A5000760045- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular and Diving-Related Complications
- Heat shock proteins research
- Carbohydrate Chemistry and Synthesis
- Cardiac Arrhythmias and Treatments
- Hepatitis C virus research
- Antiplatelet Therapy and Cardiovascular Diseases
- RNA modifications and cancer
- Biomedical and Engineering Education
- Hepatitis B Virus Studies
- Viral gastroenteritis research and epidemiology
- Toxin Mechanisms and Immunotoxins
- Acute Myocardial Infarction Research
- Health and Conflict Studies
- Cancer, Hypoxia, and Metabolism
- Advanced Proteomics Techniques and Applications
- Nutrition, Genetics, and Disease
- Retinoids in leukemia and cellular processes
- Protein Tyrosine Phosphatases
- COVID-19 diagnosis using AI
- Lysosomal Storage Disorders Research
- Cardiac Imaging and Diagnostics
University of Zagreb
2007-2022
Sisters of Charity Hospital
2021
In certain clinical situations, it is necessary to determine whether clinically relevant plasma levels of direct oral anticoagulants (DOACs) are present. We examined qualitative testing DOACs in urine samples can exclude DOAC concentrations ≥30 ng/mL. This prospective single-center cohort study included consecutive patients treated with an factor Xa inhibitor (DXI) (apixaban, n = 31, rivaroxaban, 53) and thrombin (DTI) (dabigatran, 44). aimed define the negative predictive value (NPV) other...
Protein glycosylation is the most common epiproteomic modification involved in numerous physiological and pathological processes. Previous studies reported strong associations between human plasma N-glycans age, prompting us to evaluate potential application of this biological phenomenon field forensics. Blood from 526 blood donors different parts Croatia was collected on bloodstain cards during period 2004-2007 stored at 4°C for 6-9 years. Glycosylation profiles bloodstains were analysed...
Clinical application of rivaroxaban and apixaban does not require therapeutic monitoring. Commercial anti-activated factor X (anti-FXa) inhibition methods for all anti-FXa drugs are based on the same principle, so there attempts to evaluate potential clinical heparin-calibrated assay as an alternative method direct FXa inhibitors. We aimed relationship between calibrated with low molecular weight heparin (LMWH) drug specific calibrators, determine whether commercial LMWH can be used exclude...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological tests have been suggested as an additional diagnostic tool in highly suspected cases with a negative molecular test and determination of seroprevalence population. We compared the performance eight commercial assays for IgA, IgM, IgG antibodies to SARS-CoV-2 virus.The comparison study was performed on total 76 serum samples: 30 polymerase chain reaction (PCR)-negative 46 PCR-positive patients asymptomatic severe disease...
Recreational SCUBA (rSCUBA) diving has become a highly popular and widespread sport. Yet, information on molecular events underlying (patho)physiological that follow exposure to the specific environmental conditions (hyperbaric conditions, coldness, immersion, elevated breathing pressure), in which rSCUBA is performed, remain largely unknown. Our previous study suggested repeated triggers an adaptive response of cardiovascular immune system. To elucidate further cardiac system adaptation...
Abstract To understand better the adaptation response of cardiovascular system (CVS) to self-contained underwater breathing apparatus (SCUBA) diving, Galectin-3 (Gal-3) and specific CVS biomarkers were measured in plasma 16 male recreational divers before after (30 min, 3 6 h) diving (total time 30 min at m depth) undertaken a long non-dive period. The one-time SCUBA dive caused significant increase Gal-3, N-terminal prohormone brain natriuretic peptide (NT-proBNP), high-sensitivity...
It has been shown that one recreational SCUBA (rSCUBA) diving session is sufficient to cause changes in plasma level of cardiovascular (CV) and muscular biomarkers. To explore whether repetitive rSCUBA triggers an adaptive response the CV, muscular, immune system, we measured cardiac damage (NT-proBNP, hs-TnI, CK-MB), muscle (myoglobin (Mb), galectin-3, CK, LDH), vascular endothelial activation (ET-1 VEGF), inflammatory (leukocyte count (Lkc), CRP, IL-6) A longitudinal intervention study...
Background : Gilbert's syndrome is a chronic or recurrent mild unconjugated hyperbilirubinemia caused by decreased activity of UDP glucuronosyltranferase ( UGT1A1 ). The most common cause in Caucasians homozygous variant the A(TA) 7 TAA promoter polymorphism. Alleles with five eight TA repeats have also been described, but they are very rare Caucasian populations. Methods Over 6-year period (2001–2006), 1109 subjects suspected were included this study. Genotyping (TA) 6 and alleles was...
The congenital disorder of glycosylation (CDG)-Ic (ALG6-CDG, CDG-Ic) is caused by mutations in the hALG6 gene that encodes N-glycosylation pathway enzyme, α-1,3-glucosyltransferase (NP_037471.2). aim our study was to estimate frequencies ALG6-CDG related p.Y131H and p.F304S polymorphisms Croatian population. Genomic DNA isolated from blood samples collected 600 healthy individuals. Functional single-nucleotide rs35383149 rs17856039 causing p.F304S, respectively, were genotyped TaqMan method...
Abstract Congenital disorder of glycosylation type Ic (CDG‐Ic) is caused by mutations in h ALG6 gene encoding α‐1,3 glucosyltransferase (NP_037471.2), an enzyme that catalyzes the addition first glucose residue to growing lipid‐linked oligosaccharide precursor N‐glycosylation process. The most frequent mutation causing CDG‐Ic c.998C>T results p.A333V substitution. Up‐to‐date, no patient has been detected Croatia. However, as a part comprehensive project undertaken with aim estimate...