A5086329759- Pluripotent Stem Cells Research
- Cellular Mechanics and Interactions
- Electrospun Nanofibers in Biomedical Applications
- Genomics and Chromatin Dynamics
- Peripheral Artery Disease Management
- Birth, Development, and Health
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Angiogenesis and VEGF in Cancer
- RNA Interference and Gene Delivery
- Developmental Biology and Gene Regulation
- Single-cell and spatial transcriptomics
- Protein Degradation and Inhibitors
- Advanced biosensing and bioanalysis techniques
- Cancer Cells and Metastasis
- Hydrogels: synthesis, properties, applications
- Cell Adhesion Molecules Research
- Graphene and Nanomaterials Applications
Northwestern University
2019-2024
Universidad Autónoma de Nuevo León
2015
Centro de Investigación y Desarrollo
2015
Abstract Stem cell–based therapies can potentially regenerate many types of tissues and organs, thereby providing solutions to a variety diseases injuries. However, acute cell death, uncontrolled differentiation, low functional engraftment yields remain critical obstacles for clinical translation. Advanced biomaterial scaffolds that deliver stem cells the targeted tissues/organs promote survival, integration host may transform outcome regenerative therapies. In this review, authors briefly...
Diabetes is a known risk factor for various cardiovascular complications, mediated by endothelial dysfunction. Despite the high prevalence of this metabolic disorder, there lack in vitro models that recapitulate complexity genetic and environmental factors associated with diabetic Here, we utilized human induced pluripotent stem cell (iPSC)-derived cells (ECs) to develop We found phenotype was recapitulated patient-derived iPSC-ECs, even absence diabetogenic environment. Subsequent exposure...
Cellular adhesion enables communication between cells and their environment. Adhesion can be achieved throughout focal adhesions its components influence osteoblast differentiation of human mesenchymal stem (hMSCs). Because cell are closely related, this article aimed to analyze the expression profiles adhesion-related proteins during osteoblastic two hMSCs subpopulations (CD105(+) CD105(-)) propose a strategy for assembling bone grafts based on ability. In vitro experiments osteogenic in...
Introduction: Critical limb ischemia (CLI) causes severe morbidity and mortality with limited treatment options. Cell-based therapy has potential to advance outcomes but faces challenges in cell survival engraftment during delivery. We hypothesize that an antioxidant niche promotes adhesion spreading will improve rate, the goal of salvage through improved perfusion. Methods: Thermoresponsive poly(polyethylene glycol citrate-co-N-isopropylacrylamide) (PPCN) was synthesized conjugated...
Abstract Critical limb ischemia (CLI) presents a significant clinical challenge, leading to tissue and potentially resulting in necrosis or amputation. Cell‐based regenerative therapies offer promise for improving outcomes CLI, but their effectiveness is often limited by poor cell survival engraftment. This study hypothesized that thermo‐responsive polymer, poly(polyethylene glycol citrate‐co‐N‐isopropylacrylamide) (PPCN), combined with pro‐survival bioactive peptides, can create protective...
Abstract Efficient manipulation of cell fate is important for regenerative engineering applications. Lineage-specific differentiation stem cells particularly challenging due to their inherent plasticity. Engineered topographies may alter cellular plasticity through contact guidance. However, the ability rationally design regulate phenotypic outcomes has been hindered in part by lack tools quantify nanoscale chromatin structure reorganization live cells. Herein we use micropillars, molecular,...
Using chromatin packing macromolecular crowding (CPMC) model predictions and nanoscale imaging sequencing studies, we demonstrate that micropillar structures enhance osteogenic differentiation by decreasing scaling in hMSCs consequently increasing lineage-specific responsiveness.