A5009012699- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Food Allergy and Anaphylaxis Research
- Iron Metabolism and Disorders
- Eosinophilic Esophagitis
- Dermatology and Skin Diseases
- Respiratory and Cough-Related Research
- Tracheal and airway disorders
- Contact Dermatitis and Allergies
- Hemoglobinopathies and Related Disorders
- Esophageal and GI Pathology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Complement system in diseases
- Blood properties and coagulation
- Congenital Diaphragmatic Hernia Studies
- Vitamin D Research Studies
- Immune Cell Function and Interaction
- Genomics, phytochemicals, and oxidative stress
- Erythrocyte Function and Pathophysiology
- Vitamin C and Antioxidants Research
- Hemophilia Treatment and Research
- Glutathione Transferases and Polymorphisms
Hacettepe University
2012-2022
ENT and Allergy
2022
Harvard University
2003-2005
Brigham and Women's Hospital
2003-2005
Boston Children's Hospital
2002
Reactive oxygen species (ROS) are produced by living organisms as a result of normal cellular metabolism and environmental factors, such air pollutants or cigarette smoke. ROS highly reactive molecules can damage cell structures carbohydrates, nucleic acids, lipids, proteins alter their functions. The shift in the balance between oxidants antioxidants favor is termed "oxidative stress." Regulation reducing oxidizing (redox) state critical for viability, activation, proliferation, organ...
Previous genetic studies have associated the region of human genome (14q22.1) containing gene for prostanoid DP receptor (PTGDR) with asthma. A study a mouse model suggests that is required expression asthma phenotype. Our associations functional variants PTGDR link these observations.We identified and evaluated combinations influence transcription disease association in case-control 518 white patients 175 controls 80 black 45 controls.We four novel two previously reported single-nucleotide...
Background: There is ample evidence for the existence of a systemic oxidative stress in childhood asthma but relatively little information on oxidant airways. Objective: To determine extent oxidant/antioxidant imbalance and describe its determinants airways asthmatic children including severity genotype antioxidant enzymes. Methods: One hundred ten with mild asthma, 30 moderate 191 healthy controls were included study. Exhaled breath condensate (EBC) was collected from all EcoScreen ® ....
Background: Endotoxin, with its potential to enhance type 1 immunity, is a significant player in the hygiene hypothesis. The combined effects of genetic variants various molecules endotoxin response pathway on asthma related phenotypes are largely unknown. Objective: To investigate CD14 and TLR4 genes large number asthmatic children. Methods: 613 children were genotyped at ‐C159T, ‐A896G ‐C1196T loci. IgE, eosinophil numbers FEV1 compared 327 who not any controller medications symptom free....
Genetic associations of the response to inhaled corticosteroids (ICSs) during an asthma exacerbation are unknown.To evaluate role genetic variants in therapeutic high-dose ICS children with moderate-to-severe exacerbations.Eighty-two (56 boys/26 girls, mean age 9.6 ± 3.2 years) moderate-severe were genotyped for eight single-nucleotide polymorphisms that a priori associated chronic treatment: glucocorticosteroid receptor (NR3C1) rs41423247; corticotrophin-releasing hormone receptor1 (CRHR1)...
Background: The number of Sp1–Egr1 binding tandem repeats at the ALOX5 promoter influences gene transcription and may modify response to anti‐leukotriene treatment. relationship variants asthma severity leukotriene production by eosinophils is unknown. Objective: To characterize mRNA expression cysteinyl‐leukotriene from individuals bearing deletional their association with childhood asthma. Methods: Eosinophils adult asthmatics only variant alleles (with other than five on both chromosomes,...
<b><i>Background:</i></b> Thymic stromal lymphopoietin (TSLP) is expressed by airway epithelial cells and plays a key role in immunological events asthma. Data on the genetic variants of TSLP its association with asthma allergic rhinitis are scarce. We aimed to investigate effects children rhinitis. <b><i>Methods:</i></b> The gene were determined sequencing 25 asthmatic healthy children. In an study, population 506 asthmatics 157 controls was...
Indoleamine 2,3-dioxygenase (IDO), which degrades tryptophan (Trp) to kynurenine (Kyn), has been demonstrated contribute modulation of allergic responses. However, the role IDO in food allergy not yet elucidated.Serum Trp and Kyn concentrations were analyzed by high-pressure liquid chromatography. Expression gene was measured real-time PCR. The levels interleukin (IL)-4, IL-10, interferon (IFN)-γ cell culture supernatants ELISA.Kyn/Trp (IDO activity) significantly lower subjects with (n =...
Background: Several markers that influence the clinical course of atopic dermatitis (AD) have been investigated so far. Thymus and activation regulated chemokine (TARC) – a Th2-related cytokine increase in various diseases. It has shown vitamin D affects Treg cells immune responses. Zinc as an essential trace element for cell–cell interactions, cellular differentiation, proliferation. However, effect these on infantile AD disease severity are mostly unknown.Objective: The aim this study was...
Even though the genotype at promoter region of CD14 molecule is known to affect atopic phenotypes, cellular and molecular basis this association largely unknown.To investigate effect lipopolysaccharide (LPS) on IgE production cytokine profile by peripheral blood mononuclear cells (PBMC) obtained from asthmatic children with TT CC genotypes position -159 gene.Peripheral alternative C159T locus were stimulated 2 200 ng/ml LPS in vitro. The IgE, IgG and, IgM response was determined ELISA Ig...
<i>Background:</i> The aspirin provocation test, considered to be the gold standard in diagnosis of sensitivity, may associated with severe adverse reactions; thus, alternative procedures a higher safety profile are highly desirable. Although cellular antigen stimulation test (CAST) has been proposed such an alternative, there is limited information about its clinical usefulness. <i>Objective:</i> It was aim our study evaluate usefulness CAST sensitivity....
Pistachio and cashew nut, which belong to the same botanical family, are tree nuts that induce serious allergic reactions.We aimed determine predictive factors for pistachio nut reactivity during oral food challenge (OFC).A total of 112 and/or sensitized children, aged 58.45 (IQR:40.38-88.32) months, were included. Cutoff values probability curves skin prick test (SPT), sIgE, sIgE/Total IgE predict determined nut. Additionally, a diagram was created can be useful while making decision OFC...
Background Genetic variants in endotoxin signaling pathway are important modulating the effect of environmental on asthma and atopic phenotypes. Our objective was to determine single nucleotide polymorphisms (SNPs) that may influence vitro IgE synthesis investigate relationship between these exposure relation development atopy a birth cohort. Methods Peripheral blood mononuclear cells from 45 children with were stimulated 2 200 ng/ml lipopolysaccharide measured culture supernatants. Children...