A5100756842- Genetic factors in colorectal cancer
- Thyroid Disorders and Treatments
- Asthma and respiratory diseases
- Genetic Associations and Epidemiology
- Health Promotion and Cardiovascular Prevention
- Metabolism, Diabetes, and Cancer
- Methane Hydrates and Related Phenomena
- Pediatric health and respiratory diseases
- Microbial Community Ecology and Physiology
- Prostate Cancer Treatment and Research
- Colorectal Cancer Screening and Detection
- Stress Responses and Cortisol
- Cholinesterase and Neurodegenerative Diseases
- Cancer, Hypoxia, and Metabolism
- Family and Patient Care in Intensive Care Units
- Neuropeptides and Animal Physiology
- Vitamin D Research Studies
- Acute Ischemic Stroke Management
- BRCA gene mutations in cancer
- Appendicitis Diagnosis and Management
- Polar Research and Ecology
- PI3K/AKT/mTOR signaling in cancer
- Immune Response and Inflammation
- Coastal wetland ecosystem dynamics
- Spaceflight effects on biology
Qinghai Normal University
2025
State Forestry and Grassland Administration
2025
Tianjin Chest Hospital
2021
Chongqing Medical University
2020-2021
Harvard University
1998-2020
Brigham and Women's Hospital
1998-2020
XinHua Hospital
2020
Tongji University
2019
Emory University
2017
Hebei Provincial Center for Disease Control and Prevention
2009-2013
Global climate change has accelerated the reduction of permafrost regions across different altitude gradients, shortening duration freezing period to varying extents. However, response soil microorganisms frozen soils along gradients remains unclear. In this study, we employed 16S rRNA sequencing and LC-MS metabolomics investigate microbial communities metabolites vertical stratification in Qinghai Lake region. The results indicated that Proteobacteria, Firmicutes, Actinobacteria were key...
Two recent genome-wide association studies have independently identified a prostate cancer susceptibility locus on chromosome 10q11.2. The most significant single-nucleotide polymorphism (SNP) marker reported, rs10993994, is 57 bp centromeric of the first exon MSMB gene, which encodes beta-microseminoprotein (prostatic secretory protein 94). In this study, fine-mapping analysis using HapMap SNPs was conducted across approximately 65-kb region (chr10: 51168330-51234020) flanking rs10993994...
Background Managing risk factors is crucial to prevent stroke. However, few cohort studies have evaluated socioeconomic together with conventional affecting incident stroke and its subtypes in China. Methods Results A 2014 2016 prospective study from the China National Stroke Screening Intervention Program comprised 437 318 adults aged ≥40 years without at baseline. There were 2429 cases of first‐ever during a median follow‐up period 2.1 years, including 2206 ischemic strokes 237 hemorrhagic...
Streptococcus pneumoniae is a pathogen that causes serious respiratory disease and meningitis in the immunocompromised drug abuse population. However, precise mechanisms by which compromises host immune defense to pulmonary S. infection not fully understood. Using well-established murine model of opiate lung infection, we explored influence morphine treatment on interleukin-23 (IL-23)/IL-17 axis related innate immunity. Impairment early IL-23/IL-17 production caused was associated with...
Precipitation change strongly influences soil microbial communities, and precipitation patterns have become a key factor affecting carbon nitrogen cycling processes in wetland ecosystems. The cbbL gene is the fixation of dioxide during Calvin cycle. However, response cbbL-carrier carbon-fixing microorganisms lakeshore to remains unclear. To this end, we established 25% 50% increased decreased treatments, along with natural control, used high-throughput sequencing investigate community...
Allergic asthma is a typical chronic inflammatory disease of respiratory tract. Clinical data shows that patients with allergic have different degrees cognitive dysfunction. The molecular mechanism underlying the pathogenesis asthma-induced disorder not yet well defined. Dexamethasone (DEX), one first-line drugs being widely used in treatment asthma, has been reported to an effect on dysfunction mice model. To investigate impairment as DEX asthma-caused morphological and behavioral changes,...
The aim of the present study was to estimate lifetime health and economic effects different strategies caring for diabetic foot in Chinese setting. A mathematical model developed simulate onset progression disease patients with type 2 diabetes managed optimal care usual care. Clinical utility data were obtained from published literature. Direct medical costs resource utilization healthcare setting considered. Sensitivity analyses undertaken test a range variables assumptions on results....
Cyclin D1 (CCND1) plays a key role in cell cycle control, particularly the transition from G1 to S phase, which is regulated by cyclin-dependent kinases. A common adenine guanine polymorphism (A870G) CCND1 gene has been associated with longer-life protein and an increased risk of colorectal cancer adenoma some studies. Among subjects hereditary nonpolyposis cancer, A870G also younger age onset cancer. We analysed 181 cases 475 matched controls 524 517 within women Nurses’ Health Study (NHS)...
Abstract Background The present study was designed to investigate the protective effects and mechanisms of carnosine on lipopolysaccharide (LPS)-induced injury in Caenorhabditis elegans . Methods C. individuals were stimulated for 24 h with LPS (100 μg/mL), or without (0.1, 1, 10 mM). survival rates behaviors determined. activities superoxide dismutase (SOD), glutathione reductase (GR), catalase (CAT) levels malondialdehyde (MDA) (GSH) determined using respective kits. Reverse transcription...
Background: Studies have suggested that cognitive impairment in Alzheimer’s disease (AD) is associated with dendritic spine loss, especially the hippocampus. Fluoxetine (FLX) has been shown to improve cognition early stage of AD and be diminishing synapse degeneration However, little known about whether FLX affects pathogenesis middle-tolate its effects are correlated amelioration hippocampal dysfunction. Previously, it observed improves spatial learning ability middleaged APP/PS1 mice....
To investigate the long-term economic outcome of dapagliflozin versus metformin in Chinese patients with type 2 diabetes mellitus (T2DM) whose diet and exercise have not provided sufficient glycemic control.An analysis was conducted by using Outcomes Model for T2DM a time horizon lifetime, which developed validated based on population. The efficacy data lowering HbA1c derived from network meta-analysis. Other clinical, cost utility inputs were obtained published sources. Lifetime discounted...
Type 2 diabetes mellitus (T2DM) is a health challenge in China, and the economic outcomes of lifestyle intervention are critically important for policymakers. This study estimates lifetime among prediabetic population Chinese context. We developed mathematical model to compare cost-effectiveness no prevention population. Efficacy safety, medical expenditure, utility data were derived from literature, which was assigned variables estimating quality-adjusted life-years (QALYs) costs as well...
Objective To investigate the supply of iodized salt in non-excessive iodine counties and iodine-free excessive at household level Hebei province so as to provide a basis for prevention control deficiency disorders(IDD). Methods According national project IDD surveillance,the county was taken elementary sampling unit. The towns villages were selected by systematic random every households chosen collect their edible 2008. content non-and regions detected direct titrition method...
Objective To investigate the iodine nutrition status of target population living in areas with low coverage rate iodized salt and to provide a basis prevent control deficiency. Methods The investigation was carried out lower than 80%, including 7 counties (city, district). Three townships(sub-district office) were sampled each county two elementary schools township(sub-district office). Urinary level measured for 40 children aged from 8 10 years old school. Drinking water collected...
Rationale Approximately 1.2 million Americans have been infectedwith human immunodeficiency virus (HIV‐1). Among the HIV‐1‐associated spectrumof cardiovascular disorders, pulmonary hypertension (PH) causes high morbidityand mortality. The mechanismsunderlying this increased susceptibility of HIV patients to develop PH yetto be defined. We previously demonstrated that 5‐lipoxygenase (ALOX5) is apotential mediator in HIV‐induced (HIV‐PH). microRNAs (miRNAs or miR), play a pivotal role as...