A5037309130- Genetic and phenotypic traits in livestock
- Animal Genetics and Reproduction
- Genetic Mapping and Diversity in Plants and Animals
- Human-Animal Interaction Studies
- Veterinary Equine Medical Research
- RNA modifications and cancer
- Identification and Quantification in Food
- Cancer-related molecular mechanisms research
- Genetic diversity and population structure
- Toxoplasma gondii Research Studies
- Hemophilia Treatment and Research
- Biochemical Analysis and Sensing Techniques
- Poverty, Education, and Child Welfare
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Ruminant Nutrition and Digestive Physiology
- CRISPR and Genetic Engineering
- Child Nutrition and Feeding Issues
- melanin and skin pigmentation
- Morphological variations and asymmetry
- T-cell and Retrovirus Studies
- Cancer-related gene regulation
- Meat and Animal Product Quality
- Child Abuse and Trauma
- Molecular Biology Techniques and Applications
Amazon (United States)
2020
Cornell University
2009-2018
New York State College of Veterinary Medicine
2018
Centre National de la Recherche Scientifique
2014
Institut Pasteur
2014
Columbia University
2011
Horse body size varies greatly due to intense selection within each breed. American Miniatures are less than one meter tall at the withers while Shires and Percherons can exceed two meters. The genetic basis for this variation is not known. We hypothesize that breed population structure of horse should simplify efforts identify genes controlling size. In support this, here we show with genome-wide association scans (GWAS) just four loci explain great majority variation. Unlike humans, which...
Summary Horses, like many domesticated species, have been selected for broad variation in skeletal size. This is not only an interesting model of rapid evolutionary change during domestication, but also directly applicable to the horse industry. Breeders select complex traits body size and conformation improve marketability, function, soundness performance show ring. Using a well‐defined set 35 measurements, we identified quantified species. We collected measurements from 1215 horses...
Inbreeding depression has been demonstrated to impact vital rates, productivity, and performance in human populations, wild endangered species, recent years, the domestic species. In all cases, standardized, high-quality phenotype data on individuals are invaluable for longitudinal analyses such as those required evaluate rates of a study cohort. Further, many investigators agree upon preference utility genomic measures inbreeding lieu pedigree-based estimates inbreeding. We evaluated...
Consumer genomics enables genetic discovery on an unprecedented scale by linking very large databases of personal genomic data with phenotype information voluntarily submitted via web-based surveys. These are having a transformative effect human research, yielding insights increasingly complex traits, behaviors, and disease including many thousands individuals in genome-wide association studies (GWAS). The promise consumer is not limited to however. Genomic tools for dogs readily available,...
Random X-chromosome inactivation ensures dosage compensation in mammals through the transcriptional silencing of one two X chromosomes present each female cell. Silencing is initiated differentiating epiblast mouse embryos coating nascent inactive chromosome by non-coding RNA Xist, which subsequently recruits Polycomb Complex PRC2 leading to histone H3-K27 methylation. Here we examined ES cells early steps transition from naive towards stem as a model for inducing vitro. We show that these...
Summary Consumer genomics enables genetic discovery on an unprecedented scale by linking very large databases of personal genomic data with phenotype information voluntarily submitted via web-based surveys 1 . These are having a transformative effect human research, yielding insights increasingly complex traits, behaviors, and disease including many thousands individuals in genome-wide association studies (GWAS) 2, 3 The promise consumer is not limited to however. Genomic tools for dogs...
Structural variations (SVs) represent a large fraction of all genetic diversity, but how this diversity is translated into phenotypic and organismal unclear. Explosive diversification dog coat color patterns after domestication can provide unique opportunity to explore question; however, the major obstacle efficiently collect sufficient number individuals with known phenotypes genotypes hundreds thousands markers. Using customer-provided information about dogs tested on commercial canine...
ABSTRACT Inbreeding depression has been demonstrated to impact vital rates, productivity, and performance in many domestic species. Many the field have value of genomic measures inbreeding compared pedigree-based estimates inbreeding; further, standardized, high-quality phenotype data on all individuals is invaluable for longitudinal analyses a study cohort. We reproductive fitness small cohort Golden Retrievers enrolled Retriever Lifetime Study (GRLS) measurement inbreeding, F ROH ....
ABSTRACT Long noncoding RNAs (lncRNAs) have garnered much attention as possible links between DNA sequence and the protein factors that mediate methylation. However, mechanisms by which methylation is directed to specific genomic locations remain poorly understood. We previously identified a lncRNA in mouse, pitRNA, was implicated control of at imprinted Rasgrf1 locus. The pitRNA transcribed developing male germline antisense differentially methylated region (DMR) harbors paternal allele...
Abstract A male mixed breed dog with clinical Hemophilia B was tested a direct-to-consumer genomics service. After being genotyped as “normal” at three previously published variants, all coding regions of the dog’s F9 gene were sequenced. single basepair deletion in exon 5 led to frameshift mutation leading premature truncation FIX, including loss catalytic domain. The dam for this individual is Great Pyrenees suggesting X chromosome variant could segregate within and possibly related...