A5073249909- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Hedgehog Signaling Pathway Studies
- Metabolism, Diabetes, and Cancer
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Multiple Myeloma Research and Treatments
- Inflammasome and immune disorders
- TGF-β signaling in diseases
- Fatty Acid Research and Health
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- Chromatin Remodeling and Cancer
- Immune cells in cancer
University of Illinois Chicago
2018-2024
University of Chicago
2023-2024
The fibrotic reaction is a characteristic feature of human pancreatic ductal adenocarcinoma (PDAC) tumors. It associated with activation and proliferation stellate cells (PSCs), which are key regulators fibrosis in vivo. While there increasing interest the regulation PD-L1 expression cancer immune cells, other stromal such as PSCs, has not been fully evaluated. Here we show that PSCs vitro express higher mRNA protein levels compared to present PDAC cells. We inhibitors targeting bromodomain...
Significance Although activation of PI3K p110α appears to promote pancreatic cancer development via canonical AKT signaling, in the setting a high-fat diet (enriched ω−6 fatty acids), unopposed p110γ inhibition poses risk for severe hepatic damage. Considering that obesity is factor cancer, these observations suggest need caution when translating drugs targeting clinic.
Abstract Pancreatic ductal adenocarcinoma (PDAC) has extensive stromal involvement and remains one of the cancers with highest mortality rates. Activin A been implicated in colon cancer its stroma but role PDAC not elucidated. expression was assessed human tissue microarrays (TMA). TMA is significantly higher samples, correlated shorter survival. Cultured pancreatic stellate cells (PSC) were found to secrete high levels activin resulting cell migration that abolished by anti-activin...
Current therapies for pancreatic ductal adenocarcinoma (PDAC) only modestly impact survival and can be highly toxic. A greater understanding of the molecules regulating this disease is critical identifying new drug targets developing more effective therapies. The L6 family proteins are known to positive regulators tumor growth metastasis among various cancers. However, little about member TM4SF18. We investigated expression localization TM4SF18 protein in normal human pancreas PDAC tissue....
Immune-based therapies induce durable remissions in subsets of patients across multiple malignancies. However, there is limited efficacy immunotherapy metastatic castrate-resistant prostate cancer (mCRPC), manifested by an enrichment immunosuppressive (M2) tumor- associated macrophages (TAM) the tumor immune microenvironment (TME). Therefore, therapeutic strategies to overcome TAM-mediated immunosuppression are critically needed mCRPC. Here we discovered that NLR family pyrin domain...
Abstract Immune-based therapies induce durable remissions in subsets of patients across multiple malignancies. However, there is limited efficacy immunotherapy metastatic castrate-resistant prostate cancer (mCRPC), manifested by an enrichment immunosuppressive (M2) tumor-associated macrophages (TAM) the tumor immune microenvironment (TME). Therefore, therapeutic strategies to overcome TAM-mediated immunosuppression are critically needed mCRPC. Our single-cell RNA sequencing analysis human...
Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the worst solid malignancies in regard to outcomes and metabolic dysfunction leading cachexia. It alarming that PDAC incidence rates continue increase warrant need for innovative approaches combat this disease. Due its relatively slow progression (10–20 years), prevention strategies represent an effective means improve outcomes. One risk factors many cancers pancreatic cancer particular diet. Hence, our objective understand how a...
Abstract A hallmark feature of pancreatic cancer is a dense fibrotic stroma that surrounds the tumor and sequesters blood vessel growth. The lack vessels results in poor perfusion, causing most therapies to fail. Antistromal therapy via targeting sonic hedgehog (SHH) pathway controversial approach improving drug distribution for cancer. While this has been shown be initially effective, over time depletion return an aggressive Long-term stromal creates microenvironment permits angiogenesis...
Abstract Pancreatic cancer (PC) is one of the few cancers for which incidence and mortality continue to rise despite increasing knowledge its etiology risk factors. Amongst latter, dietary patterns are significantly associated with PC risk. Due relatively slow progression, preventive strategies represent a simple means improve outcomes. We interested in understanding influence diet on prevention have studied effects polyunsaturated fatty acids (PUFAs) progression disease both vitro (via cell...