A5018661546- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Salivary Gland Tumors Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Radiation Dose and Imaging
- Head and Neck Cancer Studies
- Cerebrovascular and Carotid Artery Diseases
- Prostate Cancer Treatment and Research
- MRI in cancer diagnosis
- Cancer Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Vitamin D Research Studies
- Urological Disorders and Treatments
- Vasculitis and related conditions
- Medical Imaging and Pathology Studies
- Diabetes Management and Education
- Abdominal Trauma and Injuries
- Sarcoidosis and Beryllium Toxicity Research
- Obesity, Physical Activity, Diet
- Urinary and Genital Oncology Studies
- Hematological disorders and diagnostics
- Chronic Kidney Disease and Diabetes
Aarhus University Hospital
2015-2025
European Association of Nuclear Medicine
2021
Aarhus University
2015
Hospital de Santa Cruz
2013
Centro Hospitalar de Lisboa Ocidental
2013
University of Toronto
2008-2013
Hospital de Egas Moniz
2013
Mount Sinai Hospital
2013
St. Michael's Hospital
2008-2010
International Data Group (Sweden)
1981
Cardiac sarcoidosis (CS) is a potentially fatal condition lacking single test with acceptable diagnostic accuracy. 18F-FDG PET/CT has emerged as promising imaging modality, but challenged by physiological myocardial glucose uptake. An alternative tracer, 68Ga-DOTANOC, binds to somatostatin receptors on inflammatory cells in sarcoid granulomas. We therefore aimed conduct proof-of-concept study using 68Ga-DOTANOC diagnose CS. In addition, we compared accuracy and inter-observer variability of...
Context: Vitamin D3 might benefit prostate cancer (PCa) patients because cells can locally synthesize the active hormone calcitriol. Objective: Our objective was to determine effects of oral vitamin on D metabolites and PCa proliferative activity in tissue. Design Setting: We conducted a double-blind randomized clinical trial at surgical oncology clinics Toronto, Canada. Patients: (Gleason 6 or 7) participated study. Of 66 subjects who were enrolled, 63 completed dosing protocol....
Abstract Background Dynamic whole-body (D-WB) FDG PET/CT is a recently developed technique that allows direct reconstruction of multiparametric images metabolic rate uptake (MR ) and “free” (DV ). Multiparametric have markedly different appearance than the conventional SUV obtained by static PET imaging, normal values MR DV in frequently used reference tissues organs are lacking. The aim this study was therefore to: (1) provide an overview range variation tissues; (2) analyse organ...
Abstract Background Routine prostate-specific membrane antigen (PSMA) positron emission tomography (PET) performed for primary staging or restaging of prostate cancer patients is usually done as a single static image acquisition 60 min after tracer administration. In this study, we employ dynamic whole-body (D-WB) PET imaging to compare the pharmacokinetics [ 68 Ga]Ga-PSMA-11 and 18 F]PSMA-1007 in various tissues lesions, assess whether Patlak parametric images are quantitative improve...
We describe 2 cases of Ga-PSMA PET/CT in prostate cancer patients. Both demonstrated symmetrical bilateral involvement mediastinal and hilar lymph nodes besides findings relation with prostatic disease. In both cases, endobronchial ultrasound-guided biopsy showed that the thoracic was caused by nonnecrotic granulomas compatible sarcoidosis. The increased uptake can be seen active sarcoidosis, images mimicking those well known from FDG PET/CT. Because these findings, granulomatous disease has...
Abstract Background This study examines the clinical feasibility and impact of implementing a fully automated whole-body PET protocol with data-driven respiratory gating in patients broad range oncological non-oncological pathologies 592 FDG PET/CT were prospectively included. 200 lesions torso selected for further analysis, ungated (UG), belt gated (BG) (DDG) images reconstructed. All reconstructed using same data without prolonged acquisition time images. Images quantitatively analysed...
Contemporary PET/CT scanners can use 70-min dynamic whole-body (D-WB) PET to generate more quantitative information about FDG uptake than just the SUV by generating parametric images of metabolic rate (MRFDG). The analysis requires late (50-70 min) D-WB tissue data combined with full (0-70 arterial input function (AIF). Our aim was assess whether a scaled population-based (sPBIF) obviates need for early acquisition and allows clinically feasible 20-min examination.A PBIF calculated based on...
Abstract Background Correct classification of estrogen receptor (ER) status is essential for prognosis and treatment planning in patients with breast cancer (BC). Therefore, it recommended to sample tumor tissue from an accessible metastasis. However, ER expression can show intra- intertumoral heterogeneity. 16α-[ 18 F]fluoroestradiol ([ F]FES) Positron Emission Tomography/Computed Tomography (PET/CT) allows noninvasive whole-body (WB) identification distribution usually performed as a...
Two, respectively, 72- and 76-year-old men with recently diagnosed high-risk prostate cancer were referred for primary staging Ga-prostate-specific membrane antigen (PSMA) PET/CT. In both patients, the PET scans revealed increased Ga-PSMA uptake in, 3 4 rib fractures, characteristically placed as "pearls on a string." These cases illustrate important pitfalls when reporting PSMA PET.
Introduction. Glomerular filtration rate (GFR) is considered the best index of kidney function. The Modification Diet in Renal Disease (MDRD)-Study equation has gained worldwide acceptance for estimating GFR from serum creatinine. Recently Chronic Kidney Epidemiology Collaboration (CKD-EPI) group developed a new that claims to be more accurate and could replace MDRD routine clinical use. Nuclear medicine methods are accepted as accurate, have become regular practice provided they easily...
Diagnostic tests that use ionizing radiation play a central role in cardiology and their has grown recent years, leading to increasing concerns about potential stochastic effects. The aims of this study were compare the dose three diagnostic tests: single photon emission computed tomography (SPECT), invasive coronary angiography (ICA) cardiac (cardiac CT) evolution over time, assess influence body mass index on dose. We assessed consecutive patients included prospective registries (SPECT,...
We describe a case of 73-year-old man with newly diagnosed prostate cancer referred to Ga-PSMA PET/CT for staging. A focal uptake PSMA was visualized in the compatible primary cancer. Outside prostate, PSMA-avid paravertebral soft tissue mass observed. Further investigation MRI same region showed signs schwannoma. This shows importance including schwannoma differential diagnostic evaluation patients Ga-PSMA-positive foci locations, as schwannomas may show avid and potentially lead an...
Accurate diagnosis of axillary lymph node (ALN) metastases is essential for prognosis and treatment planning in breast cancer. Evaluation ALN done by ultrasound, which limited inter-operator variability, sentinel biopsy and/or dissection, none are without risks long-term complications. It known that conventional 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) has sensitivity metastases. However, a recently developed dynamic whole-body...
Background The number of unexpected focal [18F]FDG-avid findings (incidentalomas) within the parotid gland (PGI) continues to increase with expanding use PET/CT scanning. prevalence malignancy in PGIs is uncertain and appropriate management unsettled.
<h3>Background:</h3> Accurate and timely diagnosis is crucial in patients with suspected giant cell arteritis (GCA) as prompt treatment high-dose glucocorticoids may prevent severe ischemic complications, such sight loss. However, the use of without verified GCA should also be done caution due to potential side effects. Currently, multiple diagnostic imaging required establish an accurate diagnosis. In addition ultrasonography, 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed...
We describe 2 cases of skeletal “superscan” with 18F-choline PET/CT in prostate cancer (PCa) patients. Both demonstrated diffuse involvement besides their primary tumor. The first impression was that this presentation would be related to tumoral invasion by PCa as often seen 99mTc-MDP bone scintigraphy. In both cases, the shown caused hematological disease (polycythemia vera and chronic myelomonocytic leukemia), demonstrating importance also considering presence myeloproliferative syndromes...
Background: Total body and long-axial field-of-view (LAFOV) PET/CT represent visionary innovations in imaging enabling either improved image quality, reduction injected activity–dose or decreased acquisition time. An quality may affect visual scoring systems, including the Deauville score (DS), which is used for clinical assessment of patients with lymphoma. The DS compares SUVmax residual lymphomas liver parenchyma, here we investigate impact reduced noise on scanned a LAFOV PET/CT....
Until recently, quantitation of the net influx 2-[18F]fluorodeoxyglucose (FDG) to brain (Ki) and cerebrometabolic rate for glucose (CMRglc) required serial arterial blood sampling in conjunction with dynamic positron emission tomography (PET) recordings. Recent technical innovations enable identification an image-derived input function (IDIF) from vascular structures, but are frequently still encumbered by need interrupted sequences or prolonged recordings that seldom available outside a...