A5018346052- Pulmonary Hypertension Research and Treatments
- Pain Mechanisms and Treatments
- Adenosine and Purinergic Signaling
- Cardiovascular Function and Risk Factors
- Nitric Oxide and Endothelin Effects
- Protein Tyrosine Phosphatases
- Heart Failure Treatment and Management
- Mesenchymal stem cell research
- Cardiovascular Issues in Pregnancy
- Cardiac electrophysiology and arrhythmias
- Vagus Nerve Stimulation Research
- Hormonal Regulation and Hypertension
- PI3K/AKT/mTOR signaling in cancer
- Estrogen and related hormone effects
- Cholinesterase and Neurodegenerative Diseases
- Cardiac Ischemia and Reperfusion
- Eicosanoids and Hypertension Pharmacology
- Computational Drug Discovery Methods
- MicroRNA in disease regulation
- Congenital heart defects research
- Nicotinic Acetylcholine Receptors Study
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Fibrosis and Remodeling
- Treatment of Major Depression
- Neurological Complications and Syndromes
Universidade Federal do Rio de Janeiro
2014-2025
Universidade Federal do Estado do Rio de Janeiro
2018-2023
Introduction The current drug discovery paradigm of 'one drug, multiple targets' has gained attention from both the academic medicinal chemistry community and pharmaceutical industry. This is in response to urgent need for effective agents treat multifactorial chronic diseases. molecular hybridization strategy a useful tool that been widely explored, particularly last two decades, design multi-target drugs.
Introduction: Diabetes mellitus (DM) has become a public health problem, which is associated with high morbidity and mortality, due to the chronic complications, such as diabetic neuropathy. Current recommendations for treatment of neuropathic pain achieve reduction 30% in only cases. Therefore, it necessary identify new therapeutic approaches improve quality life patients. Methods: This work evaluated antinociceptive effect intranasal administration combination dextro-ketamine (keta),...
Pulmonary arterial hypertension (PAH) is characterized by enhanced pulmonary vascular resistance, right ventricular hypertrophy and increased systolic pressure. Here, we investigated the effects of a N-acylhydrazone derivative, 3,4-dimethoxyphenyl-N-methyl-benzoylhydrazide (LASSBio-1359), on monocrotaline (MCT)-induced in rats.PAH was induced male Wistar rats single i.p. injection MCT (60 mg·kg(-1)) 2 weeks later, oral LASSBio-1359 (50 or vehicle given once daily for 14 days....
Aims: Pulmonary arterial hypertension (PAH) is a disease characterized by an increase in pulmonary vascular resistance and right ventricular (RV) failure. We aimed to determine the effects of human mesenchymal stem cell (hMSC) therapy SU5416/hypoxia (SuH) mice model PAH. Methods Results: C57BL/6 (20-25 g) were exposure 4 weeks hypoxia combined endothelial growth factor receptor antagonism (20 mg/kg SU5416; weekly s.c. injections; PAH mice). Control housed room air. Following 2 SuH exposure,...
Pulmonary hypertension (PH) is a disease of women (female-to-male ratio 4:1), and associated with cardiac skeletal muscle dysfunction. Herein, the activation new estrogen receptor (GPER) by agonist G1 was evaluated in oophorectomized rats monocrotaline (MCT)-induced PH. Depletion induced bilateral oophorectomy (OVX) Wistar rats. Experimental groups included SHAM or OVX that received single intraperitoneal injection MCT (60 mg/kg) for PH induction. Animals s.c. either vehicle G1, GPER...
Rheumatoid arthritis is an inflammatory autoimmune condition, and tumor necrosis factor-α (TNF-α) plays important role in its pathophysiology. In vitro, (E)-N'-(3,4-dimethoxybenzylidene)-N-methylbenzohydrazide (LASSBio-1359) has exhibited anti-TNF-α properties, vivo these effects are mediated via activation of adenosine receptor. This work investigates the antinociceptive action LASSBio-1359 murine models acute chronic pain. Male mice received intraperitoneal injection then were evaluated...
Cerebral cavernous malformations (CCM) are developmental venous dysplasias which present as abnormally dilated blood vessels occurring mainly in the brain. Alterations vascular biology originate from somatic mutations genes regulating angiogenesis and endothelial-to-mesenchymal transition. Vascular lesions may occur at any time develop silently, remaining asymptomatic for years. However, symptomatic disease is often debilitating, patients prone to drug-resistant epilepsy hemorrhages. There...
Resumo Fundamento A hipertensão arterial sistêmica é um fator de risco para disfunções cardíacas, renais e metabólicas. busca por novas estratégias prevenir tratar doenças cardiovasculares levou à síntese N-acilidrazonas produzir efeito anti-hipertensivo. Os receptores adenosina são alvo alternativo reduzir a pressão devido sua ação vasodilatadora propriedades antioxidantes, que podem o estresse oxidativo característico da sistêmica. Objetivo Avaliar perfil anti-hipertensivo novos compostos...
Endemic and pandemic viruses represent significant public health challenges, leading to substantial morbidity mortality over time. The COVID-19 has underscored the urgent need for development discovery of new, potent antiviral agents. In this study, we present synthesis anti-SARS-CoV-2 activity a series benzocarbazoledinones, assessed using cell-based screening assays. Our results indicate that four compounds (4a, 4b, 4d, 4i) exhibit EC50 values below 4 μM without cytotoxic effects in Calu-3...
Mitogen-activated protein kinase (MAPK) signaling is strongly implicated in cardiovascular remodeling pulmonary hypertension (PH) and right ventricle (RV) failure. The effects of a newly designed p38 inhibitor, LASSBio-1824, were investigated experimentally induced PH. Male Wistar rats exposed to hypoxia SU5416 (SuHx), normoxic used as controls. Oral treatment was performed for 14 days with either vehicle or LASSBio-1824 (50 mg/kg). Pulmonary vascular resistance RV structure function...
Diabetic obese patients are susceptible to the development of cardiovascular disease, including hypertension and cardiac dysfunction culminating in diabetic cardiomyopathy (DC), which represents a life-threatening health problem with increased rates morbidity mortality. The aim study is characterize effects new benzofuran N-acylhydrazone compound, LASSBio-2090, on metabolic alterations Zucker fatty (ZDF) rats presenting DC.Male non-diabetic lean (ZL) ZDF treated vehicle (dimethylsulfoxide)...
New therapeutic alternatives for pain relief include the use of phosphodiesterase-5 (PDE5) inhibitors, which could prevent transmission painful stimuli by neuron hyperpolarization via nitric oxide (NO)/cyclic 3',5'-guanosine monophosphate (cGMP) pathway. The present work investigated antinociceptive activity a new PDE5 inhibitor, lodenafil carbonate, in inflammatory and neuropathic models.Although no effect was detected on neurogenic phase formalin test mice, oral administration carbonate...
Pulmonary arterial hypertension (PAH) is characterized by the remodeling of pulmonary arteries, with an increased pressure and right ventricle (RV) overload. This work investigated benefit association human umbilical cord mesenchymal stem cells (hMSCs) lodenafil, a phosphodiesterase-5 inhibitor, in animal model PAH. Male Wistar rats were exposed to hypoxia (10% O2) for three weeks plus weekly i.p. injection vascular endothelial growth factor receptor inhibitor (SU5416, 20 mg/kg, SuHx). After...
Heart failure with preserved ejection fraction (HFpEF) observed in women estrogen depletion is a consequence of the reduction cardioprotection and endothelial dysfunction. Rho-kinase (ROCK) signaling pathway plays role cardiac dysfunction consequent to female aging. This work investigated effects new synthetic ROCK inhibitor (iROCK) after oral administration spontaneously hypertensive rats (SHR) submitted oophorectomy (OVX). Experimental protocols were approved Animal Care Use Committee at...
Current treatments for acute myocardial infarction (AMI) include pain relief and attempts to improve survival. This study investigated the effects of two new ligands adenosine receptor, LASSBio-1027 LASSBio-1860, on cardiac function in an experimental model AMI.
In advanced age, women tend to develop heart failure with preserved ejection fraction (HFpEF) due estrogen depletion. The signaling pathway of ROCK is involved in cardiac complications consequent female aging. Thus, this work investigated the comparative effects atorvastatin and inhibitor, fasudil on treatment HFpEF induced by oophorectomy (OVX) spontaneously hypertensive rats (SHR). Protocols were approved Animal Care Use Committee at Universidade Federal do Rio de Janeiro. Under anesthesia...