleukin (IL)-6)], T helper (Th)-17 (IL-17 IL-23)...

Abstract Objective: Behçet disease (BD) is a multisystemic inflammatory disorder of unknown aetiology that in some patients will present with thrombosis. However, the mechanism thrombosis unknown. In this study, we investigate correlation between homocystein level BD vascular Patient and methods: One hundred twenty‐three who fullfilled criteria International Study Group for ( n = 77, 62.6% females 46, 37.4% males) were included cross‐sectional study. Patients divided into two groups: 23,...