A5052925888- Diet and metabolism studies
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Metabolism and Genetic Disorders
- Adipose Tissue and Metabolism
- Medical Imaging Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Advanced X-ray and CT Imaging
- Intimate Partner and Family Violence
- Metabolism, Diabetes, and Cancer
- Muscle metabolism and nutrition
- Thyroid Cancer Diagnosis and Treatment
- Neurological and metabolic disorders
- Atrial Fibrillation Management and Outcomes
- Pancreatic function and diabetes
- Cardiac Structural Anomalies and Repair
- Coronary Interventions and Diagnostics
- Thyroid and Parathyroid Surgery
- Radiomics and Machine Learning in Medical Imaging
- Sexual Assault and Victimization Studies
- Diabetes and associated disorders
- Criminal Justice and Corrections Analysis
- Diabetes Management and Research
Aarhus University Hospital
2021-2025
Steno Diabetes Centers
2021-2024
Aarhus University
2023-2024
University of Southern Denmark
2019
Abstract Objective A ketogenic diet (KD) characterized by very low carbohydrate intake and high fat consumption may simultaneously induce weight loss be cardioprotective. The “thrifty substrate hypothesis” posits that ketone bodies are more energy efficient compared with other cardiac oxidative substrates such as fatty acids. This work aimed to study whether a KD presumed increased myocardial body utilization reduces acid uptake oxidation, resulting in decreased oxygen (MVO 2 ). Methods...
A ketogenic diet (KD) can induce weight loss and improve glycemic regulation, potentially reducing the risk of type 2 diabetes development. To elucidate underlying mechanisms behind these beneficial effects a KD, we investigated impact KD on organ-specific insulin sensitivity (IS) in skeletal muscle, liver, adipose tissue. We hypothesized that would increase IS muscle. The study included 11 individuals with obesity who underwent randomized, crossover trial two 3-week interventions: 1) 2)...
Abstract Aims Previous observational studies suggest that preoperative imaging in patients with chronic ischemic heart failure (iHF) may identify non-contractile, hypoperfused, yet metabolically viable (hibernating) myocardial segments can regain function after coronary revascularization. Various techniques, including positron emission tomography (PET) retention tracers like 82Rb, have shown equivocal results. However, recent randomized found limited value these methods for predicting...
Ketones are increasingly recognized as an important and possibly oxygen sparing source of energy in vital organs such the heart, brain kidneys. Drug treatments, dietary regimens oral ketone drinks designed to deliver ketones for organ tissue production have therefore gained popularity. However, whether ingested taken up by various extra-cerebral tissues what extent is still largely unexplored. It was aim this study use positron emission tomography (PET) explore whole body dosimetry,...
Abstract Aims We wanted to assess if 15O-H2O myocardial perfusion imaging (MPI) in a clinical setting can predict referral coronary artery catheterization [coronary angiography (CAG)], execution of percutaneous intervention (PCI), and post-PCI angina relief for patients with previous bypass graft (CABG). Methods results analysed 172 symptomatic CABG referred positron emission tomography (PET) MPI at Aarhus University Hospital Department Nuclear Medicine & PET Centre, which five did not...
Abstract Aims Myocardial perfusion imaging (MPI) using [15O]H2O positron emission tomography (PET) is used to guide the selection of patients with angina for invasive angiography and possible revascularization. Our study evaluated (i) whether atrial fibrillation (AF) reduces global hyperaemic myocardial blood flow (MBF) (ii) PET MPI effectively guides revascularization procedures ongoing AF. Methods results We prospectively recruited 346 persistent or paroxysmal AF referred...
The connection between peripheral insulin resistance (IR) and coronary artery disease is well-established. Both are major risk factors for the development of ischemic cardiomyopathy potentially leading to heart failure (HF). Whether cardiac IR also impacts overall survival morbidity still debated. We therefore aimed test if predicts mortality cardiovascular events (MACE) in patients with HF scheduled viability testing before revascularization.This retrospective study included 131 a clinical...
<p dir="ltr"><b>Abstract</b></p><p dir="ltr">A ketogenic diet (KD) can induce weight loss and improve glycemic regulation, potentially reducing the risk of developing type 2 diabetes. To elucidate underlying mechanisms behind these beneficial effects a KD, we investigated impact KD on organ-specific insulin sensitivity (IS) in skeletal muscle, liver, adipose tissue. We hypothesized that would increase IS muscle. The study included 11 individuals with obesity who...
<p dir="ltr"><b>Abstract</b></p><p dir="ltr">A ketogenic diet (KD) can induce weight loss and improve glycemic regulation, potentially reducing the risk of developing type 2 diabetes. To elucidate underlying mechanisms behind these beneficial effects a KD, we investigated impact KD on organ-specific insulin sensitivity (IS) in skeletal muscle, liver, adipose tissue. We hypothesized that would increase IS muscle. The study included 11 individuals with obesity who...
The aim of this study was to compare early (15 min) and late (60 [18F]FDOPA PET/CT acquisition times in the detection recurrence/residual disease medullary thyroid cancer (MTC) patients.Thirty-two dual-phase PET scans were retrospectively reviewed. Scan indications (1) suspected recurrence MTC, (2) treatment monitoring, or (3) restaging. In four scans, no final verification could be obtained, one scan excluded due non-consistency with protocol. Images analyzed visually semiquantitatively...
Abstract Background: Ketones are increasingly recognized as an important and possibly oxygen sparing source of energy in vital organs such the heart, brain kidneys. Drug treatments, dietary regimens oral ketone drinks designed to deliver ketones for organ tissue production have therefore gained popularity. However, whether ingested taken up by various extra-cerebral tissues what extent is still largely unexplored. It was aim this study use positron emission tomography (PET) explore whole...
Abstract Funding Acknowledgements Type of funding sources: None. Background Myocardial perfusion imaging (MPI) by 15O-H2O positron emission tomography (PET) has excellent diagnostic accuracy for detecting significant coronary stenoses and consequently revascularization in patients with angina no previous artery disease (CAD). However, arrhythmias such as atrial fibrillation (AF) are thought to reduce myocardial globally thresholds indicating ischemic CAD therefore likely lower AF. Purpose To...