A5044989957- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Peroxisome Proliferator-Activated Receptors
- Heart Failure Treatment and Management
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
National Cancer Institute
2016-2018
The University of Texas MD Anderson Cancer Center
2018
National Institutes of Health
2018
Medical College of Wisconsin
2015
Mayo Clinic
2015
University of Oslo
2015
Oslo University Hospital
2015
Institutt for Eksperimentell Medisinsk Forskning
2015
Columbia University
1998
Cancer recurrence after initial diagnosis and treatment is a major cause of breast cancer (BC) mortality, which results from the metastatic outbreak dormant tumour cells. Alterations in microenvironment can trigger signalling pathways cells leading to their proliferation. However, processes involved long-term survival disseminated BC remain largely unknown. Here we show that autophagy critical mechanism for Pharmacologic or genetic inhibition significantly decreased cell burden mouse human...
The standard treatment for high-grade serous ovarian cancer is primary debulking surgery followed by chemotherapy. extent of metastasis and invasive potential lesions can influence the outcome these surgeries. Here, we explored underlying mechanisms that could increase metastatic in cancer. We discovered FABP4 (fatty acid binding protein) substantially cells. also found miR-409-3p regulates cells hypoxia decreases levels. Treatment with DOPC nanoliposomes containing either mimic or siRNA...
Altered myocardial structure and function, secondary to chronically elevated blood pressure, are leading causes of heart failure death. B-type natriuretic peptide (BNP), a guanylyl cyclase A agonist, is cardiac hormone integral cardiovascular regulation. Studies have demonstrated causal relationship between reduced production or impaired BNP release the development human hypertension. However, consequences insufficiency on pressure hypertension-associated complications remain poorly...
Abstract Tumor cells disseminate from the primary tumor site early in disease process. These disseminated may remain dormant for years and later become proliferative to cause clinical recurrence morbidity. The goal of this study is better understand biological genetic mechanisms driving switch. We have developed a 3D culture system using murine mammary cell line, D2.0R. D2.0R when cultured on basement membrane extract (BME), exit dormancy supplemented with collagen-1 (col-1). characterized...
Abstract Cancer recurrence resulting from the metastatic outbreak of dormant disseminated tumor cells following apparent successful treatment primary is a major cause breast cancer mortality. However, little known regarding molecular mechanisms governing tumour cell dormancy and dormant-to-proliferative switch, impeding development effective therapeutic strategies. We therefore investigated whether stress-induced autophagy may promote survival and, consequently, inhibition could prevent...