A5015240820- Sexual Differentiation and Disorders
- Hormonal Regulation and Hypertension
- Hormonal and reproductive studies
- Ovarian function and disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- COVID-19 Clinical Research Studies
- Metabolism and Genetic Disorders
- Adrenal Hormones and Disorders
- SARS-CoV-2 and COVID-19 Research
- Stress Responses and Cortisol
- Reproductive Biology and Fertility
- Ultrasound and Hyperthermia Applications
- Genomic variations and chromosomal abnormalities
- Genetics and Neurodevelopmental Disorders
- Liver Disease Diagnosis and Treatment
- Antioxidant Activity and Oxidative Stress
- Retinoids in leukemia and cellular processes
- Ancient Near East History
- Oral Health Pathology and Treatment
- Blood properties and coagulation
- Blood Coagulation and Thrombosis Mechanisms
- Chromatin Remodeling and Cancer
- Disaster Response and Management
- Inflammasome and immune disorders
- Plant responses to elevated CO2
Erzincan University
2017-2024
Erciyes University
2011-2020
Background Congenital adrenal hyperplasia (CAH) is one of the most common autosomal recessive inherited endocrine diseases. Steroid 11β-hydroxylase (P450c11) deficiency (11OHD) second form CAH. Aim The aim study was to functional consequences three novel CYP11B1 gene mutations (p.His125Thrfs*8, p.Leu463_Leu464dup and p.Ser150Leu) detected in patients suffering from 11OHD correlate this data with clinical phenotype. Methods Functional analyses were done by using a HEK293 cell vitro expression...
Testicular adrenal rest tumors (TART) occur frequently in adolescents and adults with 21-hydroxylase deficiency. There have been no reports of TART children 3β-hydroxysteroid dehydrogenase deficiency (HSD3β). Biopsy proven was diagnosed a 31/12-year-old male patient also his 22-month-old sibling. Hormonal anthropometric measurements were performed during glucocorticoid fludrocortisone treatment. The mutational analysis by direct DNA sequencing the complete coding region HSD3β2 gene....
Introduction Polycystic ovary syndrome (PCOS) is one of the most common endocrine–reproductive–metabolic disorders women at reproductive age. Many investigations have revealed that reactive oxygen species (ROS) level significantly increased in patients with PCOS compared to healthy women.Object The goal current study investigate association between superoxide dismutase (SOD) variants and risk among Turkish women.Method subjects Three hundred twelve voluntary premenopausal (148 controls 164...
Aim of this work was to determine the effects dietary intake vitamin E and Se on lipid peroxidation (LPO) as Thiobarbituric acid reactive substances (TBARS) antioxidative defense mechanisms in heart tissues rats treated with high doses prednisolone. 250 adult male Wistar were randomly divided into 5 groups fed normal diet. Additionally 3, 4, received a daily supplement their drinking water 20 mg E, 0.3 Se, combination (20 mg/ mg), respectively, for 30 days. For 3 d subsequently, control...
Topical steroids (TS) have been widely prescribed since the 1950s. This study investigated for first time transgenerational effects of TS on antioxidant mechanism hypothalamus-pituitary-adrenal (HPA) axis, both in prenatal and infancy. Three generations (F1, F2, F3) group (P) were sexes with two different points; P45th P75th day accepted as puberty early adulthood, respectively. Clobetasol propionate 0.05% was used TS. Quantitative real-time PCR performed to expressional analyses Sod1, Sod2,...
Objective: The study aimed to analyze the association between coronavirus disease-2019 (COVID-19) disease severity and genetic susceptibility in pregnant women. Material Methods: research included 54 women with confirmed COVID-19 diagnosis. All volunteers were evaluated physically biochemically. Angiotensin-converting enzyme (ACE)2 (p.T27A A>G, p.G326E G>A, p.K419T A>C, ACE (p.T776T g.16471_16472delinsALU (I/D), AGTR1 c.*86A>C, methylenetetrahydrofolate-reductase (MTHFR) p.A222V C>T...
Objective It is necessary to identify appropriate clinical, biochemical, epidemiological and genetic biomarkers elucidate the underlying mechanisms of coronavirus disease-2019 (COVID-19) disease. The study focused on not only link between disease severity (non-intense unit care (non-ICU) versus intensive (ICU) susceptibility in COVID-19 patients but also connection comorbidity affecting COVID-19.
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)